{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:08:54Z","timestamp":1790230134096,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11872,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,3]]},"abstract":"\n \n Depot iron, ferritin iron, and ferritin protein were measured in 34 liver needle biopsy specimens obtained from patients with primary and secondary iron\u2013loading diseases.<\/jats:p>\n The patients were classified as idiopathic hemochromatosis (14), porphyria cutanea tarda (4), and iron\u2013loading anemias (16). With accumulation of depot iron, the amount of liver ferritin protein increased, however, the ratio of ferritin protein to depot iron fell at concentrations of depot iron in excess of 1,000 m\u00a8er gm of liver. The liver ferritin protein concentration was not influenced by the specific kind of the iron storage disorder. The mean iron content of ferritin molecules increased about 50% in profound iron overload.<\/jats:p>\n In low grade iron overload, the bulk of depot iron was present as ferritin; however, in subjects with heavy iron overload, depot iron consisted of approximately equal amounts of hemosiderin (nonferritin iron) and ferritin iron.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840030216","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T12:18:01Z","timestamp":1278332281000},"page":"232-235","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["The Amount of Ferritin and Hemosiderin in the Livers of Patients With Iron\u2013Loading Diseases"],"prefix":"10.1097","volume":"3","author":[{"given":"Floris M.J.","family":"Zuyderhoudt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan W.","family":"Sindram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joannes J.M.","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George G.A.","family":"Jorning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus","family":"Van Gool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840030216-BIB1|cit1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2141.1981.tb07269.x","article-title":"Ferritin polymers and the formation of hae-mosiderin","volume":"49","author":"Hoy","year":"1981","journal-title":"Br J Haematol"},{"key":"10.1002\/hep.1840030216-BIB2|cit2","unstructured":"Zuyderhoudt FMJ Uiterdijk HG J\u00f6rning GGA On the role of rat liver lysosomes in the degradation of intravenously injected rat liver ferritin. In: Hegenauer J, Saltman P, eds. Proteins of iron storage and transport 1982"},{"key":"10.1002\/hep.1840030216-BIB3|cit3","first-page":"193","article-title":"Hemosiderin: nature, formation and significance","volume":"22","author":"Wixom","year":"1980","journal-title":"Int Rev Exp Pathol"},{"key":"10.1002\/hep.1840030216-BIB4|cit4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0016-5085(81)90019-6","article-title":"Assessment of liver iron content in 271 patients: a reevaluation of direct and indirect methods","volume":"80","author":"Brissot","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030216-BIB5|cit5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jcp.16.2.101","article-title":"Iron storage in human disease","volume":"16","author":"Morgan","year":"1963","journal-title":"J Clin Pathol"},{"key":"10.1002\/hep.1840030216-BIB6|cit6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/jcp.21.1.35","article-title":"Significance for the diagnosis of iron overload of histoehemical and chemical iron in the liver of control subjects","volume":"21","author":"Weinfeld","year":"1968","journal-title":"J Clin Pathol"},{"key":"10.1002\/hep.1840030216-BIB7|cit7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2141.1980.tb08714.x","article-title":"Studies on the concentration and intracellular localization of iron proteins in liver biopsy specimens from patients with iron overload with special reference to their role in lysosomal disruption","volume":"44","author":"Selden","year":"1980","journal-title":"Br J Haematol"},{"key":"10.1002\/hep.1840030216-BIB8|cit8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0009-8981(78)90387-X","article-title":"A method for measurement of liver iron fractions in needle biopsy specimens and some results in acute liver disease","volume":"86","author":"Zuyderhoudt","year":"1978","journal-title":"Clin Chim Acta"},{"key":"10.1002\/hep.1840030216-BIB9|cit9","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0016-5085(80)90445-X","article-title":"Hepatic and serum ferritin concentrations in patients with idiopathic hemochromatosis","volume":"79","author":"Beaumont","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030216-BIB10|cit10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0009-8981(74)90375-1","article-title":"Measurement of the iron content in human liver specimens","volume":"50","author":"Van Eyk","year":"1974","journal-title":"Clin Chim Acta"},{"key":"10.1002\/hep.1840030216-BIB11|cit11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/gut.15.5.411","article-title":"Liver iron cencentration, stainable iron, and total body storage 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Physiol"},{"key":"10.1002\/hep.1840030216-BIB15|cit15","first-page":"489","article-title":"Iron overload in chang cell cultures: biochemical and morphological studies","volume":"59","author":"Jacobs","year":"1978","journal-title":"Br J Exp Pathol"},{"key":"10.1002\/hep.1840030216-BIB16|cit16","first-page":"138","article-title":"Some aspects of iron metabolism during acute viral hepatitis","volume":"29","author":"Hengeveld","year":"1982","journal-title":"Hepato-Gastroenter-ology"},{"key":"10.1002\/hep.1840030216-BIB17|cit17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/cs0580321","article-title":"Rat liver storage iron and plasma ferritin during D-galactosamine-HCl induced hepatitis","volume":"58","author":"Zuyderhoudt","year":"1980","journal-title":"Clin 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