{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:52:32Z","timestamp":1791204752153,"version":"4.2.0"},"reference-count":124,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal hematopoiesis and MM biology. We first discuss the physiological functions of TFs in lymphoid lineage commitment and terminal B\u2010cell differentiation into plasma cells. This provides insights into the contribution of key TFs, such as IRF4 and PRDM1, to development of MM. We then examine the regulatory mechanisms of TFs in MM, exploring how their deregulation participates in the pathogenesis of the disease. We summarize the roles of major TF families, highlighting both well\u2010established TFs essential for MM pathogenesis and emerging TFs with potential clinical relevance. In addition to their functional roles, several TFs show promise as biomarkers for patient stratification and risk assessment. Finally, we discuss recent advances that challenge the notion of TFs as \u201cundruggable\u201d, including siRNA\u2010loaded lipid nanoparticles or Proteolysis\u2010Targeting Chimeras (PROTACs), which offer novel opportunities to therapeutically modulate TF activity. These strategies could enable the development of novel interventions aimed at improving clinical outcomes and quality of life for MM patients. Collectively, this review integrates physiological and pathological insights into TF function in MM and underscores their potential as biomarkers and actionable targets in precision medicine.<\/jats:p>","DOI":"10.1002\/hem3.70411","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:31:03Z","timestamp":1782923463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple myeloma: A tale of deregulated transcription factors"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9924-0965","authenticated-orcid":false,"given":"Nahia","family":"G\u00f3mez\u2010Echarte","sequence":"first","affiliation":[{"name":"Centre for Applied Medical Research (CIMA), Navarra Medical Research Institute (idiSNA) Pamplona Spain"},{"name":"Cancer Centre Cl\u00ednica Universidad de Navarra (CCUN) Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5786-5273","authenticated-orcid":false,"given":"Edurne","family":"San Jos\u00e9\u2010En\u00e9riz","sequence":"additional","affiliation":[{"name":"Centre for Applied Medical Research (CIMA), Navarra Medical Research Institute (idiSNA) Pamplona Spain"},{"name":"Cancer Centre Cl\u00ednica Universidad de Navarra (CCUN) Pamplona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1656-9355","authenticated-orcid":false,"given":"Est\u00edbaliz","family":"Urizar\u2010Compains","sequence":"additional","affiliation":[{"name":"Centre for Applied Medical Research (CIMA), Navarra Medical Research Institute (idiSNA) Pamplona Spain"},{"name":"Cancer Centre Cl\u00ednica Universidad de Navarra (CCUN) Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-7785","authenticated-orcid":false,"given":"Paula","family":"Rodriguez\u2010Otero","sequence":"additional","affiliation":[{"name":"Cancer Centre Cl\u00ednica Universidad de Navarra (CCUN) Pamplona Spain"},{"name":"Servicio de Hematolog\u00eda y Terapia Celular, Cl\u00ednica Universidad de Navarra (CUN) Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-8790","authenticated-orcid":false,"given":"Felipe","family":"Pr\u00f3sper","sequence":"additional","affiliation":[{"name":"Centre for Applied Medical Research (CIMA), Navarra Medical Research Institute (idiSNA) Pamplona Spain"},{"name":"Cancer Centre Cl\u00ednica Universidad de Navarra (CCUN) Pamplona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer Madrid Spain"},{"name":"Servicio de Hematolog\u00eda y Terapia Celular, Cl\u00ednica Universidad de Navarra (CUN) Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-9560","authenticated-orcid":false,"given":"Xabier","family":"Agirre","sequence":"additional","affiliation":[{"name":"Centre for Applied Medical Research (CIMA), Navarra Medical Research Institute (idiSNA) Pamplona Spain"},{"name":"Cancer Centre Cl\u00ednica Universidad de Navarra (CCUN) Pamplona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.122"},{"issue":"1","key":"e_1_2_7_3_1","article-title":"Epidemiology, staging, and management of multiple myeloma","volume":"9","author":"Padala SA","year":"2021","journal-title":"Med Sci (Basel, Switzerland)"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520312"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27422"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0173-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1364"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-24-0256"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01078-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07064"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-371567"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-030220-015007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06112-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3167"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.036"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-9069-0_3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202000034"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3519"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.02.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.001232"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12749"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-022-00968-0"},{"issue":"4","key":"e_1_2_7_24_1","first-page":"215","article-title":"Germinal center B cell dynamics","volume":"27","author":"Hyun S","year":"2015","journal-title":"Immunity"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2217"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.02.003"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1626"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.01.014"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802550106"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1555"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1339"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.3.1719"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1612"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7898"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5312.596"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(04)00019-4"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.276042.121"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.12.4457.412k48_4457_4463"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2001.tb01142.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0921-y"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2014.13"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2018.07.025"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2023.1611375"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014391"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-019-0154-2"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.09.078"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fonc.2018.00566","article-title":"The epigenome in multiple myeloma: impact on tumor cell plasticity and drug response","volume":"8","author":"De Smedt E","year":"2018","journal-title":"Front Oncol"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.09.007"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.191262"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025029422"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-808063"},{"key":"e_1_2_7_52_1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3324\/haematol.2024.285966","article-title":"BET inhibitors down\u2010regulate the expression of the essential lncRNA SMILO in multiple myeloma through regulation of the transcription factor FLI1","volume":"110","author":"G\u00f3mez\u2010Echarte N","year":"2025","journal-title":"Haematologica"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.180240.114"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26450"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00638-w"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01263-9"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.124"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016892"},{"key":"e_1_2_7_59_1","first-page":"1","article-title":"Knockdown of long non\u2010coding RNA H19 inhibits multiple myeloma cell growth via NF\u2010\u03baB pathway","volume":"7","author":"Sun Y","year":"2017","journal-title":"Sci Rep"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0543-4"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0036-x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2025.101177"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.01.007"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.53"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01078-0"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.4161\/21624011.2014.941742"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.66"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4603"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10258"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001002"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.265520.120"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00550-x"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-278788"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2460"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009772"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4602-4"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-706077"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-210526"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030215"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.358"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01271-9"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-022-00905-1"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217727"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-23-0062"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2022.104594"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-172866"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2016.07.006"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4670"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-2985"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2023.107343"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08070.x"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02377.x"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0060-0"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.334"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-23-0061"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0403-2"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-613968"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-023-01960-8"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-17-0606"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05408-1"},{"key":"e_1_2_7_101_1","article-title":"Multi\u2010omic and functional screening reveal targetable vulnerabilities in TP53 mutated multiple myeloma","author":"Tsallos D","year":"2024","journal-title":"medRxiv Prepr"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0666-5"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2815-7_9"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118209"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103015"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02425"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00691"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.12.017"},{"key":"e_1_2_7_109_1","article-title":"Anti\u2010CD38\u2010targeted piperazine\u2010derived lipid nanoparticles overcome hepatic clearance for mRNA delivery to multiple myeloma cells in vivo","author":"Figueroa\u2010espada CG","year":"2025","journal-title":"bioRxiv"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.05.026"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.017"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3016"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16979"},{"issue":"2016","key":"e_1_2_7_114_1","first-page":"1","article-title":"Bromodomain inhibition of the transcriptional coactivators CBP\/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma","volume":"5","author":"Conery AR","year":"2016","journal-title":"eLife"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00400-0"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007155"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-25-3440"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6116"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4245"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02805-1"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01069"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092677"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309639"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02619"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51197-w"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hem3.70411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:09:31Z","timestamp":1791202171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.70411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":124,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/hem3.70411"],"URL":"https:\/\/doi.org\/10.1002\/hem3.70411","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70411"}}