{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:52:43Z","timestamp":1790409163001,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI22\/00647"],"award-info":[{"award-number":["FIS PI22\/00647"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["ICI19\/00025"],"award-info":[{"award-number":["ICI19\/00025"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The 2\/20\/20 International Myeloma Working Group (IMWG) score is the most employed risk score in clinical practice to evaluate the risk of progression from smoldering multiple myeloma (SMM) to symptomatic multiple myeloma. However, it faces a serious limitation: The risk score is applied at diagnosis and cannot be reapplied. Since a dynamic accurate patient risk assessment for progression is necessary, we aimed to investigate whether the detection of an evolving pattern in serum M\u2010protein (SMP) improves the identification of high\u2010risk patients. Eighty\u2010three patients diagnosed with SMM between 2011 and 2020 were included. Patients were initially classified applying the 2\/20\/20 IMWG score at baseline and later reclassified depending on the presence of an SMP evolving pattern into six groups. We regrouped the patients into three final risk groups: low\u2010risk, intermediate\u2010risk, and high\u2010risk. The risk of progression at two years for the high\u2010risk group was 88% and all patients had progressed at 4 years. The performance measurements were superior for the new 2\/20\/20\u2010Evolving score independently for the detection of high\u2010risk patients. We show that the sequential measurement of the SMP is a noninvasive and widely available test that improves the 2\/20\/20 IMWG risk score.<\/jats:p>","DOI":"10.1002\/hem3.76","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T12:58:21Z","timestamp":1715000301000},"source":"Crossref","is-referenced-by-count":15,"title":["The evolving pattern of the monoclonal protein improves the IMWG 2\/20\/20 classification for patients with smoldering multiple myeloma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7568-2527","authenticated-orcid":false,"given":"Anna","family":"de Daniel","sequence":"first","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-0921","authenticated-orcid":false,"given":"Luis Gerardo","family":"Rodr\u00edguez\u2010Lobato","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tovar","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4036-754X","authenticated-orcid":false,"given":"M. Teresa","family":"Cibeira","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-5420","authenticated-orcid":false,"given":"Aina","family":"Oliver\u2010Cald\u00e9s","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Isola","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Lozano","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4563-3405","authenticated-orcid":false,"given":"Joan","family":"Blad\u00e9","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2534-9239","authenticated-orcid":false,"given":"Laura","family":"Rosi\u00f1ol","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4930-9255","authenticated-orcid":false,"given":"Carlos","family":"Fern\u00e1ndez de Larrea","sequence":"additional","affiliation":[{"name":"Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Cl\u00ednic of Barcelona Universitat de Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01916"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04654.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070389"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0077-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-088443"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0013-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.65"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.100784"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.124"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2020.103496"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X06295361"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02183-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300439"},{"key":"e_1_2_9_17_1","first-page":"1","article-title":"The role of early intervention in high\u2010risk smoldering myeloma","volume":"40","author":"Joseph NS","year":"2020","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00719-0"},{"key":"e_1_2_9_19_1","unstructured":"National Comprehensive Cancer Network.Multiple Myeloma (Version 3.2023). Accessed February 2 2024.http:\/\/www.nccn.org\/"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26062"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-00366-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00569-2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00386-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-1594"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016998"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1620948"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2019.07.001"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.76","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T12:42:42Z","timestamp":1736253762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/hem3.76"],"URL":"https:\/\/doi.org\/10.1002\/hem3.76","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"article-number":"e76"}}