{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:37:09Z","timestamp":1770903429277,"version":"3.50.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11506,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>A Bolivian population of squirrel monkeys, <jats:italic toggle=\"yes\">Saimiri sciureus<\/jats:italic>, exhibits several features of Gilbert's syndrome in man, and is proposed as a nonhuman primate model of the condition. The Bolivian population was found to have higher fasting (40.6 \u00b1 2.7 <jats:italic toggle=\"yes\">\u03bcM;<\/jats:italic> mean \u00b1 S.E.) and postcibal (9.9 \u00b1 0.9 <jats:italic toggle=\"yes\">\u03bcM)<\/jats:italic> plasma unconjugated bilirubin concentrations (p &lt; 0.001) than a closely related Brazilian population (fasting 5.5 \u00b1 0.7 <jats:italic toggle=\"yes\">\u03bcM);<\/jats:italic> postcibal (2.4 \u00b1 0.7 <jats:italic toggle=\"yes\">\u03bcM).<\/jats:italic> After intravenous administration of [<jats:sup>3<\/jats:sup>H]bilirubin as a tracer dose or at 3.4 \u03bcmoles per kg body weight, there was delayed plasma clearance in the Bolivian monkeys. Hepatic UDP-glucuronyl transferase activity for bilirubin (164 \u00b1 25 nmoles per 30 min per gm liver) and biliary bilirubin diglucuronide to monoglucuronide ratios (2.9 \u00b1 0.2) were lower in Bolivian monkeys than in Brazilians (421 \u00b1 36 nmoles per 30 min per gm liver-p &lt; 0.01 and 4.1 \u00b1 0.1-p &lt; 0.02, respectively). Hepatic cytosol glutathione-S-transferase B activity (ligandin) levels were similar for the two populations. After phenobarbital therapy, fasting (11.1 \u00b1 0.9 <jats:italic toggle=\"yes\">\u03bcM)<\/jats:italic> and postcibal (5.3 \u00b1 1 <jats:italic toggle=\"yes\">\u03bcM)<\/jats:italic> plasma bilirubin concentrations in Bolivian monkeys were significantly reduced (p &lt; 0.001). Sulfobromophthalein clearance was slightly slower in the Bolivian than in the Brazilian monkeys. SGOT, lactate dehydrogenase, -\u03b3-glutamyl transpeptidase and alkaline phosphatase activities were not increased in Bolivians. Fasting serum conjugated bile salt concentrations in Bolivian monkeys were lower than that in Brazilian monkeys (p &lt; 0.01). Erythrocyte survival and hematological measurements were comparable in both populations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840040202","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:43:59Z","timestamp":1219412639000},"page":"175-179","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":32,"title":["A Nonhuman Primate Model of Gilbert's Syndrome"],"prefix":"10.1097","volume":"4","author":[{"given":"Oscar W.","family":"Portman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayanta Roy","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namita Roy","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles E.","family":"Cornelius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin M.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040202-BIB1","first-page":"241","article-title":"La cholemie simple familiale","volume":"21","author":"Gilbert","year":"1901","journal-title":"Semaine Med (Paris)"},{"key":"10.1002\/hep.1840040202-BIB2","first-page":"51","volume-title":"Diseases of the Liver and Biliary Tract","author":"Sherlock","year":"1976"},{"key":"10.1002\/hep.1840040202-BIB3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/imj.1967.16.3.221","article-title":"An assessment of red cell survival in idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome) by the use of radioactive diisopropylfluorophosphate and chromium","volume":"16","author":"Powell","year":"1967","journal-title":"Austr Ann Med"},{"key":"10.1002\/hep.1840040202-BIB4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1056\/NEJM197007232830403","article-title":"The reciprocal relation between caloric intake and the degree of hyperbilirubinemia in Gilbert's syndrome","volume":"283","author":"Felsher","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040202-BIB5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/bmj.3.5880.559","article-title":"Diagnosis of Gilbert's syndrome: role of reduced caloric intake test","volume":"3","author":"Owens","year":"1973","journal-title":"Br Med J"},{"key":"10.1002\/hep.1840040202-BIB6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1126\/science.126.3273.563","article-title":"Bilirubin glucuronide formation in vitro: demonstration of a defect in Gilbert's disease","volume":"126","author":"Arias","year":"1957","journal-title":"Science"},{"key":"10.1002\/hep.1840040202-BIB7","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1056\/NEJM196906052802303","article-title":"Hepatic bilirubin UDP-glucuronyl transferase activity in liver disease and Gilbert's syndrome","volume":"280","author":"Black","year":"1969","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040202-BIB8","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1172\/JCI108877","article-title":"Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert's syndrome and Crigler-Najjar syndrome","volume":"60","author":"Fevery","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840040202-BIB9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0002-9343(70)80020-1","article-title":"Constitutional hepatic dysfunction (Gilbert's syndrome): a new definition based on kinetic studies with unconjugated radiobilirubin","volume":"49","author":"Berk","year":"1970","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840040202-BIB10","first-page":"539","article-title":"An evaluation of bilirubin kinetics with respect to the diagnosis of Gilbert's syndrome","volume":"54","author":"Okolicsanyi","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"10.1002\/hep.1840040202-BIB11","doi-asserted-by":"crossref","first-page":"308","DOI":"10.7326\/0003-4819-56-2-308","article-title":"Constitutional hyperbilirubinemia with unconjugated bilirubin in the serum and lipochrome-like pigment granules in the liver","volume":"56","author":"Sagild","year":"1962","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840040202-BIB12","first-page":"41","article-title":"Excess lipofuscin accumulation in constitutional hepatic dysfunction (Gilbert's syndrome). 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An improved method utilizing delta-aminolevulinec acid-4\u221214C in dogs","volume":"68","author":"Barrett","year":"1966","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840040202-BIB24","first-page":"499","article-title":"Preparation and properties of specifically labeled radiochemically stable 3H-bilirubin","volume":"75","author":"Howe","year":"1970","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840040202-BIB25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.1840010610","article-title":"Bilirubin mono- and diglucuronide formation by human liver in vitro: Assay by high pressure liquid chromatography","volume":"1","author":"Roy Chowdhury","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840040202-BIB26","unstructured":"Technicon Technical Bulletins: SMA-C methods no. SG 4-0010J-81; SG 4-0021-81; SG 4-0006J-81, 1981."},{"key":"10.1002\/hep.1840040202-BIB27","unstructured":"Technicon Technical Bulletin: SMA-C method no. 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