{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:14Z","timestamp":1760188994577,"version":"3.30.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11566,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>We describe the clinico-pathological characteristics of hepatic injury associated with the toxic-epidemic syndrome caused by the consumption of adulterated rapeseed oil. Of 842 toxic-epidemic syndrome patients admitted to our hospital between May, 1981, and January, 1982, 24.1% showed signs of liver involvement which was more frequent in women and in the fourth decade of life. No statistical significance was found in relation to alcohol consumption, treatment with potentially hepatotoxic antibiotics, or adult respiratory distress syndrome. Most (91.6%) patients with hepatic injury were asymptomatic; jaundice or abdominal pain was rarely noted. One patient died of acute liver failure following Budd-Chiari syndrome. Serum 7-glutamyl transpeptidase activity was raised in all cases, alkaline phosphatase in 94.6%, and less frequently lactate dehydrogenase (80%), SGPT (84.7%), and SGOT (76%). Serum total bilirubin was usually normal (89.2%). The histologic lesion was similar to drug-induced cholestatic hepatitis. Lamellar inclusions, canalicular injury, giant mitochondria, and hyperplasia of the smooth endoplasmic reticulum were seen by electron microscopy. Ultrastructural signs of cholestasis were common (78.9%). The pathogenesis of this lesion is unknown; however, because of similarities with chlorpromazine-induced cholestatic hepatitis, we suggest that a combination of hypersensitivity and intrinsic hepatotoxicity is a possible mechanism.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840040123","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:52:03Z","timestamp":1219413123000},"page":"131-139","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Hepatic Injury in the Toxic Epidemic Syndrome Caused by Ingestion of Adulterated Cooking Oil (Spain, 1981)"],"prefix":"10.1097","volume":"4","author":[{"given":"Jos\u00c9 A.","family":"Solis-Herruzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregorio","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Colina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Diego","family":"Morillas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Teresamu\u00f1oz-Yag\u00fce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Del Carmen Coca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusko","family":"Jelavic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040123-BIB1","first-page":"697","article-title":"Toxic epidemic syndrome, Spain, 1981. Description of a new systemic disease","volume":"2","author":"Rodriguez-Noriega","year":"1982","journal-title":"Lancet"},{"key":"10.1002\/hep.1840040123-BIB2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00496569","article-title":"Pathology of a new toxic syndrome caused by ingestion of adulterated oil in Spain","volume":"397","author":"Martinez-Tello","year":"1982","journal-title":"Virchows Arch (Pathol Anat)"},{"key":"10.1002\/hep.1840040123-BIB3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.9.2.409","article-title":"Improvements in epoxy resin embedding methods","volume":"9","author":"Luft","year":"1961","journal-title":"J Biophys Biochem Cytol"},{"key":"10.1002\/hep.1840040123-BIB4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1083\/jcb.17.1.208","article-title":"The use of lead citrate at high pH as an electronopaque stain in microscopy","volume":"17","author":"Reynolds","year":"1963","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840040123-BIB5","first-page":"97","volume-title":"Progress in liver diseases","author":"Desmet","year":"1972"},{"key":"10.1002\/hep.1840040123-BIB6","unstructured":"Coca C, Gomez P, Vargas C, et al. Screening de pacientes realizado en el sindrome toxico. Actas \u201cSimposium Nacional Sindrome Toxico\u201d. Madrid 11-12 Junio 1982. Ministerio de Sanidad y Consumo, 1982: 425-428."},{"key":"10.1002\/hep.1840040123-BIB7","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1002\/1097-0142(197106)27:6<1388::AID-CNCR2820270619>3.0.CO;2-0","article-title":"New observations on the Regan isoenzyme of alkaline phosphatase in cancer patients","volume":"27","author":"Nathanson","year":"1971","journal-title":"Cancer"},{"key":"10.1002\/hep.1840040123-BIB8","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/0016-5085(78)90718-7","article-title":"Mechanisms of chlorpromazine cholestasis hypersensitivity or toxic metabolite?","volume":"74","author":"Boyer","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040123-BIB9","first-page":"828","article-title":"Cellular pathophysiology of hepatitis","volume":"65","author":"Trump","year":"1976","journal-title":"Am J Clin Pathol"},{"key":"10.1002\/hep.1840040123-BIB10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0046-8177(73)80050-4","article-title":"Cellular changes in human disease","volume":"4","author":"Trump","year":"1973","journal-title":"Human Pathol"},{"key":"10.1002\/hep.1840040123-BIB11","first-page":"597","volume-title":"Progress in liver diseases","author":"Perez","year":"1972"},{"key":"10.1002\/hep.1840040123-BIB12","first-page":"283","article-title":"Hepatic injury associated with the phenothiazines. Clinicopathologic and follow-up study of 36 patients","volume":"93","author":"Ishak","year":"1972","journal-title":"Arch Pathol"},{"key":"10.1002\/hep.1840040123-BIB13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF02889557","article-title":"Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver","volume":"26","author":"Hruban","year":"1978","journal-title":"Virchow's Arch B (Cell Pathol)"},{"key":"10.1002\/hep.1840040123-BIB14","first-page":"233","volume-title":"Progress in surgical pathology","author":"Popper","year":"1981"},{"key":"10.1002\/hep.1840040123-BIB15","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0140-6736(81)90949-1","article-title":"Toxic-allergic syndrome caused by ingestion of rapeseed oil denatured with aniline","volume":"2","author":"Tabuenca","year":"1981","journal-title":"Lancet"},{"key":"10.1002\/hep.1840040123-BIB16","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0140-6736(81)90621-8","article-title":"Oleoanilides and Spanish oil poisoning","volume":"2","author":"Gordon","year":"1981","journal-title":"Lancet"},{"key":"10.1002\/hep.1840040123-BIB17","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0016-5085(78)90690-X","article-title":"Effects of chlorpromazine hydrochloride and its metabolites on Mg2+,- and Na+, K+-ATP-ase activities of canalicular-enriched rat liver plasma membrane","volume":"74","author":"Samuels","year":"1978","journal-title":"Gastroenterology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198401000-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:16:08Z","timestamp":1733051768000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198401000-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040123","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}