{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:44:08Z","timestamp":1761101048942,"version":"3.30.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11811,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Biliary obstruction in the rat causes known biochemical and morphological abnormalities. These abnormalities might be caused simply by retention of biliary constituents or might require other factors such as high biliary pressure, interruption of the normal flux of fluid, ions, and other biliary constituents through the hepatocyte and\/or changes in intracellular concentrations, binding, and distribution of biliary constituents. We studied a choledochocaval (CC) fistula rat model characterized by complete biliary retention without bile stasis. CC fistula animals were compared with biliary obstructed rats over a 46-hr period. Bile flow and bile acid excretion rate reached high levels by hour 5 and remained high in CC fistula rats. Urinary bile acid excretion, shrinkage of the rapidly exchangeable bile acid pool, and serum bile acid and bilirubin concentrations were equivalent in the two models. Serum cholesterol concentration was higher and serum alkaline phosphatase and 5\u2032-nucleotidase activities lower in obstructed rats. The percentage of \u03b2-muricho-late rose and the percentage of cholate decreased in bile acid from obstructed rats. This was associated with increased microsomal 6 \u03b2-hydroxylase activity. Bile acid composition and microsomal 6 \u03b2-hydroxylase activity changed little in CC fistula rats. Morphological examination revealed greater damage in obstructed rat livers. These data indicate that factors other than simple retention of biliary constituents contribute to the abnormalities observed in extrahepatic biliary obstruction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840030317","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T13:06:22Z","timestamp":1278335182000},"page":"383-390","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Similarities and Differences Between Models of Extrahepatic Biliary Obstruction and Complete Biliary Retention without Obstruction in the Rat"],"prefix":"10.1097","volume":"3","author":[{"given":"William G. M.","family":"Hardison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin G.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Hatoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Miyai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840030317-BIB1|cit1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0009-8981(76)90149-2","article-title":"A simple batch adsorption procedure for the isolation of sulfated and non-sulfated bile acids from serum","volume":"73","author":"Van Berge Henegouwen","year":"1976","journal-title":"Clin Chim Acta"},{"key":"10.1002\/hep.1840030317-BIB2|cit2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-2275(20)36815-2","article-title":"Measurement of sulfated and nonsulfated bile acids in human serum and urine","volume":"15","author":"Makino","year":"1974","journal-title":"J Lipid Res"},{"key":"10.1002\/hep.1840030317-BIB3|cit3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0016-5085(19)33225-1","article-title":"Mechanisms of cholestasis 5. Bile acids in normal rat livers and in those after bile duct ligation","volume":"63","author":"Greim","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030317-BIB4|cit4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/bj0570595","article-title":"The purification of alkaline phosphatase of animals tissues","volume":"57","author":"Morton","year":"1954","journal-title":"Biochem J"},{"key":"10.1002\/hep.1840030317-BIB5|cit5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000458774","article-title":"Hepatic alkaline phosphatase isoenzymes: isolation, characterization and differential alteration","volume":"22","author":"Simon","year":"1977","journal-title":"Enzyme"},{"key":"10.1002\/hep.1840030317-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0016-5085(72)80120-3","article-title":"Disparate responses of serum and hepatic alkaline phosphatase and 5'-nucleotidase to bile duct obstruction in the rat","volume":"62","author":"Righetti","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030317-BIB7|cit7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0009-8981(62)90063-3","article-title":"Quantitative separation and determination of bilirubin and conjugated bilirubin in human serum","volume":"7","author":"Weber","year":"1962","journal-title":"Clin Chim Acta"},{"key":"10.1002\/hep.1840030317-BIB8|cit8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1152\/ajplegacy.1972.222.1.61","article-title":"Micellar theory of biliary cholesterol excretion","volume":"222","author":"Hardison","year":"1972","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840030317-BIB9|cit9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0039-128X(73)90013-5","article-title":"Effect of biliary obstruction on formation and metabolism of bile acids in rat","volume":"22","author":"Danielsson","year":"1973","journal-title":"Steroids"},{"key":"10.1002\/hep.1840030317-BIB10|cit10","first-page":"249","article-title":"Subcellular pathology of rat liver in cholestasis and choleresis induced by bile salts. I. Effects of lithocholic, 3-beta-hydroxy-5-cholenoic, cholic and de-hydrocholic acids","volume":"36","author":"Miyai","year":"1977","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840030317-BIB11|cit11","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1152\/ajplegacy.1974.226.4.776","article-title":"Primate biliary physiology. IX. Effects of acute biliary obstruction on biliary lipid metabolism in the monkey","volume":"226","author":"Redinger","year":"1974","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840030317-BIB12|cit12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/S0016-5085(71)80089-6","article-title":"Mechanism of cholestasis. 