{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:06:35Z","timestamp":1758125195593,"version":"3.30.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11688,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Electron microscopic observations were carried out on five HBsAg carrier chimpanzees infected with delta (\u03b4) agent and two chimpanzees infected with human non-A, non-B hepatitis. The cytoplasmic tubular structures, which have been recognized in the liver of chimpanzees infected with human non-A, non-B hepatitis, were found also in the liver of HBsAg carrier chimpanzees infected with 5 agent. The quantity of the cytoplasmic structures in serial studies was associated with SGPT elevation rather than with expression of \u00b1 antigen in sera and liver tissues. This indicates that the cytoplasmic structures reflect a pathologic change of the hepatocytes in chimpanzees infected with \u00b1 agent or human non-A, non-B hepatitis. These and other similarities between the two agents suggest a similar nature.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840030502","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T12:10:48Z","timestamp":1278331848000},"page":"631-637","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":33,"title":["Cytoplasmic Tubular Structures in Liver of HBsAg Carrier Chimpanzees Infected with Delta Agent and Comparison with Cytoplasmic Structures in Non-A, Non-B Hepatitis"],"prefix":"10.1097","volume":"3","author":[{"given":"Tomoteru","family":"Kamimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ponzetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferruccio","family":"Bonino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Feinstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Gerin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840030502-BIB1|cit1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/gut.18.12.997","article-title":"Immunofluorescence detection of new antigen-antibody system (\u03b4\/anti \u03b4) associated to hepatitis B virus in liver and in serum of HBsAg carriers","volume":"18","author":"Rizzetto","year":"1977","journal-title":"Gut"},{"key":"10.1002\/hep.1840030502-BIB2|cit2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/path.1711280402","article-title":"An ultrastructural and immunohistochemical study on the \u03b4 antigen associated with the hepatitis B virus","volume":"128","author":"Canese","year":"1979","journal-title":"J Pathol"},{"key":"10.1002\/hep.1840030502-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0140-6736(79)91938-X","article-title":"Acute non-A, non-B hepatitis; specific ultrastructural alterations in endoplasmic reticulum of infected hepatocytes","volume":"1","author":"Jackson","year":"1979","journal-title":"Lancet"},{"key":"10.1002\/hep.1840030502-BIB4|cit4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1126\/science.451589","article-title":"Non-A, non-B hepatitis; ultrastructural evidence for two agents in experimentally infected chimpanzees","volume":"205","author":"Shimizu","year":"1979","journal-title":"Science"},{"key":"10.1002\/hep.1840030502-BIB5|cit5","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/infdis\/141.5.590","article-title":"Transmission of the hepatitis B virus-associated delta antigen to chimpanzees","volume":"141","author":"Rizzetto","year":"1980","journal-title":"J Infect Dis"},{"key":"10.1002\/hep.1840030502-BIB6|cit6","first-page":"986","article-title":"Incidence and significance of antibodies to delta antigen in hepatitis B virus infection","volume":"2","author":"Rizzetto","year":"1980","journal-title":"Lancet"},{"key":"10.1002\/hep.1840030502-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.4049\/jimmunol.121.5.1671","article-title":"Localization of hepatitis A antigen in liver tissue by peroxidase-conjugated antibody method: light and electron microscopic studies","volume":"121","author":"Shimizu","year":"1979","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840030502-BIB8|cit8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/hep.1840010504","article-title":"Electron microscopic studies of Dane particles in hepatocytes with special reference to intracellular development of Dane particles and their relation with HBeAg in serum","volume":"1","author":"Kamimura","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840030502-BIB9|cit9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/infdis\/144.6.588","article-title":"Non-A, non-B hepatitis in chimpanzees and marmosets","volume":"144","author":"Feinstone","year":"1981","journal-title":"J Infect Dis"},{"key":"10.1002\/hep.1840030502-BIB10|cit10","first-page":"492","article-title":"Tubular arrays in the endoplasmic reticulum in human tumor cells","volume":"24","author":"Uzman","year":"1971","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840030502-BIB11|cit11","first-page":"209","volume-title":"\u2018Endoplasmic reticulum\u2019 in ultrastructural pathology of the cell","author":"Ghadially","year":"1975"},{"key":"10.1002\/hep.1840030502-BIB12|cit12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1083\/jcb.24.1.57","article-title":"An electron microscope study of the development of a mouse hepatitis virus in tissue culture cells","volume":"24","author":"David-Ferreira","year":"1965","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840030502-BIB13|cit13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1128\/JVI.1.1.205-214.1967","article-title":"Electron microscopy of monkey kidney cell cultures infected with rubella virus","volume":"1","author":"Kim","year":"1967","journal-title":"J Virol"},{"key":"10.1002\/hep.1840030502-BIB14|cit14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1073\/pnas.60.2.489","article-title":"Infectious mononucleosis: detection of herpes like virus and reticular aggregates of small cytoplasmic particles in continuous lymphoid cell lines derived from peripheral blood","volume":"60","author":"Moses","year":"1968","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840030502-BIB15|cit15","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1083\/jcb.37.3.819","article-title":"Unique cytoplasmic membranes in Rous sarcoma virus-induced tumors of a subhuman primate","volume":"12","author":"Smith","year":"1968","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840030502-BIB16|cit16","first-page":"36","article-title":"Infectious canine hepatitis: a virologic and ultrastructural study","volume":"20","author":"Givan","year":"1969","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840030502-BIB17|cit17","first-page":"422","article-title":"Undulating tubules associated with endoplasmic reticulum in pathologic tissues","volume":"18","author":"Chandra","year":"1968","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840030502-BIB18|cit18","first-page":"1829","article-title":"Morphologic and serologic studies of transplanted human leucocyte culture (M 1) cells in laboratory animals","volume":"29","author":"Chandra","year":"1969","journal-title":"Cancer Res"},{"key":"10.1002\/hep.1840030502-BIB19|cit19","first-page":"195","volume-title":"Perspectives on virology XI","author":"Rizzetto","year":"1981"},{"key":"10.1002\/hep.1840030502-BIB20|cit20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF02899184","article-title":"Experimental non-A, non-B hepatitis: Four types of cytoplasmic alteration in hepatocytes of infected chimpanzees","volume":"33","author":"Pfeifer","year":"1980","journal-title":"Virchows Archiv B Cell Path"},{"key":"10.1002\/hep.1840030502-BIB21|cit21","unstructured":"Canese MG Rizzetto M Novara R Experimental delta infection in chimpanzees"},{"volume-title":"Pathology of hepatitis","year":"1983","author":"Popper","key":"10.1002\/hep.1840030502-BIB22|cit22"},{"key":"10.1002\/hep.1840030502-BIB23|cit23","first-page":"3","volume-title":"Viral hepatitis: 1981 International Symposium","author":"Purcell","year":"1982"},{"key":"10.1002\/hep.1840030502-BIB24|cit24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jmv.1890090208","article-title":"Radioimmunoassay detection of IgM antibodies to the HBV associated delta (\u03b4) antigen. Clinical significance in 8 infection","volume":"9","author":"Smedile","year":"1982","journal-title":"J Med Virol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840030502","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198309000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:04:16Z","timestamp":1733051056000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198309000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1983]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840030502","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1983,9]]}}}