{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T20:18:41Z","timestamp":1788034721888,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    High\u2010dose chemotherapy (CT), followed by autologous hematopoietic cell transplantation (auto\u2010HCT) or consolidation CT, are postremission strategies for European LeukemiaNet 2022 (ELN2022) favorable\u2010 or intermediate\u2010risk patients with acute myeloid leukemia (AML) in complete remission (CR) without measurable residual disease (MRD). We conducted a retrospective, nonrandomized analysis to compare the efficacy and safety of auto\u2010HCT versus CT in newly diagnosed AML patients aged 18\u201365 years treated within two recent HOVON\u2013SAKK\u2013Nordic trials. From a total of 1005 patients with ELN2022 favorable\u2010 or intermediate\u2010risk AML, 224 received busulfan\/cyclophosphamide (Bu\/Cy), followed by auto\u2010HCT, and 199 received mitoxantrone\/etoposide\u2010based CT. The 5\u2010year relapse\u2010free survival (RFS) and overall survival (OS) were comparable between auto\u2010HCT and CT (RFS: 60% vs. 56%, P\u2009=\u20090.70; OS: 72% vs. 71%, P\u2009=\u20090.76). In multivariable analysis, auto\u2010HCT was not associated with a significant difference in RFS (HR 0.80, 95% CI 0.56\u20131.13, P\u2009=\u20090.20) or OS (HR 0.91, 95% CI 0.60\u20131.37, P\u2009=\u20090.64). Median time to platelet and neutrophil recovery was shorter with auto\u2010HCT than CT (platelet: 42 vs. 57 days, neutrophil: 13 vs. 39 days). Subgroup analysis revealed that patients achieving CR after the second induction cycle or with baseline white blood cell counts &gt;20\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L had longer RFS with auto\u2010HCT compared to CT (HR 0.17, P\u2009=\u20090.003 and HR 0.48, P\u2009=\u20090.02), which was not observed for OS. Focusing on ELN2022 favorable\u2010risk patients (excluding\n                    <jats:italic>NPM1<\/jats:italic>\n                    mut MRD\u2010positive) and MRD\u2010negative intermediate\u2010risk patients, RFS and OS were not different between consolidation strategies. Collectively, auto\u2010HCT yielded similar RFS and OS to mitoxantrone\/etoposide\u2010based CT in favorable\u2010 and intermediate\u2010risk AML, particularly in MRD\u2010negative patients, with faster hematologic recovery.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70462","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:48:57Z","timestamp":1787312937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autologous stem cell transplantation versus consolidation chemotherapy as postremission treatment in newly diagnosed favorable\u2010 and intermediate\u2010risk patients with AML: A comparative analysis of HOVON\u2013SAKK\u2013Nordic trials"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0047-3923","authenticated-orcid":false,"given":"Dimitrios","family":"Kotsos","sequence":"first","affiliation":[{"name":"Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin","family":"Hazenberg","sequence":"additional","affiliation":[{"name":"University Medical Center, University Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pabst","sequence":"additional","affiliation":[{"name":"University Hospital, Inselspital Bern Switzerland"},{"name":"Swiss Group for Clinical Cancer Research (SAKK) Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Gradowska","sequence":"additional","affiliation":[{"name":"Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"HOVON Foundation Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-7931","authenticated-orcid":false,"given":"Markus G.","family":"Manz","sequence":"additional","affiliation":[{"name":"Swiss Group for Clinical Cancer Research (SAKK) Bern Switzerland"},{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Maertens","sequence":"additional","affiliation":[{"name":"University Hospital Gasthuisberg Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Graux","sequence":"additional","affiliation":[{"name":"Mont\u2010Godinne University Hospital Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christiane","family":"Vekemans","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-9704","authenticated-orcid":false,"given":"Bjorn T.","family":"Gjertsen","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital, University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina H. M. J.","family":"Van Elssen","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J. M.","family":"Valk","sequence":"additional","affiliation":[{"name":"Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edo","family":"Vellenga","sequence":"additional","affiliation":[{"name":"University Medical Center, University Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Ossenkoppele","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Cancer Center Amsterdam University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"L\u00f6wenberg","sequence":"additional","affiliation":[{"name":"Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H. G. P.","family":"Raaijmakers","sequence":"additional","affiliation":[{"name":"Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerwin","family":"Huls","sequence":"additional","affiliation":[{"name":"University Medical Center, University Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurjen","family":"Versluis","sequence":"additional","affiliation":[{"name":"Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001982"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.1066"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.280027"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100873"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"148","article-title":"Optimal post\u2010remission consolidation therapy in patients with AML","volume":"147","author":"Jimenez\u2010Chillon C","year":"2023","journal-title":"Acta Haematol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10060179"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","unstructured":"VersluisJ CornelissenJJ CraddockC et al. 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