{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:55:06Z","timestamp":1791881706554,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Biological mechanisms underlying clinical heterogeneity in central nervous system lymphoma (CNSL) are largely unknown. While previous studies suggest the chemokine CLL19 as a crucial factor for the formation of CNSL in murine models, its role in human disease remains elusive. Here, we performed in\u2010depth genetic and transcriptomic profiling of 82 CNSL specimens and identified distinct genetic aberrations and tumor cell compositions in lymphomas with high CCL19 expression, both of which were associated with immunosuppressive and anti\u2010apoptotic signatures. CCL19 levels varied widely across CNSL patients. High CCL19 expression was significantly and independently associated with inferior progression\u2010free and overall survival. Spatial and single\u2010nucleus analyses as well as immunohistochemistry revealed pericytes within vessel\u2010rich areas as the predominant source of CCL19, accompanied by significant co\u2010localization of CCL19 with its primary receptor CCR7 that was enriched in plasmablast\u2010like malignant B cells, as well as dendritic cells, NK cells, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Collectively, our study identified pericyte\u2010derived CCL19 as a novel prognostic marker in CNSL that is associated with unfavorable genetic aberrations and modifications of the immune landscape towards a resting tumor microenvironment. Spatial CCR7 co\u2010localization suggests avenues for future therapeutic strategies targeting the CCL19\u2013CCR7 axis.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70412","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:17:44Z","timestamp":1782137864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spatial and multi\u2010omic profiling reveals pericyte\u2010derived CCL19 as a key prognostic factor in CNS lymphoma"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-6050","authenticated-orcid":false,"given":"Julia C.","family":"Kuehn","sequence":"first","affiliation":[{"name":"Department of Medicine I, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauritz","family":"Miarka","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Sankowski","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Freiburg and German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurik","family":"Mutter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Divisions of Oncology and Hematology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas N.","family":"Neidert","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site Freiburg and German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"Department of Neurosurgery, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Grabis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Klingler","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Hummel","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Bleul","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza M.","family":"Lauer","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter H.","family":"Heiland","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site Freiburg and German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"Department of Neurosurgery, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Department of Neurosurgery, University Hospital Erlangen Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg Erlangen Germany"},{"name":"Department of Neurological Surgery, Lou and Jean Malnati Brain Tumor Institute, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans C.","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation University Hospital Essen, University Duisburg\u2010Essen, West German Cancer Center, German Cancer Consortium (DKTK Partner Site Essen), Center for Molecular Biotechnology Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology University Hospital D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Illerhaus","sequence":"additional","affiliation":[{"name":"Clinic of Hematology, Oncology, Stem Cell Transplantation and Palliative Care, Klinikum Stuttgart Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"von Baumgarten","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Alig","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation University Hospital Essen, University Duisburg\u2010Essen, West German Cancer Center, German Cancer Consortium (DKTK Partner Site Essen), Center for Molecular Biotechnology Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Diehn","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University Medical Center Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian E. 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