4. Structural and biochemical changes in the liver and serum in rats after bile duct ligation","volume":"60","author":"Schaffner","year":"1971","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030317-BIB13|cit13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0016-5085(19)32475-8","article-title":"Scanning electron microscopy of the rat liver. Studies of the effect of taurolithocholate and other models of cholestasis","volume":"69","author":"Layden","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030317-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0016-5085(76)80057-1","article-title":"Morphometric analysis of rat hepatocytes after total biliary obstruction","volume":"1","author":"Jones","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030317-BIB15|cit15","first-page":"220","article-title":"Morphologic changes of the junctional complex of the hepatocytes in rat liver after bile duct ligation","volume":"59","author":"deVos","year":"1978","journal-title":"Br J Exp Pathol"},{"key":"10.1002\/hep.1840030317-BIB16|cit16","first-page":"141","volume-title":"Intra-hepatic cholestasis","author":"Dioguardi","year":"1975"},{"key":"10.1002\/hep.1840030317-BIB17|cit17","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3181\/00379727-133-34548","article-title":"Alteration of microsomal biotransformation in the liver in cholestasis","volume":"133","author":"Hutterer","year":"1970","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1002\/hep.1840030317-BIB18|cit18","first-page":"G337","article-title":"Nature of bile acid maximum secretory rate in the rat","volume":"241","author":"Hardison","year":"1981","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840030317-BIB19|cit19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0022-2275(20)35363-3","article-title":"Effect of bile duct ligation on bile acid metabolism in rats","volume":"22","author":"Kinugasa","year":"1981","journal-title":"J Lipid Res"},{"key":"10.1002\/hep.1840030317-BIB20|cit20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1172\/JCI107239","article-title":"Alteration of bile canalicular enzymes in cholestasis. A possible cause of bile secretory failure","volume":"52","author":"Simon","year":"1973","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840030317-BIB21|cit21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0016-5085(79)80078-5","article-title":"Induced synthesis of alkaline phosphatase by bile acids in rat liver cell culture","volume":"77","author":"Hatoff","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030317-BIB22|cit22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0016-5085(81)90123-2","article-title":"Bile acids modify alkaline phosphatase induction and bile secretion pressure after bile duct obstruction in the rat","volume":"80","author":"Hatoff","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030317-BIB23|cit23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/hep.1840020407","article-title":"Bile acid dependent excretion of alkaline phosphatase in rat bile","volume":"2","author":"Hatoff","year":"1982","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840030317-BIB24|cit24","first-page":"12","article-title":"Observations concerning the production and excretion of cholesterol in mammals. V. The relation of biliary retention of cholesterol, distention of the biliary tract, the shunting of bile to the vena cava and the removal of the gastrointestinal tract to the hypercholesterolemia consequent on biliary obstruction","volume":"95","author":"Byers","year":"1952","journal-title":"J Exp Med"},{"key":"10.1002\/hep.1840030317-BIB25|cit25","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1152\/ajplegacy.1960.199.6.991","article-title":"Effect of intravenous phospholipid and triton on lipids of normal and ethanol-treated rats","volume":"199","author":"DiLuzo","year":"1960","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840030317-BIB26|cit26","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1016\/S0021-9258(20)79894-7","article-title":"Induction of hepatic cholesterol synthesis in the rat by lecithin mesophase infusions","volume":"249","author":"Jakoi","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840030317-BIB27|cit27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2362.1979.tb00884.x","article-title":"Lipid deposition in kidneys in experimental liver disease a study in dogs with chole-dochocaval anastomosis","volume":"9","author":"Blornhoff","year":"1979","journal-title":"Eur J Clin Invest"},{"key":"10.1002\/hep.1840030317-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1172\/JCI108821","article-title":"Bile acid excretion: the alternate pathway in the hamster","volume":"60","author":"Galeazzi","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840030317-BIB29|cit29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0022-2275(20)41604-9","article-title":"Effects of ethynylestradiol on biliary excretion of bile acids, phosphotidylcholines and cholesterol in the bile fistula rat","volume":"18","author":"Kern","year":"1977","journal-title":"J Lipid Res"},{"key":"10.1002\/hep.1840030317-BIB30|cit30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0005-2760(79)90227-3","article-title":"Partitioning of bile acids into subcellular organelles and the in vivo distribution of bile acids in rat liver","volume":"573","author":"Strange","year":"1979","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/hep.1840030317-BIB31|cit31","first-page":"259","article-title":"Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study","volume":"36","author":"Nemchausky","year":"1977","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840030317-BIB32|cit32","first-page":"292","article-title":"Bile acid metabolism in mammals. Ultrastructural studies on the intrahepatic cholestasis induced by lithocholic and chenodeoxycholic acid in the rat","volume":"24","author":"Miyai","year":"1971","journal-title":"Lab Invest"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840030317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198305000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:08:27Z","timestamp":1733051307000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198305000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840030317","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1983,5]]}}}