{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:52:46Z","timestamp":1791204766574,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chimeric antigen receptor (CAR) T\u2010cell therapy has significantly improved outcomes in patients with relapsed\/refractory aggressive large B\u2010cell lymphoma (R\/R LBCL). Although thrombosis and bleeding complications have been increasingly reported, their clinical relevance and risk factors remain unclear, also due to heterogeneity between reporting studies. We investigated the incidence of thrombosis and bleeding in a more homogeneous real\u2010world multicenter cohort by analyzing 250 adults with R\/R LBCL who were included in the Dutch \u201cFollow that CAR!\u201d multicenter registry, and all received axicabtagene ciloleucel (axi\u2010cel) CAR T\u2010cell therapy. We assessed the impact of thrombosis and bleeding, incorporated as time\u2010dependent covariates on overall survival and explored associations with cytokine release syndrome (CRS), immune effector cell\u2010associated neurotoxicity syndrome (ICANS), anticoagulant therapy, and laboratory parameters. One\u2010year cumulative incidences of thrombosis and bleeding were 6.3% and 11.0%, respectively. Median time to thrombosis or bleeding was 28 days after infusion for both events. Bleeding was associated with poorer overall survival (hazard ratio [HR] 3.77, 95% CI 1.96\u20137.27). Patients with a CAR\u2010HEMATOTOX score\u2009\u22652 before CAR T\u2010cell therapy (HR 3.62, 95% CI 1.23\u201310.69), therapeutic anticoagulation at time of infusion (HR 3.74, 95% CI 1.33\u201310.49), or thrombocytopenia grade \u22653 (platelet count\u2009&lt;\u200950\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L) at time of infusion (HR 3.55, 95% CI 1.12\u201311.26, P\u2009=\u20090.03) had a significantly higher risk of bleeding. Our study confirms the high risk and clinical relevance of bleeding in patients receiving CAR T\u2010cell therapy. Prospective studies are necessary to confirm these results and to guide recommendations regarding modifiable risk factors such as the use of anticoagulation or transfusion thresholds during CAR T\u2010cell therapy.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70433","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:31:06Z","timestamp":1784032266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of thrombosis and bleeding following CAR T\u2010cell therapy: Insights from the Dutch \u201cFollow that CAR!\u201d registry"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0716-7844","authenticated-orcid":false,"given":"Amica K.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-8578","authenticated-orcid":false,"given":"Pim G. N. J.","family":"Mutsaers","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas M.","family":"van Kleij","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e1ria","family":"Vledder","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7674-2148","authenticated-orcid":false,"given":"Elise R. A.","family":"Pennings","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Spanjaart","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-1835","authenticated-orcid":false,"given":"Janneke W.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-0438","authenticated-orcid":false,"given":"Kylie","family":"Keijzer","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid M. P.","family":"Demandt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, GROW School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap A.","family":"van Doesum","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-674X","authenticated-orcid":false,"given":"Suzanne","family":"van Dorp","sequence":"additional","affiliation":[{"name":"Department of Hematology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-3566","authenticated-orcid":false,"given":"Margot","family":"Jak","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Kuipers","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-6950","authenticated-orcid":false,"given":"Tom","family":"van Meerten","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein W. 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