{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:06:31Z","timestamp":1789247191047,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Brexucabtagene autoleucel (brexu\u2010cel) is an autologous CD19 CAR T\u2010cell product, approved for relapsed\/refractory (r\/r) mantle cell lymphoma (MCL). In ZUMA\u20102, brexu\u2010cel demonstrated impressive responses in patients failing \u22652 lines, including a bruton's tyrosine kinase inhibitor, with an overall and complete response rate of 93% and 67%, respectively. Here, we report our real\u2010world intention\u2010to\u2010treat (ITT) outcomes for brexu\u2010cel in consecutive, prospectively approved patients, from 12 institutions in the United Kingdom between February 2021 and June 2023, with a focus on feasibility, efficacy, and tolerability. Of 119 approved, 104 underwent leukapheresis and 83 received a brexu\u2010cel infusion. Progressive disease (PD) and\/or manufacturing (MF) were the most common reasons for failure to reach harvest and\/or infusion. For infused patients, best overall and complete response rates were 87% and 81%, respectively. At a median follow\u2010up of 13.3 months, median progression\u2010free survival (PFS) for infused patients was 21 months (10.1\u2013NA) with a 6\u2010 and 12\u2010month PFS of 82% (95% confidence interval [CI], 71\u201389) and 62% (95% CI, 49\u201373), respectively. \u2265Grade 3 cytokine release syndrome and neurotoxicity occurred in 12% and 22%, respectively. On multivariate analysis, inferior PFS was associated with male sex, bulky disease, ECOG PS\u2009&gt;\u20091 and previous MF. Cumulative incidence of non\u2010relapse mortality (NRM) was 6%, 15%, and 25% at 6, 12, and 24 months, respectively, and mostly attributable to infection. Outcomes for infused patients in the UK are comparable to ZUMA\u20102 and other real\u2010world reports. However, ITT analysis highlights a significant dropout due to PD and\/or MF. NRM events warrant further attention.<\/jats:p>","DOI":"10.1002\/hem3.87","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T05:49:00Z","timestamp":1718257740000},"source":"Crossref","is-referenced-by-count":35,"title":["Brexucabtagene autoleucel for relapsed or refractory mantle cell lymphoma in the United Kingdom: A real\u2010world intention\u2010to\u2010treat analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2702-397X","authenticated-orcid":false,"given":"Maeve A.","family":"O'Reilly","sequence":"first","affiliation":[{"name":"University College London Hospital London UK"},{"name":"University College London Cancer Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wilson","sequence":"additional","affiliation":[{"name":"University College London and CRUK Cancer Trials Centre London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Burns","sequence":"additional","affiliation":[{"name":"University Hospital Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4952-2550","authenticated-orcid":false,"given":"Andrea","family":"Kuhnl","sequence":"additional","affiliation":[{"name":"Kings College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Seymour","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospital Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Uttenthal","sequence":"additional","affiliation":[{"name":"Cambridge University Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Besley","sequence":"additional","affiliation":[{"name":"University Hospital Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Alajangi","sequence":"additional","affiliation":[{"name":"University Hospital Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Creasey","sequence":"additional","affiliation":[{"name":"Newcastle upon Tyne Hospitals Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankara","family":"Paneesha","sequence":"additional","affiliation":[{"name":"University Hospital Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathon","family":"Elliot","sequence":"additional","affiliation":[{"name":"The Christie NHS foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-309X","authenticated-orcid":false,"given":"Carlos","family":"Gonzalez Arias","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Iyengar","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Beatson West of Scotland Cancer Centre Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Delaney","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospital Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Rubio","sequence":"additional","affiliation":[{"name":"Manchester Royal Infirmary Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lambert","sequence":"additional","affiliation":[{"name":"University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Begg","sequence":"additional","affiliation":[{"name":"Cambridge University Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Boyle","sequence":"additional","affiliation":[{"name":"Kings College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen P. L.","family":"Cheok","sequence":"additional","affiliation":[{"name":"University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham P.","family":"Collins","sequence":"additional","affiliation":[{"name":"Oxford University Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Roddie","sequence":"additional","affiliation":[{"name":"University College London Hospital London UK"},{"name":"University College London Cancer Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Johnson","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospital Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Kings College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.5904"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.2466"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.2977.2977"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1026902"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-779736"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0209-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-673145"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17363"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15567"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18519"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914347"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02370"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01658-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006922"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01797"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27056"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18209"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18378"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-793760"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.09.013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000712"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14870"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.205229"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011489"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001837"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009019"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02104"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003001"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00562"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011992"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-139611"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00017"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-178834"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18831"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012392"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2020.03.011"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-165031"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2212098"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-148626"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01288-9"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18810"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2248329"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016175"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00184-7"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-022-01240-0"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020578"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004000"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02214"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.87","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T07:40:57Z","timestamp":1736235657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/hem3.87"],"URL":"https:\/\/doi.org\/10.1002\/hem3.87","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"article-number":"e87"}}