{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T13:03:22Z","timestamp":1775048602002,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970147"],"award-info":[{"award-number":["81970147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170163"],"award-info":[{"award-number":["82170163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Philadelphia chromosome (Ph)\u2010like acute lymphoblastic leukemia (ALL) is recognized for its genetic and clinical diversity. In this study, we identified a novel high\u2010risk subset of Ph\u2010like ALL, characterized by the activation of oncogenic signaling and the inactivation of the tumor suppressor gene <jats:italic>IKZF1<\/jats:italic>, resulting in a dismal outcome. The association between cytogenetic aberrations and clinical features was assessed on a cohort of 191 patients with Ph\u2010like ALL. Our findings revealed that patients with inactivation of <jats:italic>IKZF1<\/jats:italic> combined with activation of oncogenic signaling (<jats:italic>CRLF2\/EPOR\/JAK2<\/jats:italic> rearrangements or <jats:italic>p\u2010CRKL\/p\u2010STAT5<\/jats:italic> high expression) had the worst outcome (3\u2010year overall survival [OS] of 28.8% vs. 80.1% for others, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; 2\u2010year event\u2010free survival [EFS] of 6.5% vs. 57.0% for others, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariable analysis demonstrated that this high\u2010risk feature was an independent inferior prognostic factor (adjusted hazard ratio for OS\u2009=\u20094.55, 95% confidence interval [CI]: 2.35\u20138.81, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; adjusted hazard ratio for EFS\u2009=\u20093.27, 95% CI: 1.99\u20135.39, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Allogeneic hematopoietic stem cell transplantation was associated with improved prognoses in patients within the high\u2010risk subgroup. In conclusion, this study identified a clinically distinct entity that possesses effective prognostic features and provides potential guidance for refining risk stratification in Ph\u2010like ALL.<\/jats:p>","DOI":"10.1002\/hem3.82","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T10:19:56Z","timestamp":1716286796000},"source":"Crossref","is-referenced-by-count":7,"title":["An integrated classification of tumor suppressor <i>IKZF1<\/i> inactivation and oncogenic activation in Philadelphia chromosome\u2010like acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4693-4855","authenticated-orcid":false,"given":"Zicong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology, Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Hematologic Diseases, Nanfang Hospital Southern Medical University 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Clinical Research Center for Hematologic Diseases, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Hematologic Diseases, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Hematologic Diseases, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of 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Hospital of Guangxi Medical University Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Hematologic Diseases, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifa","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Hematologic 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