{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:40:29Z","timestamp":1790836829371,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":12115,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,7]]},"abstract":"\n \n A commercial radioimmunoassay was adapted to detect serum Dane particle\u2013associated HBeAg in patients whose sera contained the homologous antibody. HBeAg was released from Dane particles with guanidine HC1.<\/jats:p>\n Dane particles were separated from anti\u2013HBe by gel\u2013filtration (Sepharose 4B) and ultracentrifu\u2013gation of the eluate. Dane particle\u2013HBeAg was tested in 45 HBsAg carriers with anti\u2013HBe and was present in 8 (18%) carriers, all of whom had chronic liver disease. By contrast, HBeAg was not found in 10 carriers with normal liver histology. Serum or liver HBeAg was found in 6 of 8 patients with Dane particle\u2013HBeAg. None of the carriers without Dane particle\u2013HBeAg had other markers of hepatitis B virion synthesis.<\/jats:p>\n We conclude that Dane particle\u2013HBeAg provides a sensitive index of active hepatitis B virus replication, a guide to the presence of chronic hepatitis in HBsAg carriers with anti\u2013HBe, and a noninvasive method to follow infection in these patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840020410","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T11:52:11Z","timestamp":1278330731000},"page":"449S-454S","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":21,"title":["Dane Particle\u2013Associated Hepatitis B E Antigen in Patients With Chronic Hepatitis B Virus Infection and Hepatitis B E Antibody"],"prefix":"10.1097","volume":"2","author":[{"given":"Giovanni","family":"Raimondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serafino","family":"Recchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lavarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Crivelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Rizzetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840020410-BIB1|cit1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jmv.1890020202","article-title":"Prevalence of hepatitis B e antigen and its antibody as detected by 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