{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:45:22Z","timestamp":1765079122664,"version":"3.30.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":12418,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Bone disease and low serum levels of 25-hydroxyvitamin D are prevalent in cholestatic syndromes such as primary biliary cirrhosis and biliary atresia. Defective hydroxylation, along with malabsorption of vitamin D, could be a factor in 25-hydroxyvitamin D depletion. To assess hepatic hydroxylation during experimental cholestasis, we studied vitamin D 25-hydroxylase activity in liver homogenates of rats after 7, 14, and 21 days of bile duct ligation. We have also studied the effects of bile acids on this enzyme <jats:italic toggle=\"yes\">in vitro.<\/jats:italic> Hepatic 25-hydroxylation was depressed after 7 days ligation in only 1 of 4 animals, but by 14 days, all animals showed a marked reduction with a mean decrease of 64% in specific activity. Total liver enzyme activity was reduced by 43% at 14 days. In the ligated animals, liver histology showed progressive bile stasis, focal necrosis, bile ductular proliferation, periductular and periportal inflammation, and fibrosis. Addition of bile acids to the <jats:italic toggle=\"yes\">in vitro<\/jats:italic> assay in concentrations approximating those found in cholestasis produced marked inhibition of vitamin D 25-hydroxylase activity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840010512","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:40:36Z","timestamp":1172943636000},"page":"436-440","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":20,"title":["Iepatic vitamin D 25-hydroxylase: Inhibition by bile duct ligation or bile salts"],"prefix":"10.1097","volume":"1","author":[{"given":"Erry J. G.","family":"Bolt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Sitrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray J.","family":"Favus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin H.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840010512-BIB1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0140-6736(76)92407-7","volume":"2","author":"Wagonfeld","year":"1976","journal-title":"Lancet"},{"key":"10.1002\/hep.1840010512-BIB2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0140-6736(76)92463-6","volume":"2","author":"Long","year":"1976","journal-title":"Lancet"},{"key":"10.1002\/hep.1840010512-BIB3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0140-6736(77)92166-3","volume":"1","author":"Skinner","year":"1977","journal-title":"Lancet"},{"key":"10.1002\/hep.1840010512-BIB4","first-page":"256","volume":"24","author":"Sonnenberg","year":"1977","journal-title":"Acta Hepato-Gastroenterol"},{"key":"10.1002\/hep.1840010512-BIB5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/gut.20.2.133","volume":"20","author":"Compston","year":"1979","journal-title":"Gut"},{"key":"10.1002\/hep.1840010512-BIB6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/gut.20.10.840","volume":"20","author":"Jung","year":"1979","journal-title":"Gut"},{"key":"10.1002\/hep.1840010512-BIB7","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0022-3476(76)81073-6","volume":"88","author":"Daum","year":"1976","journal-title":"J Pediatr"},{"key":"10.1002\/hep.1840010512-BIB8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1651-2227.1978.tb16274.x","volume":"67","author":"Seino","year":"1978","journal-title":"Acta Paediatr Scand"},{"key":"10.1002\/hep.1840010512-BIB9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1172\/JCI105327","volume":"45","author":"Thompson","year":"1966","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840010512-BIB10","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S0140-6736(77)92660-5","volume":"2","author":"Krawitt","year":"1977","journal-title":"Lancet"},{"key":"10.1002\/hep.1840010512-BIB11","first-page":"29","volume":"3","author":"Meyer","year":"1978","journal-title":"J Mol Med"},{"key":"10.1002\/hep.1840010512-BIB12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gut.20.7.559","volume":"20","author":"Barragry","year":"1979","journal-title":"Gut"},{"key":"10.1002\/hep.1840010512-BIB13","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/archpedi.1938.01980110019002","volume":"55","author":"Heyman","year":"1938","journal-title":"Am J Child"},{"key":"10.1002\/hep.1840010512-BIB14","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0016-5085(19)33225-1","volume":"63","author":"Greim","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840010512-BIB15","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0016-5085(19)33226-3","volume":"63","author":"Greim","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840010512-BIB16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0006-2944(73)90032-X","volume":"8","author":"Greim","year":"1973","journal-title":"Biochem Med"},{"key":"10.1002\/hep.1840010512-BIB17","first-page":"53","volume-title":"The bile acids","volume":"3","author":"Greim","year":"1976","unstructured":"Bile acids in hepato-biliary diseases. 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