{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T05:02:38Z","timestamp":1733115758035,"version":"3.30.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11992,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>To assess the pathogenetic mechanisms involved in the accumulation of copper in primary biliary cirrhosis (PBC), the kinetics of <jats:sup>64<\/jats:sup>Copper (<jats:sup>64<\/jats:sup>Cu) were studied in 6 healthy volunteers, 3 patients with PBC (Stages I to III) and a normal liver copper, and 7 patients with PBC (Stages II to IV) and a high liver copper. The kinetics of oral and i.v. administered <jats:sup>64<\/jats:sup>Cu in patients with a normal liver copper were similar to those in controls. In patients with a high liver copper, the initial disappearance rate from the plasma of i.v. administered <jats:sup>64<\/jats:sup>Cu was more rapid, the disappearance rate from the liver of <jats:sup>64<\/jats:sup>Cu taken up by this organ was slower, and the fecal excretion of <jats:sup>64<\/jats:sup>Cu less as compared with the two other groups of subjects. In addition, the fecal excretion of orally administered <jats:sup>64<\/jats:sup>Cu was less in these patients. Computation of the rate of absorption of orally administered <jats:sup>64<\/jats:sup>Cu revealed no differences between the three groups. Two of the patients with a high liver copper were decopperized by treatment with D\u2013penicillamine. In these patients, the disappearance rate of i.v. administered <jats:sup>64<\/jats:sup>Cu from the liver and the secondary reappearance rate of <jats:sup>64<\/jats:sup>Cu into plasma became normal; however, the fecal excretion of <jats:sup>64<\/jats:sup>Cu remained low. It is concluded that there is no pathognomonic alteration of copper metabolism in PBC, but that in some patients, copper accumulates in the liver due to decreased biliary excretion and increased clearance from the plasma, and that dilution of the tracer dose a large amount of stable copper is responsible for all abnormalities of <jats:sup>64<\/jats:sup>Cu kinetics encountered in PBC, except low fecal excretion, which is caused by impairment of biliary excretion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840020614","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T10:16:04Z","timestamp":1310724964000},"page":"822-827","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Kinetics of 64Copper in Primary Biliary Cirrhosis"],"prefix":"10.1097","volume":"2","author":[{"given":"Roelof A.","family":"Janssens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis J.A.","family":"Van Den Hamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840020614-BIB1|cit1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/0016-5085(78)90239-1","article-title":"Incorporation of radiocopper into ceruloplasmin in normal subjects, and in patients with primary biliary cirrhosis and Wilson's disease","volume":"74","author":"Vierling","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020614-BIB2|cit2","unstructured":"Hamlyn AN Hepple M Macklon AM Defective radiocopper incorporation in early primary biliary cirrhosis (PBC) 1980"},{"key":"10.1002\/hep.1840020614-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1136\/bmj.2.5371.1498","article-title":"Relation between cirrhosis and trace metal content of the liver with special reference to primary biliary cirrhosis and copper","volume":"2","author":"Hunt","year":"1963","journal-title":"Br Med J"},{"key":"10.1002\/hep.1840020614-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(68)91814-X","article-title":"Liver copper levels in liver disease","volume":"2","author":"Smallwood","year":"1968","journal-title":"Lancet"},{"key":"10.1002\/hep.1840020614-BIB5|cit5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1136\/bmj.3.5614.344","article-title":"Copper and manganese concentrations in biliary cirrhosis of the liver","volume":"3","author":"Worwood","year":"1968","journal-title":"Br Med J"},{"key":"10.1002\/hep.1840020614-BIB6|cit6","first-page":"816","article-title":"The effect of D-penicillamine on urinary copper excretion in primary biliary cirrhosis","volume":"69","author":"Deering","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020614-BIB7|cit7","first-page":"1185","article-title":"Kinetics of oral and intravenous radiocopper in normal subjects and patients with primary biliary cirrhosis","volume":"72","author":"Vierling","year":"1977","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020614-BIB8|cit8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/BF02519363","article-title":"Extended automated separation techniques in destructive neutron activation analysis: application to various biological materials, including human tissues and blood","volume":"37","author":"Tjioe","year":"1977","journal-title":"J Radioanal Chem"},{"key":"10.1002\/hep.1840020614-BIB9|cit9","first-page":"552","volume-title":"Wissenschaftliche Tabellen","author":"Diem","year":"1969"},{"key":"10.1002\/hep.1840020614-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0016-5085(19)32704-0","article-title":"Copper and primary biliary cirrhosis","volume":"67","author":"Fleming","year":"1974","journal-title":"AGastroenterology"},{"key":"10.1002\/hep.1840020614-BIB11|cit11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/00365521.1977.12031116","article-title":"Hepatic copper content, urinary copper excretion, and serum ceruloplasmin in liver disease","volume":"12","author":"Ritland","year":"1977","journal-title":"Scand J Gastroenterol"},{"key":"10.1002\/hep.1840020614-BIB12|cit12","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/jcp.31.8.784","article-title":"Histological demonstration of copper and copper-associated protein in chronic liver diseases","volume":"31","author":"Jain","year":"1978","journal-title":"J Clin Pathol"},{"key":"10.1002\/hep.1840020614-BIB13|cit13","first-page":"808","article-title":"Hepatic copper accumulation in primary biliary cirrhosis","volume":"69","author":"Benson","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840020614-BIB14|cit14","first-page":"587","article-title":"Asymptomatic primary biliary cirrhosis. 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