{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:27:36Z","timestamp":1793795256580,"version":"4.6.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["21267"],"award-info":[{"award-number":["21267"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00970"],"award-info":[{"award-number":["PI20\/00970"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Myelodysplastic syndromes (MDS) are clinically and biologically diverse disorders, emphasizing the need for personalized treatment approaches. The International Working Group for Prognostication of MDS (IWG_PM) recently introduced a molecular classification, referred to as the MDS taxonomy, that categorizes patients into 16 subgroups based on 21 gene mutations, 6 cytogenetic abnormalities, and loss of heterozygosity (LOH) at\n                    <jats:italic>TP53<\/jats:italic>\n                    and\n                    <jats:italic>TET2<\/jats:italic>\n                    loci. This study sought to validate and enhance the clinical relevance of the MDS taxonomy by analyzing a large retrospective cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095136) and transcriptomic data from a prospective cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009477). The taxonomy successfully identified subgroups with distinct clinical characteristics and disease progression patterns. However, incorporating gene interactions from taxonomy subgroups did not improve the prognostic performance of the Molecular International Prognostic Scoring System (IPSS\u2010M). We further assessed whether the taxonomy could guide management in patients receiving disease\u2010modifying therapies. Except for the \u201c\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010complex\u201d subgroup, taxonomy classifications were not predictive of hypomethylating agent response or transplant outcomes. Nonetheless, they correlated with overall survival, suggesting that while both IPSS\u2010M and the taxonomy capture disease biology, other non\u2010genetic factors may influence treatment response. RNA sequencing confirmed the biological distinctiveness of the taxonomy groups. Transcriptomic profiling of CD34+ bone marrow cells revealed unique, homogeneous gene expression patterns, particularly within the AML\u2010like, bi\n                    <jats:italic>TET2<\/jats:italic>\n                    ,\n                    <jats:italic>SF3B1<\/jats:italic>\n                    , and\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010complex subgroups. Further integration of multi\u2010omics data may refine MDS classification, improving clinical decision\u2010making and guiding the development of targeted therapies.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70406","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:14:13Z","timestamp":1782137653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world, multi\u2010omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS)"],"prefix":"10.1002","volume":"10","author":[{"given":"Giulia","family":"Maggioni","sequence":"first","affiliation":[{"name":"IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Todisco","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital  Rozzano Milan Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Sauta","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Lanino","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Yale School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somedeb","family":"Ball","sequence":"additional","affiliation":[{"name":"Vanderbilt Ingram Cancer Center and Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P.","family":"Bewersdorf","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Yale School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Kewan","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine Yale School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najla H.","family":"Al Ali","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fenaux","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint\u2010Louis Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Santini","sequence":"additional","affiliation":[{"name":"University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoer","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology H. 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