{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:05:59Z","timestamp":1787699159386,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":12418,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Hepatoma cells isolated from rats after administration of a carcinogen, diethylnitrosamine, and propagated in culture, contained a genetically stable cytoskeletal abnormality resembling Mallory bodies. These juxtanuclear aggregates of intermediate-sized filaments were maintained in carcinomas produced in nude mice after inoculation of uncloned mass cultures and a cloned subculture. Paraffin and frozen sections of these tumors revealed acentric nuclei and a glassy hyalin-type cytoplasmic lesion which stained pink with hematoxylin-eosin and blue with Mallory\u2019s aniline blue stain. The cells in culture and in the tumor sections were strongly positive for \u03b3-glutamyl transpeptidase. Cryostat sections examined by indirect immunofluorescence microscopy with antisera to purified bovine hoof prekeratin, desmosome-associated tonofilaments from bovine muzzle, and murine vimentin, as well as transmission electron microscopy revealed the presence of juxtanuclear aggregates of intermediate-sized filaments. All characteristics previously reported for the tissue culture cell line were stably maintained in the tumor tissue. These results suggest that the Mallory body-containing cells frequently observed in man in alcoholic hepatitis and other degenerative liver diseases could, under appropriate environmental \u201cpromoting\u201d conditions, be precursor cells in focal hepatocellular carcinoma formation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840010507","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:40:36Z","timestamp":1172943636000},"page":"408-415","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Mallory body-like abnormalities in carcinomas induced by cultured transformed rat liver cells"],"prefix":"10.1097","volume":"1","author":[{"given":"Ellen","family":"Borenfreund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"DeHarven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Garra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840010507-BIB1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3835(77)95126-6","volume":"3","author":"Borenfreund","year":"1977","journal-title":"Cancer Lett"},{"key":"10.1002\/hep.1840010507-BIB2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3109\/00365517809108427","volume":"38","author":"Borenfreund","year":"1978","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840010507-BIB3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1749-6632.1980.tb29539.x","volume":"349","author":"Borenfreund","year":"1980","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840010507-BIB4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/jnci\/64.2.323","volume":"64","author":"Borenfreund","year":"1980","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/hep.1840010507-BIB5","first-page":"69","volume":"22","author":"Mallory","year":"1911","journal-title":"Bull Johns Hopkins Hosp"},{"key":"10.1002\/hep.1840010507-BIB6","first-page":"113","volume-title":"Alcoholic liver pathology","author":"French","year":"1975","unstructured":"The Mallory body in the pathogenesis of alcoholic liver disease. In: , , eds. Alcoholic liver pathology. Toronto: House of Lind, 1975: 113\u2013143."},{"key":"10.1002\/hep.1840010507-BIB7","first-page":"77","volume":"20","author":"Denk","year":"1979","journal-title":"Int Rev Exp Pathol"},{"key":"10.1002\/hep.1840010507-BIB8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/hep.1840010113","volume":"1","author":"French","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840010507-BIB9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-4827(80)90428-0","volume":"127","author":"Borenfreund","year":"1980","journal-title":"Exp Cell Res"},{"key":"10.1002\/hep.1840010507-BIB10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-4827(79)90418-X","volume":"123","author":"Franke","year":"1979","journal-title":"Exp Cell Res"},{"key":"10.1002\/hep.1840010507-BIB11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1432-0436.1979.tb01010.x","volume":"14","author":"Franke","year":"1979","journal-title":"Differentiation"},{"key":"10.1002\/hep.1840010507-BIB12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0014-4827(78)90466-4","volume":"116","author":"Franke","year":"1978","journal-title":"Exp Cell Res"},{"key":"10.1002\/hep.1840010507-BIB13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0309-1651(78)90068-1","volume":"2","author":"Freundenstein","year":"1978","journal-title":"Cell Biol Intern Reports"},{"key":"10.1002\/hep.1840010507-BIB14","first-page":"234","volume-title":"Staining methods, histologic and histochemical","author":"McManus","year":"1960","unstructured":"In: Staining methods, histologic and histochemical. 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Hoeber, Inc., 1960: 234."},{"key":"10.1002\/hep.1840010507-BIB15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/17.8.517","volume":"17","author":"Rutenburg","year":"1969","journal-title":"J Histochem Cytochem"},{"key":"10.1002\/hep.1840010507-BIB16","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1073\/pnas.76.6.2813","volume":"76","author":"Sun","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840010507-BIB17","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1073\/pnas.77.8.4948","volume":"77","author":"Bannash","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840010507-BIB18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/hep.1840010103","volume":"1","author":"Denk","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840010507-BIB19","first-page":"800","volume":"39","author":"Borenfreund","year":"1979","journal-title":"Cancer Res"},{"key":"10.1002\/hep.1840010507-BIB20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/jnci\/57.3.591","volume":"57","author":"Fiala","year":"1976","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/hep.1840010507-BIB21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/jnci\/55.3.579","volume":"55","author":"Kalengayi","year":"1975","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/hep.1840010507-BIB22","first-page":"823","volume":"38","author":"Cameron","year":"1978","journal-title":"Cancer Res"},{"key":"10.1002\/hep.1840010507-BIB23","first-page":"483","volume":"39","author":"Tinberg","year":"1978","journal-title":"Lab Invest"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840010507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198109000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:04:39Z","timestamp":1733051079000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198109000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840010507","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}