{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:09:33Z","timestamp":1760645373662,"version":"3.30.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":12480,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The infusion of a closely related derivative of bilirubin, its dimethyl diester (DME), into jaundiced (<jats:italic toggle=\"yes\">jj<\/jats:italic>) Gunn rats was associated with biliary excretion of mono-and diglucuronides of bilirubin. <jats:italic toggle=\"yes\">In vitro<\/jats:italic> incubation of DME with liver microsomes from <jats:italic toggle=\"yes\">jj<\/jats:italic> rats demonstrated sequential demethylation and glucuronidation of DME. Liver microsomes from a patient with the Crigler-Najjar syndrome were unable to form glucuronides of bilirubin <jats:italic toggle=\"yes\">in vitro<\/jats:italic> unless DME was used as substrate. The results suggest that the deficiency in Gunn rats and in the Crigler-Najjar syndrome may be due to a structural defect in the microsomal matrix which contains glucuronyl transferase. This interpretation envisions a microenvironment of the transferase enzyme which is either impermeable to bilirubin or induces conformational changes which interfere with glucuronidation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840010405","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:42:00Z","timestamp":1172943720000},"page":"307-315","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["The presence of a microsomal UDP-glucuronyl transferase for bilirubin in homozygous jaundiced gunn rats and in the crigler-najjar syndrome"],"prefix":"10.1097","volume":"1","author":[{"given":"Gerard B.","family":"Odell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio O.","family":"Cukier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn R.","family":"Gourley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840010405-BIB1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1172\/JCI103702","volume":"37","author":"Schmid","year":"1958","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840010405-BIB2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/7.4.250","volume":"7","author":"Arias","year":"1959","journal-title":"J Histochem Cytochem"},{"key":"10.1002\/hep.1840010405-BIB3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1203\/00006450-197110000-00007","volume":"5","author":"Strebel","year":"1971","journal-title":"Pediat Res"},{"key":"10.1002\/hep.1840010405-BIB4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF00486069","volume":"9","author":"Puukka","year":"1973","journal-title":"Biochem Genetics"},{"key":"10.1002\/hep.1840010405-BIB5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1542\/peds.10.4.397","volume":"10","author":"Crigler","year":"1952","journal-title":"Pediatrics"},{"key":"10.1002\/hep.1840010405-BIB6","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1542\/peds.23.5.903","volume":"23","author":"Childs","year":"1959","journal-title":"Pediatrics"},{"key":"10.1002\/hep.1840010405-BIB7","first-page":"153","volume":"4","author":"Szabo","year":"1963","journal-title":"Acta Paediatr Hung"},{"key":"10.1002\/hep.1840010405-BIB8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1073\/pnas.73.2.289","volume":"73","author":"Nakata","year":"1976","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840010405-BIB9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1432-1033.1979.tb13155.x","volume":"98","author":"Bock","year":"1979","journal-title":"Eur J Biochem"},{"key":"10.1002\/hep.1840010405-BIB10","first-page":"273","volume":"5","author":"Del Villar","year":"1977","journal-title":"Drug Metab Dispos"},{"key":"10.1002\/hep.1840010405-BIB11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/bj1740485","volume":"174","author":"Wishart","year":"1978","journal-title":"Biochem J"},{"key":"10.1002\/hep.1840010405-BIB12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-291X(77)91298-0","volume":"75","author":"Wishart","year":"1977","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1002\/hep.1840010405-BIB13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-5793(80)80777-0","volume":"111","author":"Burchell","year":"1980","journal-title":"FEBS Letters"},{"key":"10.1002\/hep.1840010405-BIB14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1042\/bj1910155","volume":"191","author":"Weatherill","year":"1980","journal-title":"Biochem J"},{"key":"10.1002\/hep.1840010405-BIB15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/978-1-4684-2655-7_12","volume-title":"The enzymes of biological membranes","volume":"2","author":"Zakim","year":"1976","unstructured":"The effects of lipid-protein interactions on the kinetic parameters of microsomal UDP-glucuronyl transferase. 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