{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:40:31Z","timestamp":1733053231645,"version":"3.30.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":12418,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>This study was performed as an initial step in systematically defining the hepatic interactions between ethanol and opioids using a controlled <jats:italic toggle=\"yes\">in vitro<\/jats:italic> system. The acute effects of ethanol on the initial uptake and distribution of long- and short-acting narcotics were studied using isolated rabbit liver perfused with rabbit blood without or with ethanol. A pulse injection of 1.5 mg of <jats:sup>14<\/jats:sup>C-labeled narcotic [methadone, 1-\u03b1-acetylmethadol (LAAM), morphine, or meperidine] was made into the portal vein cannula followed by perfusion for 2 min. Radioactivity was determined in liver homogenates and subcellular fractions; methadone and its metabolites were measured by thin-layer chromatography with zonal scanning in each fraction. Ethanol preperfusion and concomitant ethanol perfusion did not effect hepatic uptake of methadone, LAAM, morphine, or meperidine. Although subcellular localization of morphine and meperidine differed from that of methadone and LAAM, perfusion with ethanol did not alter the acute hepatic uptake and distribution of any of the narcotics. These findings suggest that acute exposure to ethanol does not alter the acute hepatic disposition of narcotics.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840010509","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:40:36Z","timestamp":1172943636000},"page":"419-423","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Acute effects of ethanol on hepatic uptake and distribution of narcotics in the isolated perfused rabbit liver"],"prefix":"10.1097","volume":"1","author":[{"given":"Mary Jeanne","family":"Kreek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus A.","family":"Rothschild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Oratz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Mongelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C.","family":"Handley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840010509-BIB1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1126\/science.162.3854.690","volume":"162","author":"Rubin","year":"1968","journal-title":"Science"},{"key":"10.1002\/hep.1840010509-BIB2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0002-9343(70)80061-4","volume":"49","author":"Rubin","year":"1970","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840010509-BIB3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0006-2952(76)90224-0","volume":"25","author":"Kalant","year":"1976","journal-title":"Biochem Pharmacol"},{"key":"10.1002\/hep.1840010509-BIB4","doi-asserted-by":"crossref","first-page":"598","DOI":"10.7326\/0003-4819-77-4-598","volume":"77","author":"Kreek","year":"1972","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840010509-BIB5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/jama.1973.03220060039009","volume":"223","author":"Kreek","year":"1971","journal-title":"JAMA"},{"key":"10.1002\/hep.1840010509-BIB6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1749-6632.1976.tb27945.x","volume":"281","author":"Kreek","year":"1976","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840010509-BIB7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.1978.tb16769.x","volume":"311","author":"Kreek","year":"1978","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840010509-BIB8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/jama.1972.03210070041011","volume":"222","author":"Stimmel","year":"1972","journal-title":"JAMA"},{"key":"10.1002\/hep.1840010509-BIB9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0376-8716(78)90033-9","volume":"3","author":"Cushman","year":"1978","journal-title":"Drug & Alcohol Dependence"},{"key":"10.1002\/hep.1840010509-BIB10","first-page":"717","volume-title":"Factors affecting the action of narcotics","author":"Kreek","year":"1978","unstructured":"Effects of drugs and alcohol on opiate disposition and actions. In: , , eds. Factors affecting the action of narcotics. New York: Raven Press, 1978: 717\u2013740."},{"key":"10.1002\/hep.1840010509-BIB11","first-page":"123","volume":"207","author":"Borowsky","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/hep.1840010509-BIB12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1749-6632.1981.tb12789.x","volume":"362","author":"Kreek","year":"1981","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840010509-BIB13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.15288\/jsa.1979.40.7","volume":"40","author":"Whitehouse","year":"1979","journal-title":"J Stud Alcohol"},{"key":"10.1002\/hep.1840010509-BIB14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0016-5085(78)93770-8","volume":"75","author":"Kreek","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840010509-BIB15","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1172\/JCI105941","volume":"47","author":"Rothschild","year":"1968","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840010509-BIB16","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S0016-5085(19)32706-4","volume":"67","author":"Rothschild","year":"1974","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840010509-BIB17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/0016-5085(78)90242-1","volume":"74","author":"Oratz","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840010509-BIB18","first-page":"471","volume":"72","author":"Dole","year":"1972","journal-title":"NY State J Med"},{"key":"10.1002\/hep.1840010509-BIB19","first-page":"91","volume-title":"Statistical methods","author":"Snedecor","year":"1967","unstructured":"Statistical methods, sixth edition. Ames, Iowa: Iowa State University Press, 1967: 91\u201398."},{"key":"10.1002\/hep.1840010509-BIB20","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/00007611-197109000-00020","volume":"64","author":"Mannheimer","year":"1971","journal-title":"South Med J"},{"key":"10.1002\/hep.1840010509-BIB21","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1213\/00000539-197150060-00012","volume":"50","author":"Reier","year":"1971","journal-title":"Anesthesia and Analgesia"},{"key":"10.1002\/hep.1840010509-BIB22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0006-2952(76)90223-9","volume":"25","author":"Khanna","year":"1976","journal-title":"Biochem Pharmacol"},{"key":"10.1002\/hep.1840010509-BIB23","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/0024-3205(77)90223-5","volume":"20","author":"Whitehouse","year":"1977","journal-title":"Life Sci"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840010509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198109000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:04:30Z","timestamp":1733051070000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198109000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840010509","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}