{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:32:35Z","timestamp":1791246755396,"version":"4.1.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11566,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:sec><jats:title\/><jats:p>Venocclusive disease (VOD) of the liver, a fibrous obliteration of small hepatic venules, can be caused by chemoradiation therapy. We reviewed 255 consecutive patients undergoing bone marrow transplantation for malignancy during 1978 to 1980 in order to determine the incidence of VOD and the predisposing factors. Fifty-three of 255 patients met our criteria for VOD, for an incidence of 21%. Multivariate analysis showed that the most significant risk factors for VOD were age over 15, an underlying malignancy other than acute lymphocytic leukemia and hepatitis prior to transplantation. Patients with hepatitis had a 3. 4-fold risk of developing VOD, as compared to patients with normal SGOT values (p = 0.0004). Hepatitis in this setting is probably of non-A, non-B viral etiology and represents a relative contraindication to marrow transplantation because of enhanced toxicity from conditioning chemoradiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hep.1840040121","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:52:03Z","timestamp":1219413123000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":708,"title":["Venocclusive Disease of the Liver after Bone Marrow Transplantation: Diagnosis, Incidence, and Predisposing Factors"],"prefix":"10.1097","volume":"4","author":[{"given":"George B.","family":"Mcdonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard M.","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donnall E.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040121-BIB1","first-page":"406","volume-title":"The liver","author":"Bras","year":"1973"},{"key":"10.1002\/hep.1840040121-BIB2","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/0016-5085(80)90911-7","article-title":"An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation","volume":"79","author":"Shulman","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040121-BIB3","first-page":"5","article-title":"Fatal veno-occlusive disease of the liver after chemotherapy, whole-body irradiation and bone marrow transplantation for refractory acute leukaemia","volume":"55","author":"Jacobs","year":"1979","journal-title":"S Afr Med J"},{"key":"10.1002\/hep.1840040121-BIB4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0002-9343(80)90368-X","article-title":"Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation","volume":"68","author":"Woods","year":"1980","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840040121-BIB5","first-page":"369","article-title":"Pathology of the liver with bone marrow transplantation. 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