{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:52:46Z","timestamp":1791204766599,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Improved understanding of how chimeric antigen receptor (CAR) and endogenous T\u2010cell phenotypes associate with progression\u2010free survival (PFS) is needed to individualize and improve immunotherapy outcomes in multiple myeloma (MM). We characterized and investigated the prognostic value of immune dynamics defined with multidimensional and computational flow cytometry in 258 bone marrow aspirates from 107 MM patients treated with idecabtagene vicleucel in the KarMMa trial. At screening, there was an association between longer PFS and increased percentages of PD1\n                    <jats:sup>+<\/jats:sup>\n                    cytotoxic T cells and ICOS\n                    <jats:sup>\u2212<\/jats:sup>\n                    TIGIT\n                    <jats:sup>+<\/jats:sup>\n                    Tregs. At Month 1 after infusion, the presence of &gt;1% CAR\u2010T cells, a CD4\/CD8 CAR\u2010T\u2010cell ratio &gt;0.09, and greater abundance of non\u2010activated non\u2010cytolytic CAR\u2010T cells identified patients with longer PFS. Notably, 47 of the 115 endogenous T\u2010cell clusters were prognostic at the latest assessment performed after CAR\u2010T infusion. Lower percentages of ICOS\n                    <jats:sup>+<\/jats:sup>\n                    TIGIT\n                    <jats:sup>\u2212<\/jats:sup>\n                    Tregs showed the strongest association with longer PFS. Altogether, this large dataset of dynamic immune profiling throughout treatment with anti\u2010B\u2010cell maturation antigen (anti\u2010BCMA) CAR\u2010T cells uncovered that the T\u2010cell composition prior to apheresis as well as CAR\u2010T and endogenous T\u2010cell phenotypes after infusion associates with PFS. These findings have potential for translation into routine laboratory practice for improved understanding of response and resistance to CAR\u2010T cells in relapsed\/refractory MM.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70423","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:27:02Z","timestamp":1782995222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Idecabtagene vicleucel and endogenous T\u2010cell phenotypes linked to progression\u2010free survival in relapsed multiple myeloma"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-3815","authenticated-orcid":false,"given":"Bruno","family":"Paiva","sequence":"first","affiliation":[{"name":"Clinica Universidad de Navarra, CCUN, Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IDISNA) CIBER\u2010ONC Number CB16\/12\/00369 Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Manrique","sequence":"additional","affiliation":[{"name":"Clinica Universidad de Navarra, CCUN, Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IDISNA) CIBER\u2010ONC Number CB16\/12\/00369 Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Thompson","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy B.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Clinica Universidad de Navarra, CCUN, Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IDISNA) CIBER\u2010ONC Number CB16\/12\/00369 Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Martin","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-9595","authenticated-orcid":false,"suffix":"Jr.","given":"Larry D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Myeloma, Waldenstr\u00f6m's, and Amyloidosis Program, Simmons Comprehensive Cancer Center UT Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas G.","family":"Berdeja","sequence":"additional","affiliation":[{"name":"Greco\u2010Hainsworth Center for Research at Tennessee Oncology Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Lonial","sequence":"additional","affiliation":[{"name":"Emory School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noopur S.","family":"Raje","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Moreau","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas F.","family":"San\u2010Miguel","sequence":"additional","affiliation":[{"name":"Clinica Universidad de Navarra, CCUN, Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IDISNA) CIBER\u2010ONC Number CB16\/12\/00369 Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil C.","family":"Munshi","sequence":"additional","affiliation":[{"name":"The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana\u2010Farber Cancer Institute Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024850"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00933-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00222-X"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303379"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213614"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-23-0044"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27526"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00807-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02232"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.283888"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024965"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-3759"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02491-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21177-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01245-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo0514"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02496-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00763-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-22-0018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-025-02766-5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024015285"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005198"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-02129-y"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025250"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02292-1"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-025-01238-2"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02300-w"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025029773"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-00760"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04390-6"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.10.014"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025018078"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.70277"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60980-2"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35056"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.122"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hem3.70423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:09:35Z","timestamp":1791202175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.70423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/hem3.70423"],"URL":"https:\/\/doi.org\/10.1002\/hem3.70423","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70423"}}