{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:08:17Z","timestamp":1787875697321,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Primary cutaneous follicle center lymphomas (PCFCLs) are indolent B\u2010cell neoplasms limited to the skin and effectively managed with local therapies. Distinguishing PCFCL from systemic follicular lymphoma (sFL) with cutaneous involvement (FL_CI) is challenging due to overlapping features. We performed an integrated pathological and genetic analysis of skin samples of 24 PCFCL and 10 FL_CI, which showed subtle pathological changes (decreased BCL2 and CD10, increased CD23 expression in PCFCL), but markedly distinct mutational landscapes. FL_CI exhibited recurrent mutations in chromatin\u2010modifying genes (\n                    <jats:italic>CREBBP<\/jats:italic>\n                    90%,\n                    <jats:italic>KMT2D<\/jats:italic>\n                    90%, and\n                    <jats:italic>EP300<\/jats:italic>\n                    30%), closely resembling sFL. In contrast, PCFCL displayed a more heterogeneous profile, with mutations affecting B\u2010cell development, cell adhesion, and immune evasion. These molecular alterations identified three distinct PCFCL subgroups. Group 1 (44%) harbored mutations in immune evasion genes (\n                    <jats:italic>IRF8<\/jats:italic>\n                    ,\n                    <jats:italic>FAS<\/jats:italic>\n                    ,\n                    <jats:italic>CIITA<\/jats:italic>\n                    , and\n                    <jats:italic>B2M<\/jats:italic>\n                    ) and was associated with CD10 negativity, diffuse architecture, and localization in non\u2010photoexposed areas. Group 2 (20%) showed activating\n                    <jats:italic>STAT6<\/jats:italic>\n                    and\n                    <jats:italic>CREBBP<\/jats:italic>\n                    mutations, consistent CD23 and CD10 positivity, and exclusive presentation in sun\u2010exposed sites. Group 3 (20%) shared a similar clinicopathological profile to Group 2 but was defined by\n                    <jats:italic>TNFRSF14<\/jats:italic>\n                    mutations. Clonal origin and mutational evolution were studied in five patients, one with synchronous PCFCL and four with sequential samples from two PCFCL and 2 FL_CI. This analysis supports a model of PCFCL oncogenesis driven by circulating progenitors following complex evolutionary patterns, including convergent evolution and greater clonal diversity at relapse. Overall, our study refines the mechanisms driving PCFCL pathogenesis, while providing a framework for PCFCL differential diagnosis and clinical management.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70382","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:56:57Z","timestamp":1780041417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genomic heterogeneity in primary cutaneous follicular center lymphomas reveals different clinicopathological subgroups"],"prefix":"10.1002","volume":"10","author":[{"given":"Andrea","family":"Combalia","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Cli\u0301nic de Barcelona Barcelona Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Vidal\u2010Robau","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona Barcelona Spain"},{"name":"Department of Pathology, Haematopathology Section Hospital Cli\u0301nic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Nadeu","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona Barcelona Spain"},{"name":"Department of Pathology, Haematopathology Section Hospital Cli\u0301nic de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Frigola","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona Barcelona Spain"},{"name":"Department of Pathology, Haematopathology Section Hospital Cli\u0301nic de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lopez\u2010Oreja","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haematopathology Section Hospital Cli\u0301nic de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Garcia","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melika","family":"Bashiri","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-4971","authenticated-orcid":false,"given":"Pablo","family":"Mozas","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"},{"name":"Department of Hematology Hospital Cli\u0301nic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Lopez\u2010Guillermo","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"},{"name":"Department of Hematology Hospital Cli\u0301nic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Salaverria","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Estrach","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Cli\u0301nic de Barcelona Barcelona Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona Barcelona Spain"},{"name":"Department of Pathology, Haematopathology Section Hospital Cli\u0301nic de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Garcia\u2010Herrera","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona Barcelona Spain"},{"name":"Department of Pathology, Haematopathology Section Hospital Cli\u0301nic de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Albero","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"issue":"16","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood-2018-11-881268","article-title":"The 2018 update of the WHO\u2010EORTC classification for primary cutaneous lymphomas","volume":"133","author":"Willemze R","year":"2019","journal-title":"Blood"},{"issue":"6","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jaad.2014.01.862","article-title":"Chromosomal anomalies in primary cutaneous follicle center cell lymphoma do not portend a poor prognosis","volume":"70","author":"Abdul\u2010Wahab 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Dermatol"},{"issue":"4","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/his.13279","article-title":"Diagnostic value of STMN1, LMO2, HGAL, AID expression and 1p36 chromosomal abnormalities in primary cutaneous B cell lymphomas","volume":"71","author":"Verdanet E","year":"2017","journal-title":"Histopathology"},{"issue":"3","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1182\/bloodadvances.2020002469","article-title":"Genomic landscape of cutaneous follicular lymphomas reveals 2 subgroups with clinically predictive molecular features","volume":"5","author":"Zhou XA","year":"2021","journal-title":"Blood Adv"},{"issue":"21","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14215274","article-title":"Panel sequencing of primary cutaneous B\u2010cell lymphoma","volume":"14","author":"Wobser 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