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We prospectively assessed the multidimensional recovery of lymphoma patients in remission, before leukapheresis, before CAR T\u2010cell infusion, and 3, 6, and 12 months thereafter. Validated tools were used to measure lymphoma\u2010related and global health\u2010related quality of life (HRQoL; Functional Assessment of Cancer Therapy\u2010Lymphoma [FACT\u2010Lym] and EQ\u20105D\u20105L), cognitive complaint (FACT\u2010Cognition), fatigue (FACIT\u2010Fatigue subscale), psychological status (Hospital Anxiety and Depression Scale, Post\u2010Traumatic Check List Scale), and sexuality (Relationship and Sexuality Scale). Beyond 12 months of remission, we also surveyed physical, professional, sexual, and general life status. At 3, 6, and 12 months, 53, 35, and 23 patients were evaluable, respectively. Improvement in lymphoma\u2010related HRQoL was clinically relevant at 3, 6, and 12 months with a mean change from baseline of 10.9 (95% confidence interval [CI]: 5.8; 16.1), 12.2 (95% CI: 4.2; 20.1), and 11.72 (95% CI: 2.06; 21.38), respectively. Improvement in global HRQoL, fatigue, and anxiety was clinically relevant, but 20%\u201340% of patients experienced persistent fatigue, psychological distress, and cognitive complaints over time. Beyond 12 months after CAR T cells, 81.8% of 22 evaluable patients were satisfied with their daily life. Physical activity, professional, sexual, and global well\u2010being had returned to prediagnosis levels in nearly half of the patients. We found an improvement in HRQoL after CAR T\u2010cell therapy including anxiety, depression, sexual satisfaction, and general well\u2010being. However, not all patients recover a \u201cnormal life.\u201d Further research is needed to determine which patients are at risk of quality\u2010of\u2010life impairment to improve recovery after CAR T\u2010cell infusion.<\/jats:p>","DOI":"10.1002\/hem3.72","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T11:11:50Z","timestamp":1716808310000},"source":"Crossref","is-referenced-by-count":9,"title":["Remission after CAR T\u2010cell therapy: Do lymphoma patients recover a normal life?"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2570-3637","authenticated-orcid":false,"given":"Alya","family":"Perthus","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie\u2014CHU Pontchaillou, Department of Hematology University Hospital of Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Colin","sequence":"additional","affiliation":[{"name":"Service 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