{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:14:51Z","timestamp":1791864891990,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Due to its high clinical and biological complexity, multiple myeloma (MM) is a malignancy of heterogeneous prognoses and outcomes. The International Myeloma Society (IMS)\/International Myeloma Working Group (IMWG) formulated a consensus genomic staging (CGS) of high\u2010risk MM (HRMM), aiming to refine and homogenize the classification of high\u2010risk disease. We evaluated the new HRMM criteria in a cohort of 1209 consecutive newly diagnosed MM patients with complete CGS data (except TP53 mutations), treated in a single center with contemporary regimens, including triplets and quadruplets, between 2010 and 2024. Based on CGS criteria, 25.2% of our cohort's patients were classified as HRMM. High\u2010risk status was associated with significantly inferior outcomes: median overall survival (OS) was 44 months for HRMM versus 93 months for standard\u2010risk (SR) patients (hazard ratio [HR] 1.81; P\u2009&lt;\u20090.001), corresponding to 5\u2010year OS rates of 40% versus 61%. Similarly, median progression\u2010free survival was 21.3 months for HRMM versus 36 months for SR (HR 1.64; P\u2009&lt;\u20090.001). The presence of \u22652 high\u2010risk features identified an ultra\u2010high\u2010risk group (4.4% of patients) with a threefold increased risk of death, compared to SR patients. CGS remained prognostic irrespective of renal dysfunction, stratifying patients with sCr\u2009&gt;\u20091.2\u2009mg\/dL (HR 1.71; P\u2009&lt;\u20090.001) and retained prognostic significance across different age groups, transplant eligibility, and treatment eras (pre\u2010 and post\u20102020). The IMS\/IMWG CGS effectively stratified patients in a large cohort treated at a tertiary academic center, identifying a substantially high\u2010risk population with poor outcomes despite modern therapies. This validation supports its deployment in clinical practice and research to enhance the precision of risk\u2010adapted management.<\/jats:p>","DOI":"10.1002\/hem3.70435","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:17:23Z","timestamp":1786025843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of the new IMS\/IMWG consensus genomic staging (CGS) of high\u2010risk multiple myeloma (HRMM) in a contemporary cohort of 1209 patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-5832","authenticated-orcid":false,"given":"Efstathios","family":"Kastritis","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gavriatopoulou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-0351","authenticated-orcid":false,"given":"Foteini","family":"Theodorakakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Solia","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Ntanasis\u2010Stathopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Malandrakis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kanellias","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Eleutherakis\u2010Papaiakovou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalini","family":"Migkou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Spiliopoulou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Katsadouros","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Vlachou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Fotiou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Giannakas","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erasmia","family":"Boutakoglou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavroula","family":"Giannouli","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, \u201cHippokration\u201d General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Tsirigotis","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine ATTIKON General University Hospital, Hematology Division, National and Kapodistrian University of Athens Athens 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