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Allocation into risk groups is based on staging with positron emission tomography and computed tomography (PET\/CT) and the presence or absence of risk factors. Standard treatment for early\u2010stage favorable classic HL (cHL) consists of two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), followed by 20\u2009Gy involved\u2010site radiotherapy (IS\u2010RT). Two cycles of escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (eBEACOPP) or a procarbazine\u2010free eBEACOPP variant plus two cycles of ABVD, followed by 30\u2009Gy IS\u2010RT in the case of PET\/CT positivity and no further treatment in the case of PET\/CT negativity after chemotherapy should be considered in patients with early\u2010stage unfavorable cHL \u2264 60 years. If a less intensive approach is preferred and in individuals &gt; 60 years, four cycles of A(B)VD followed by 30\u2009Gy IS\u2010RT can be given. In advanced cHL, brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone (BrECADD) for four (in the case of PET\/CT negativity after two cycles) or six cycles (in the case of PET\/CT positivity after two cycles), followed by PET\/CT\u2010guided 30\u2009Gy IS\u2010RT should be considered in patients \u2264 60 years. Six cycles of nivolumab and AVD (N\u2010AVD) followed by PET\/CT\u2010guided 30\u2009Gy IS\u2010RT represents a less intensive alternative for younger patients and the preferred approach for patients &gt; 60 years. Patients with cHL recurrence should receive checkpoint inhibitor\u2010containing salvage treatment followed by high\u2010dose chemotherapy and autologous stem cell transplantation if eligible. Treatment of nodular lymphocyte\u2010predominant HL differs from cHL in some situations and may contain an anti\u2010CD20 antibody. This guideline aims at providing recommendations for diagnosis, staging, treatment, and follow\u2010up of HL.<\/jats:p>","DOI":"10.1002\/hem3.70422","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:40:39Z","timestamp":1782229239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hodgkin lymphoma: EHA Clinical Practice Guidelines for diagnosis, treatment, and follow\u2010up"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1927-3514","authenticated-orcid":false,"given":"Dennis A.","family":"Eichenauer","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, German Hodgkin Study Group University of Cologne Cologne 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