{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:03:18Z","timestamp":1780045398702,"version":"3.53.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rituximab is a well\u2010established treatment for adult immune thrombocytopenia (ITP), with ~60% initial response (IR) and 20%\u201330% long\u2010term remissions. We conducted a register\u2010based cohort study of 759 ITP patients in Sweden, Denmark, and Norway treated with rituximab (2009\u20132018) to identify factors associated with response. IR\u2014platelet count \u2265\u200930\u2009\u00d7\u200910\u2079\/L or \u22652\u2010fold increase from baseline without bleeding and platelet\u2010elevating therapy in the prior 8 weeks, assessed 3\u20136 months post\u2010treatment\u2014occurred in 66.3%. IR in non\u2010pretreated patients (receiving rituximab as first\u2010line therapy) was 65% and 67% in pretreated (second\u2010line or later) patients. Response incidence rates were 1.67 (95% CI 1.32\u20132.08) and 1.77 (95% CI 1.60\u20131.95) per person\u2010years, respectively. Median response duration was 5.4 years (interquartile range [IQR] 2.6; 7.4), and 1.9 (IQR 0.4; 5.4), respectively. Sustained response (SR)\u2014platelet \u2265\u200930\u2009\u00d7\u200910\u2079\/L without bleeding and platelet\u2010elevating therapy after IR\u2014was 53.3% at 2 years and 31.4% at 5 years. Across evaluated covariates, no clear associations with IR were observed, indicating similar short\u2010term effectiveness across patient subgroups. Exploratory models identified inconsistent associations with comorbidity burden and corticosteroid co\u2010administration in some strata. Achieving complete response (platelet \u2265\u2009100\u2009\u00d7\u200910\u2079\/L and absence of bleeding) at 6 months was the strongest predictor of SR at 2 years (risk ratio [RR] 3.87, 95% CI 2.95\u20135.12) and 5 years (RR 4.30; 95% CI 2.95\u20136.27). Of 83 patients re\u2010treated after first relapse, 60% responded; among 19 re\u2010treated after second relapse, 63% responded. Our findings confirm rituximab response rates in ITP and highlight complete IR as the strongest predictor of long\u2010term outcomes.<\/jats:p>","DOI":"10.1002\/hem3.70373","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:28:51Z","timestamp":1777379331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors associated with response to rituximab in patients with immune thrombocytopenia"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2656-2836","authenticated-orcid":false,"given":"Galina","family":"Tsykunova","sequence":"first","affiliation":[{"name":"Department of Hemato\u2010Oncology \u00d8stfold Hospital Gr\u00e5lum Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Hematology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eskild Bendix","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor Henrik Anderson","family":"Tvedt","sequence":"additional","affiliation":[{"name":"Department of Hematology Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department and Research Unit of Hematology Odense University Hospital and University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Fynbo","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Centre for Pharmacoepidemiology, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Bahmanyar","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Centre for Pharmacoepidemiology, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Ghanima","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology \u00d8stfold Hospital Gr\u00e5lum Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1810479"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-1-200701020-00006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00003-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-393975"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23518"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61495-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-582346"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25632"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024013067"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.952"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.103291"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24434"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12839"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-751719"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.07.015"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"},{"issue":"3","key":"e_1_2_10_21_1","first-page":"159","article-title":"Effects of glucocorticoids on B\u2010cell subpopulations in patients with IgG4\u2010related disease","volume":"37","author":"Lanzillotta M","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4616"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01100.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108541"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-02893-y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13827"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.02.009"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23130"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04889.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21512"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01486.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02686.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-1992-4"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-229815"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-374777"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-455691"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hem3.70373","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:08:04Z","timestamp":1780042084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.70373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/hem3.70373"],"URL":"https:\/\/doi.org\/10.1002\/hem3.70373","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70373"}}