{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:11:15Z","timestamp":1787317875182,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11811,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,5]]},"abstract":"\n \n \n The number of granulomas and loosely arranged epithelioid cell foci in wedge liver biopsy specimens of 39 patients with primary biliary cirrhosis were counted and correlated with other hepatic lesions. Granulomas and cell foci were present in 76.9 and 87.2% of the patients, respectively; their numbers varied greatly from case to case (mean \u00b1 S.D.: 2.4 \u00b1 3.4 per cm\n 2<\/jats:sup>\n and 4.7 \u00b1 5.5 per cm\n 2<\/jats:sup>\n of liver section; range: 0 to 18.5 per cm\n 2<\/jats:sup>\n and 0 to 23.3 per cm\n 2<\/jats:sup>\n , respectively) and decreased as bile duct loss progressed. There was positive correlation between the number of cell foci with the extent of florid duct lesions, and negative correlation with hepatic fibrosis and deposition of copper granules.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840030323","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T09:07:27Z","timestamp":1278320847000},"page":"423-427","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":46,"title":["Quantitation of Hepatic Granulomas and Epithelioid Cells in Primary Biliary Cirrhosis"],"prefix":"10.1097","volume":"3","author":[{"given":"Yasuni","family":"Nakanuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goroku","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840030323-BIB1|cit1","first-page":"288","volume-title":"Gastroenterology","volume":"III","author":"Berk","year":"1976"},{"key":"10.1002\/hep.1840030323-BIB2|cit2","first-page":"609","volume-title":"Progress in liver diseases","volume":"V","author":"Fauci","year":"1976"},{"key":"10.1002\/hep.1840030323-BIB3|cit3","first-page":"36","volume-title":"Liver biopsy interpretation","author":"Scheuer","year":"1980"},{"key":"10.1002\/hep.1840030323-BIB4|cit4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/gut.14.6.444","article-title":"Asymptomatic primary biliary 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exudate","volume":"8","author":"Spector","year":"1969","journal-title":"Int Rev Exp Pathol"},{"key":"10.1002\/hep.1840030323-BIB12|cit12","first-page":"36","article-title":"Granulomatous hypersensitivity","volume":"11","author":"Epstein","year":"1967","journal-title":"Prog Allergy"},{"key":"10.1002\/hep.1840030323-BIB13|cit13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/jcp.23.2.95","article-title":"Immunological and histological studies in primary biliary cirrhosis","volume":"23","author":"Hadziyannis","year":"1970","journal-title":"J Clin Pathol"},{"key":"10.1002\/hep.1840030323-BIB14|cit14","first-page":"269","volume-title":"Frontiers in liver disease","author":"Thomas","year":"1981"},{"key":"10.1002\/hep.1840030323-BIB15|cit15","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0140-6736(77)92666-6","article-title":"Is primary biliary cirrhosis an immune complex disease?","volume":"2","author":"Thomas","year":"1977","journal-title":"Lancet"},{"key":"10.1002\/hep.1840030323-BIB16|cit16","first-page":"285","article-title":"Primary biliary cirrhosis and the immune system","volume":"72","author":"Bodenheimer","year":"1979","journal-title":"Am J Gastroenterol"},{"key":"10.1002\/hep.1840030323-BIB17|cit17","first-page":"979","article-title":"Antibodies to cytoplasmic antigens in primary biliary cirrhosis and chronic active hepatitis","volume":"69","author":"Paronetto","year":"1967","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840030323-BIB18|cit18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0016-5085(82)80206-0","article-title":"Evidence against an immune complex pathogenesis of primary biliary cirrhosis (PBC)","volume":"83","author":"Goldberg","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840030323-BIB19|cit19","first-page":"209","volume-title":"Diseases of the liver and biliary 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