{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:03:20Z","timestamp":1780045400645,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent clinical trials have underscored the value of repeated minimal residual disease (MRD) measurements as a highly sensitive method for detecting subclinical disease and enabling dynamic risk stratification in hematologic malignancies. Despite its clinical potential, the complex and heterogeneous nature of MRD kinetics presents significant challenges for interpreting and integrating it into routine clinical decision\u2010making. In this study, we present a comprehensive, model\u2010based workflow for the longitudinal analysis of MRD trajectories designed to improve relapse risk prediction. We applied this newly developed workflow to a cohort of patients with mantle cell lymphoma (MCL). MRD measurements were collected from both bone marrow (BM) and peripheral blood (PB) over time, stored in the Fondazione Italiana Linfomi MCL0208 clinical trial. Using our functional MRD workflow, we defined four MRD dynamics that collapsed into two clinically relevant groups: favorable (rapid, sustained negativization) and unfavorable (persistent or fluctuating MRD). Patients with unfavorable profiles showed significantly shorter time to progression (TTP), with hazard ratio (HR)\u2009=\u20094.18 (95% CI: 2.44\u20137.14) in BM and HR\u2009=\u20095.71 (95% CI: 2.86\u201311.42) in PB. External validation in the European MCL Network \u201cYounger trial\u201d confirmed the predictive power of this stratification, with Kaplan\u2013Meier analyses demonstrating significant prognostic discrimination. The most informative temporal windows for patient clustering vary by tissue. Early\u2010phase BM assessments offer greater discriminatory power, whereas late\u2010phase assessments are most informative in PB. These findings indicate that longitudinal MRD assessment in PB represents a clinically actionable strategy that could reduce dependence on invasive BM procedures.<\/jats:p>","DOI":"10.1002\/hem3.70375","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:39:52Z","timestamp":1777538392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dissecting minimal residual disease dynamics to improve outcome prediction in mantle cell lymphoma: Data from the Fondazione Italiana Linfomi (FIL)\u2010MCL0208 clinical trial"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3143-3330","authenticated-orcid":false,"given":"Francesca","family":"Cordero","sequence":"first","affiliation":[{"name":"Department of Computer Science University of Turin Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Hematology Division, Department of Molecular Biotechnologies and Health Sciences University of Turin Torino Italy"},{"name":"Hematology Unit Azienda Ospedaliero\u2010Universitaria \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Pernice","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Turin Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Genuardi","sequence":"additional","affiliation":[{"name":"Hematology Division, Department of Molecular Biotechnologies and Health Sciences University of Turin Torino Italy"},{"name":"Hematology Unit Azienda Ospedaliero\u2010Universitaria \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Volpatto","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Turin Torino Italy"},{"name":"Department of Mathematics \u201cG. Peano\u201d University of Turin Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Sirovich","sequence":"additional","affiliation":[{"name":"Department of Mathematics \u201cG. Peano\u201d University of Turin Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora Maria","family":"Civita","sequence":"additional","affiliation":[{"name":"Hematology Division, Department of Molecular Biotechnologies and Health Sciences University of Turin Torino Italy"},{"name":"Hematology Unit Azienda Ospedaliero\u2010Universitaria \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epidemiology Azienda Ospedaliera Universitaria Citt\u00e0 della Salute e della Scienza and CPO Piemonte Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-5755","authenticated-orcid":false,"given":"Simone","family":"Ragaini","sequence":"additional","affiliation":[{"name":"Hematology Division, Department of Molecular Biotechnologies and Health Sciences University of Turin Torino Italy"},{"name":"Hematology Unit Azienda Ospedaliero\u2010Universitaria \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Di Rocco","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Re","sequence":"additional","affiliation":[{"name":"Department of Haematology ASST\u2010Spedali Civili Hospital Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Stefoni","sequence":"additional","affiliation":[{"name":"Institute of Haematology L. e A. Ser\u00e0gnoli University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2047-1099","authenticated-orcid":false,"given":"Federica","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnologies and Health Sciences Universitaria Citt\u00e0 della Salute e della Scienza di Torino and Centre for Cancer Prevention Piemonte Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Boccomini","sequence":"additional","affiliation":[{"name":"SC Ematologia AOU \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Balzarotti","sequence":"additional","affiliation":[{"name":"Hematology Unit IRCCS Humanitas Research Hospital, Rozzano Milan 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