{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:14:22Z","timestamp":1762917262134,"version":"3.30.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":12176,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Fasting levels of cholic acid conjugates were determined by radioimmunoassay in the serum of 24 patients with extensively documented Gilbert's syndrome and in 98 healthy controls without unconjugated hyperbilirubinemia. The Gilbert's syndrome patients studied included all three subtypes, as determined from studies of the plasma disappearance kinetics of sulf obromophthalein and indocyanine green. Although patients with structural liver disease severe enough to produce hyperbilirubinemia almost invariably have elevated fasting serum levels of cholic acid conjugates, values were normal in each of the Gilbert's syndrome patients, including patients with metabolic abnormalities in sulfobromophthalein and indocyanine green transport. It is concluded that the measurement of fasting serum levels of cholic acid conjugates is a useful adjunct to the diagnosis of Gilbert's syndrome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840020309","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T12:54:22Z","timestamp":1278334462000},"page":"340S-343S","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Normal Fasting\u2013State Levels of Serum Cholyl\u2013Conjugated Bile Acids in Gilbert's Syndrome: An Aid to the Diagnosis"],"prefix":"10.1097","volume":"2","author":[{"given":"John M.","family":"Vierling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Berk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan F.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan W.","family":"Wolkoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce F.","family":"Scharschmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840020309-BIB1|cit1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1172\/JCI101304","article-title":"Latent liver disease in persons recovered from catarrhal jaundice and in otherwise normal medical students as revealed by the bilirubin excretion test","volume":"21","author":"Kornberg","year":"1942","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840020309-BIB2|cit2","first-page":"1009","volume-title":"Metabolic control and disease","author":"Berk","year":"1979"},{"key":"10.1002\/hep.1840020309-BIB3|cit3","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0140-6736(77)92226-7","article-title":"Does Gilbert's disease exist?","volume":"1","author":"Bailey","year":"1977","journal-title":"Lancet"},{"key":"10.1002\/hep.1840020309-BIB4|cit4","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0016-5085(19)33296-2","article-title":"Defective BSP clearance in patients with constitutional hepatic dysfunction (Gilbert's syndrome)","volume":"63","author":"Berk","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020309-BIB5|cit5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0016-5085(76)80151-5","article-title":"Abnormal hepatic transport of indocyanine green in Gilbert's syndrome","volume":"70","author":"Martin","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020309-BIB6|cit6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0016-5085(19)33005-7","article-title":"Radioimmunoassay of conjugated cholyl bile acid in serum","volume":"65","author":"Simmonds","year":"1973","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020309-BIB7|cit7","first-page":"499","article-title":"Preparation and properties of specifically labeled radiochemically stable 3H-bilirubin","volume":"75","author":"Howe","year":"1970","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840020309-BIB8|cit8","first-page":"905","article-title":"Studies on the biosynthetic production of bilirubin-C'4: an improved method utilizing delta-aminolevulinic acid-4\u221214C in dogs","volume":"68","author":"Barett","year":"1966","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840020309-BIB9|cit9","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1172\/JCI106184","article-title":"Studies of bilirubin kinetics in normal adults","volume":"48","author":"Berk","year":"1969","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840020309-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJM195406172502402","article-title":"Studies of red cell volume and turnover using radi-ochromium. 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