{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:01:21Z","timestamp":1792839681005,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11506,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>In this study, we describe a radioimmunoassay to detect liver membrane binding antibodies. The assay was designed to exclude binding of aggregated IgG or immune complexes to Fc 7 receptors of hepatocytes. When this assay was applied to sera from 142 patients, antibodies were found in highest titer in patients with autoimmune chronic active hepatitis, rarely in patients with hepatitis B virus-induced chronic active liver disease, and in 32% of patients with primary biliary cirrhosis. IgM antibodies were found in 100% of patients with acute Type A but not B or non-A, non-B hepatitis. IgA class antibodies were found in the sera of 57% of patients with alcohol-induced hepatitis. All patient groups showing significant titers of liver membrane antibodies display the lesion of piecemeal necrosis except those with alcohol-induced hepatitis. Further studies are needed to determine whether this antibody is the cause of the lesion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840040206","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:43:59Z","timestamp":1219412639000},"page":"199-204","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":43,"title":["Liver Membrane Antibodies Detected by Immunoradiometric Assay in Acute and Chronic Virus-Induced and Autoimmune Liver Disease"],"prefix":"10.1097","volume":"4","author":[{"given":"K. H.","family":"Wiedmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. C.","family":"Bartholemew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J. C.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard C.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040206-BIB1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1056\/NEJM197603112941103","article-title":"Detection of a liver membrane auto antibody in HBsAg-negative chronic active hepatitis","volume":"294","author":"Hopf","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040206-BIB2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02054104","article-title":"Introduction","volume":"3","author":"Thomas","year":"1980","journal-title":"Springer Semin Immunopathol"},{"key":"10.1002\/hep.1840040206-BIB3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02054109","article-title":"Clinical, histological and immunopathological features of primary biliary cirrhosis","volume":"3","author":"Popper","year":"1980","journal-title":"Springer Semin Immunopathol"},{"key":"10.1002\/hep.1840040206-BIB4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-0676.1982.tb00178.x","article-title":"The pathology of hepatitis A in man","volume":"2","author":"Teixeira","year":"1982","journal-title":"Liver"},{"key":"10.1002\/hep.1840040206-BIB5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197807062990101","article-title":"Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis","volume":"299","author":"Jensen","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040206-BIB6","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/gut.21.11.955","article-title":"Auto-antibodies against liver-specific membrane lipoprotein in acute and chronic liver diseases: studies on organ-, species-, and disease-specificity","volume":"21","author":"Manns","year":"1980","journal-title":"Gut"},{"key":"10.1002\/hep.1840040206-BIB7","first-page":"381","article-title":"Purification and characterization of human liver-specific membrane lipoprotein (LSP)","volume":"27","author":"McFarlane","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840040206-BIB8","first-page":"89","article-title":"Liver specific antigens, purification and characterization","volume":"10","author":"Meyer zum B\u00fcschenfelde","year":"1972","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840040206-BIB9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.4049\/jimmunol.117.2.639","article-title":"Demonstration of binding sites for IgG Fc and the third complement component (C3) on isolated hepatocytes","volume":"2","author":"Hopf","year":"1976","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840040206-BIB10","volume-title":"Liver biopsy interpretation","author":"Scheuer","year":"1980"},{"key":"10.1002\/hep.1840040206-BIB11","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1083\/jcb.43.3.506","article-title":"High yield preparation of isolated rat liver parenchymal cells. A biochemical and fine stuctural study","volume":"43","author":"Berry","year":"1969","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840040206-BIB12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-679X(08)61797-5","article-title":"Preparation of isolated rat liver cells","volume":"13","author":"Seglen","year":"1976","journal-title":"Methods Cell Biol"},{"key":"10.1002\/hep.1840040206-BIB13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0016-5085(81)90712-5","article-title":"HBsAg-associated albumin receptors and anti-albumin antibodies in sera of patients with liver disease","volume":"80","author":"Thung","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040206-BIB14","first-page":"266","article-title":"Anti-actin specificity of human smooth muscle antibodies in chronic active hepatitis","volume":"24","author":"Lidman","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840040206-BIB15","volume-title":"Manuel des techniques immunologiques","author":"Roitt","year":"1966"},{"key":"10.1002\/hep.1840040206-BIB16","first-page":"349","article-title":"Monoclonal antibodies in a solid phase radiometric assay for HBs antigen","volume":"38","author":"Goodall","year":"1981","journal-title":"Med Lab Sci"},{"key":"10.1002\/hep.1840040206-BIB17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/bmj.1.6055.206","article-title":"Liver membrane autoantibody specific for inflammatory liver disease","volume":"1","author":"Tage-Jensen","year":"1977","journal-title":"Br Med J"},{"key":"10.1002\/hep.1840040206-BIB18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000198726","article-title":"Clinical evaluation of the liver cell membrane autoantibody assay","volume":"23","author":"Schuurman","year":"1982","journal-title":"Digestion"},{"key":"10.1002\/hep.1840040206-BIB19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF02054106","article-title":"The role of liver membrane antigens as targets in autoimmune type liver disease","volume":"3","author":"Meyer zum B\u00fcschenfelde","year":"1980","journal-title":"Springer Semin Immunopathol"},{"key":"10.1002\/hep.1840040206-BIB20","first-page":"1388","article-title":"Natural history of hepatitis-associated antigen positive chronic liver disease","volume":"2","author":"Dudley","year":"1982","journal-title":"Lancet"},{"key":"10.1002\/hep.1840040206-BIB21","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.150.6.1577","article-title":"Secretory components as the receptor for polymeric IgA on rat hepatocytes","volume":"150","author":"Orlans","year":"1979","journal-title":"J Exp Med"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198403000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:09:37Z","timestamp":1733051377000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198403000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040206","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}