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We conducted a multicenter retrospective study to evaluate the safety and efficacy of var\u2010cel in patients with relapsed or refractory (R\/R) mantle cell lymphoma (MCL) treated at four Spanish centers, including patients enrolled in the CART19\u2010BE\u201001 trial and a subsequent compassionate use program. Thirty patients underwent leukapheresis; 27 received var\u2010cel following lymphodepletion and fractionated infusion in three escalating doses (0.1 to 5 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    CAR T cells\/kg). Any\u2010grade cytokine release syndrome (CRS) and immune effector cell\u2010associated neurotoxicity syndrome (ICANS) occurred in 93% and 4%, respectively, with Grade \u22653 CRS and\/or ICANS observed in a single patient (4%). The overall response rate among infused patients was 89% (95% CI, 71\u201398), including 78% complete responses (95% CI, 58\u201391). Median duration of response and progression\u2010free survival were 17.1 and 15.4 months, respectively. With a median follow\u2010up of 21.7 months, median overall survival was 35.2 months. In this multicenter academic experience, var\u2010cel demonstrated high antitumor activity with low rates of severe CRS and ICANS, supporting its use within a coordinated national network.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70388","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:40:08Z","timestamp":1779378008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Varnimcabtagene autoleucel (ARI\u20100001) in relapsed or refractory mantle cell lymphoma"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2942-1362","authenticated-orcid":false,"given":"Nil","family":"Albiol","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona Barcelona Spain"},{"name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2010 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer 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