{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T05:02:31Z","timestamp":1733115751412,"version":"3.30.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":12115,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>During a 33\u2013month period, 295 patients with acute viral hepatitis were admitted to a state hospital for civil servants and their dependents in Sao Paulo, Brazil. Seventy\u2013nine per cent (232) were HBsAg negative. To define the contribution of non\u2013A, non\u2013B viral hepatitis to hepatitis morbidity in this population, further serological studies were performed in 147 confirmed HBsAg\u2013negative patients. One hundred and twelve (76%) were serologically classified as hepatitis A based on identification of IgM antibody to hepatitis A virus. Thirty patints (20%) without IgM antibody to hepatitis A virus, HBsAg, or anti\u2013HBc were categorized as the non\u2013A, non\u2013B hepatitis group. The remaining five patients had probable hepatitis B (IgM antibody to hepatitis A virus negative, HBsAg negative, anti\u2013HBs negative but anti\u2013HBc positive). These data suggest that all three etiological forms of viral hepatitis are endemic in Sao Paulo.<\/jats:p>\n            <jats:p>Epidemiological, clinical, and laboratory features were compared in the hepatitis A and non\u2013A, non\u2013B hepatitis groups. Patients with non\u2013A, non\u2013B hepatitis were significantly older than patients with hepatitis A (mean age \u00b1 S.D.: 30 \u00b1 22 years vs. 9 \u00b1 9 years, p &lt; 0.001). Contact with hepatitis or jaundice was recognized in 26 (23%) of 112 hepatitis A patients and 3 (10%) of 30 non\u2013A, non\u2013B patients, a difference which was not statistically significant. Parenteral exposures were identified in 13 (43%) of 30 patients with non\u2013A, non\u2013B hepatitis and 23 (21%) of the 112 hepatitis A patients. Blood transfusion in the 2 months preceding onset of illness was reported in 5 (17%) of the 30 non\u2013A, non\u2013B patients and in none of the hepatitis A group (p &lt; 0.001). Although prodromal symptoms and fever were more common in patients with hepatitis A, neither these nor other clinical features appeared to be distinguishing characteristics. Similarly, mean peak SGPT levels, peak SGPT levels of &gt; 1,000 HJ\/per liter, and the mean duration of SGPT elevations for each group were not significantly different. Mean peak serum bilirubin levels were slightly higher in the non\u2013A, non\u2013B group than in the hepatitis A group (7.6 \u00b1 8.0 mg per dl vs. 5.1 \u00b1 2.7, p &lt; 0.01) and peak bilirubin levels &gt; 10 mg per dl were found in 27% of the non\u2013A, non\u2013B group and 5% of the hepatitis A group (p &lt; 0.001). Whether the higher bilirubin levels reflect an agent\u2013related phenomenon or an older population of affected patients is uncertain.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840020409","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T12:59:53Z","timestamp":1278334793000},"page":"445S-448S","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Hepatitis A and Non\u2013A, Non\u2013B Viral Hepatitis in S\u00e3o Paulo, Brazil: Epidemiological, Clinical, and Laboratory Comparisons in Hospitalized Patients"],"prefix":"10.1097","volume":"2","author":[{"given":"Raymond S.","family":"Koff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio S.","family":"Pannuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo L.G.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt G.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules L.","family":"Dienstag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amato V.","family":"NETO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris C.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840020409-BIB1|cit1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM197504102921502","article-title":"Transfusion associated hepatitis not due to viral hepatitis type A or B","volume":"292","author":"Feinstone","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840020409-BIB2|cit2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/infdis\/142.3.400","article-title":"Transfusion-transmitted viruses study: experimental evidence for two non-A, non-B hepatitis agents","volume":"142","author":"Hollinger","year":"1980","journal-title":"J Infect Dis"},{"key":"10.1002\/hep.1840020409-BIB3|cit3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0016-5085(81)90659-4","article-title":"Demonstration of two different types of non-A, non-B hepatitis by reinjection and cross-challenge studies in chimpanzees","volume":"81","author":"Yoshizawa","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020409-BIB4|cit4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.7326\/0003-4819-92-4-539","article-title":"Post-transfusion hepatitis: current perspectives","volume":"92","author":"Aach","year":"1980","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840020409-BIB5|cit5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3181\/00379727-161-40545","article-title":"Differential serodiagnosis of sporadic acute viral hepatitis","volume":"161","author":"Papaevangelou","year":"1979","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1002\/hep.1840020409-BIB6|cit6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/JCM.11.3.297-300.1980","article-title":"Etiological characterization of hepatitis B surface antigen-negative hepatitis among adult patients in Athens, Greece","volume":"11","author":"Mathiesen","year":"1980","journal-title":"J Clin Microbiol"},{"key":"10.1002\/hep.1840020409-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM197512252932606","article-title":"Evidence for viral hepatitis other than type A or B among persons in Costa 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Possibility of another human hepatitis virus distinct from posttransfusion non-A, non-B type","volume":"68","author":"Khuroo","year":"1980","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840020409-BIB13|cit13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/00365548.1981.11690359","article-title":"Serodiagnosis of viral hepatitis A by a solid-phase radioimmunoassay specific for IgM antibodies","volume":"13","author":"Hansson","year":"1981","journal-title":"Scand J Infect Dis"},{"key":"10.1002\/hep.1840020409-BIB14|cit14","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3109\/00365527809182206","article-title":"The epidemiological pattern of hepatitis A, B, and non-A, non-B in Sweden","volume":"13","author":"Norkrans","year":"1978","journal-title":"Scand J Gastroenterol"},{"key":"10.1002\/hep.1840020409-BIB15|cit15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJM198007173030307","article-title":"Chronic non-A, non-B hepatitis carrier state. Transmissible agent documented in one patient over a six-year period","volume":"303","author":"Tabor","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840020409-BIB16|cit16","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0016-5085(77)80208-4","article-title":"Development of chronic liver disease after acute non-A, non-B post-transfusion hepatitis: role of b\u0303-globulin prophylaxis in its prevention","volume":"72","author":"Knodell","year":"1977","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020409-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-91-1-1","article-title":"The chronic sequelae of non-A, non-B hepatitis","volume":"91","author":"Berman","year":"1979","journal-title":"Ann Intern Med"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840020409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198207000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:10:26Z","timestamp":1733051426000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198207000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840020409","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1982,7]]}}}