{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:27:20Z","timestamp":1762295240865,"version":"3.30.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11872,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>To test the hypothesis that hyperinsulinism is responsible for reduced branched\u2013chain amino acids in cirrhotics, plasma amino acids were sequentially determined in 8 controls and 8 matched cirrhotics during continuous i.v. insulin infusion. An artificial endocrine pancreas which infused glucose was used to sustain euglycemia. Basal plasma insulin levels were high and branched\u2013chain amino acids were reduced in cirrhotics. Insulin infusion raised insulin levels to 3 to 4 times basal values. During the test, the decline in branched\u2013chain amino acids was markedly higher in controls who had similar steady\u2013state insulin levels. Not only did the level of branched\u2013chain amino acids in controls reach the values seen in cirrhotics after 60 min, but the levels continued to fall at a significantly higher rate throughout the second hour. Glucose consumption and the ratio of glucose infused\/steady\u2013state insulin\u2014a measure of tissue sensitivity to insulin\u2014were markedly reduced in cirrhotics and positively correlated with the decline in branched\u2013chain amino acids. In cirrhotics, insulin effects on carbohydrate and branched\u2013chain amino acid metabolism were reduced. Low branched\u2013chain amino acid levels in cirrhotics are not likely to depend only on hyperinsulinism.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840030208","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T12:00:16Z","timestamp":1278331216000},"page":"184-187","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Effect of Euglycemic Insulin Infusion on Plasma Levels of Branched\u2013Chain Amino Acids in Cirrhosis"],"prefix":"10.1097","volume":"3","author":[{"given":"Giulio","family":"Marchesini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Forlani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Dondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glampaolo","family":"Blanchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlncenzo","family":"Bua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pletro","family":"Vannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Plsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840030208-BIB1|cit1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/BF01333703","article-title":"Insulin and glucagon levels in liver cirrhosis: relationship with plasma amino acid imbalance of chronic hepatic encephalopathy","volume":"24","author":"Marchesini","year":"1979","journal-title":"Dig Sci"},{"key":"10.1002\/hep.1840030208-BIB2|cit2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0140-6736(75)91632-3","article-title":"Insulin, plasma amino acid imbalance, and hepatic coma","volume":"1","author":"Munro","year":"1975","journal-title":"Lancet"},{"key":"10.1002\/hep.1840030208-BIB3|cit3","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0140-6736(76)90541-9","article-title":"Insulin, glucagon, amino acid imbalance, and hepatic encephalopathy","volume":"2","author":"Soeters","year":"1976","journal-title":"Lancet"},{"key":"10.1002\/hep.1840030208-BIB4|cit4","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1172\/JCI106193","article-title":"Amino acid balance across tissue of the forearm in postabsorptive man. 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