{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:34:43Z","timestamp":1759336483176,"version":"3.30.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11872,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,3]]},"abstract":"\n \n Hepatocytes isolated from 101 biopsies were examined for membrane\u2013bound IgG. The sera of the patients were tested for anti\u2013liver\u2013specific lipoprotein by radioimmunoassay and for liver membrane autoantibody (by indirect immunofluorescence on isolated rabbit hepatocytes. The seven patients with normal liver or minor nonspecific alterations were negative for membrane IgG and serum antibodies. Membrane IgG with granular distribution was found in 41 patients [21 hepatitis B virus\u2013related chronic active hepatitis (CAH), 3 cryptogenic CAH, 3 chronic persistent hepatitis, 6 prolonged viral hepatitis, 1 alcoholic cirrhosis, and 6 primary biliary cirrhosis]. Membrane IgG with linear fluorescence pattern was detected in 12 cases (4 autoimmune CAH, 3 HBsAg\u2013positive CAH, 2 alcoholic cirrhosis, 1 anti\u2013HBc positive CAH, 1 cryptogenic CAH, and 1 prolonged viral hepatitis). A strong association between granular IgG and serum HBsAg was found. Nuclear localization of IgG was found in 34 patients and correlated with the positivity of granular membrane IgG.<\/jats:p>\n The highest prevalence of anti\u2013liver\u2013specific lipoprotein was found in primary biliary cirrhosis and autoimmune CAH cases which were also positive for liver membrane autoantibody. No relationship was found between the presence of membrane IgG and circulating liver\u2013specific autoantibodies.<\/jats:p>\n Membrane IgG and anti\u2013liver\u2013specific lipoprotein correlated with the presence of moderate and severe portal inflammatory infiltration but not with piecemeal necrosis or transaminase levels. Eleven of the twelve patients with linear membrane IgG presented chronic active liver disease with moderate to severe signs of liver damage.<\/jats:p>\n Therefore, it is suggested that, while granular membrane IgGs are related to hepatitis B virus, antigenic expression on the hepatocyte surface and\/or the presence of immune complexes, linear membrane IgG could play a role in the immunopathogenesis of liver cell damage particularly in \u201cautoimmune\u201d cases which present high percentages of positive cells liver\u2013specific autoantibodies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840030204","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T11:59:28Z","timestamp":1278331168000},"page":"155-161","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Hepatocyte Membrane\u2013Bound Igg and Circulating Liver\u2013Specific Autoantibodies in Chronic Liver Disease: Relation to Hepatitis B Virus Serum Markers and Liver Histology"],"prefix":"10.1097","volume":"3","author":[{"given":"Riccardo","family":"Meliconi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Miglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria M.","family":"Stancari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Baraldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco G.","family":"Stefanini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Gasbarrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840030204-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197807062990101","article-title":"Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis","volume":"299","author":"Jensen","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840030204-BIB2|cit2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0016-5085(79)80163-8","article-title":"Occurrence and significance of antibody to liver-specific membrane lipoprotein by double antibody immunoprecipitation method in sera of patients with acute and chronic liver diseases","volume":"76","author":"Kakumu","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030204-BIB3|cit3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(76)91472-0","article-title":"Antibody-dependent cell-mediated (K cell) cytotoxicity against isolated he-patocytes in chronic active hepatitis","volume":"1","author":"Cochrane","year":"1976","journal-title":"Lancet"},{"key":"10.1002\/hep.1840030204-BIB4|cit4","first-page":"16","article-title":"Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg negative chronic active hepatitis","volume":"38","author":"Mieli Vergani","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840030204-BIB5|cit5","first-page":"509","article-title":"Studies on the pathogenesis of experimental chronic active hepatitis in rabbits. II. Demonstration of immunoglobulins on isolated hepatocytes","volume":"55","author":"Hopf","year":"1974","journal-title":"Br J Exp Pathol"},{"key":"10.1002\/hep.1840030204-BIB6|cit6","first-page":"1","article-title":"Studies on the pathogenesis of chronic inflammatory liver diseases. I. Membrane-fixed IgG on isolated hepatocytes from patients","volume":"22","author":"Hopf","year":"1975","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840030204-BIB7|cit7","first-page":"396","article-title":"Liver cell surface localization of hepatitis B antigen and of immunoglobulins in acute and chronic hepatitis and in liver cirrhosis","volume":"25","author":"Alberti","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840030204-BIB8|cit8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0016-5085(79)90267-1","article-title":"Relationship between membrane-bound immunoglobulins and viral antigens in liver cells from patients with hepatitis B virus infection","volume":"77","author":"Trevisan","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030204-BIB9|cit9","first-page":"381","article-title":"Purification and characterization of human liver-specific membrane lipoprotein (LSP)","volume":"27","author":"McFariane","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840030204-BIB10|cit10","first-page":"382","article-title":"Antibodies against human liver-specific protein (LSP) in acute and chronic viral hepatitis types A, B and non A, non B","volume":"46","author":"Meliconi","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840030204-BIB11|cit11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0016-5085(82)90007-5","article-title":"Core antigen-specific immunoglobulin G bound to the liver cell membrane in chronic hepatitis B","volume":"82","author":"Trevisan","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030204-BIB12|cit12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.4049\/jimmunol.117.2.639","article-title":"Demonstration of binding sites for IgG Fc and the third complement component (C3) on isolated hepatocytes","volume":"117","author":"Hopf","year":"1976","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840030204-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1136\/jcp.34.10.1076","article-title":"Localization of immunoglobulin on the liver cell surface in primary biliary cirrhosis","volume":"34","author":"Krogsgaard","year":"1981","journal-title":"J Clin Pathol"},{"key":"10.1002\/hep.1840030204-BIB14|cit14","first-page":"97","volume-title":"Virus and the liver","author":"Trevisan","year":"1980"},{"key":"10.1002\/hep.1840030204-BIB15|cit15","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1056\/NEJM197610212951701","article-title":"Type B hepatitis: the infectivity of blood positive for \u201ce\u201d antigen and DNA polymerase after accidental needlestick exposure","volume":"295","author":"Alter","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840030204-BIB16|cit16","first-page":"139","article-title":"Radioimmunoassay for hepatitis B \u201ce\u201d antigen (HBeAg) and antibody (anti-HBe): correlations with viral replication and prognostic value","volume":"41","author":"Baraldini","year":"1981","journal-title":"Vox Sang"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840030204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198303000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:09:35Z","timestamp":1733051375000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198303000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840030204","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1983,3]]}}}