{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:27:27Z","timestamp":1791847647203,"version":"4.3.4"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11506,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,3]]},"abstract":"\n \n The hepatorenal syndrome, a primary cause of death from acute and chronic liver disease, consists of a functional renal failure whereby examination of the kidney has previously shown no distinct or specific morphologic change. We describe an unusual renal lesion consisting of the reflux of proximal convoluted tubular epithelium into Bowman's space. An autopsy series shows this glomerular change to be present in 71.4% of cases with the hepatorenal syndrome, while only present in 0 to 27.3% in other autopsy categories (p < 0.001). Since this lesion has been previously described with experimental renal ischemic change and terminal hypotension, it is possible that it is caused in part by the decreased or altered renal blood flow known to be associated with the hepatorenal syndrome.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840040212","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:43:59Z","timestamp":1219412639000},"page":"242-246","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":29,"title":["Glomerular Tubular Reflux-A Morphologic Renal Lesion Associated with the Hepatorenal Syndrome"],"prefix":"10.1097","volume":"4","author":[{"given":"Gary C.","family":"Kanel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040212-BIB1","first-page":"847","volume-title":"Diseases of the liver","author":"Conn","year":"1982"},{"key":"10.1002\/hep.1840040212-BIB2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.7326\/0003-4819-60-3-366","article-title":"The kidney in cirrhosis. II. Disorders of renal function","volume":"60","author":"Baldus","year":"1964","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840040212-BIB3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0002-9343(67)90247-1","article-title":"Renal failure in patients with cirrhosis of the liver. III. Evaluation of intrarenal blood flow by para-aminohippurate extraction and response to angiotensin","volume":"43","author":"Schroeder","year":"1967","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840040212-BIB4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/path.1700060405","article-title":"The development of the Malpighian bodies of the kidney and its relationship to pathologic changes which occur in them","volume":"6","author":"Herring","year":"1900","journal-title":"J Pathol Bact"},{"key":"10.1002\/hep.1840040212-BIB5","first-page":"93","article-title":"Infraglomerular epithelial reflux. An early lesion of acute renal failure","volume":"77","author":"Waugh","year":"1964","journal-title":"Arch Pathol"},{"key":"10.1002\/hep.1840040212-BIB6","first-page":"171","article-title":"An experimental study of glomerulonephritis","volume":"1","author":"Welch","year":"1886","journal-title":"Trans Assoc Amer Physicians"},{"key":"10.1002\/hep.1840040212-BIB7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1177\/5.3.204","article-title":"A comparative study of enzymatic staining reactions in the rat kidney with necrobiosis induced by ischemia and nephrotoxic agents (Mercuhydrin and DL-Serin)","volume":"5","author":"Wachstein","year":"1957","journal-title":"J Histochem Cytochem"},{"key":"10.1002\/hep.1840040212-BIB8","first-page":"547","article-title":"Infraglomerular epithelial reflux in the evolution of serotonin nephropathy in rats","volume":"39","author":"Waugh","year":"1961","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840040212-BIB9","first-page":"781","volume-title":"Pathology of the kidney","author":"Heptinstall","year":"1974"},{"key":"10.1002\/hep.1840040212-BIB10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/path.1700680243","article-title":"The occurrence of columnar epithelium in Bowman's capsule","volume":"68","author":"Finckh","year":"1954","journal-title":"J Pathol Bact"},{"key":"10.1002\/hep.1840040212-BIB11","first-page":"265","article-title":"The relationship between the clinical and the histological features of acute glomerular nephritis: based on a study of renal biopsy material","volume":"27","author":"Hutt","year":"1958","journal-title":"Q J Med"},{"key":"10.1002\/hep.1840040212-BIB12","first-page":"755","article-title":"Histologic aspects of subacute glomerulonephritis; with special reference to proliferative alterations in the epithelium of renal tubules","volume":"35","author":"Garcia-Caceres","year":"1959","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840040212-BIB13","volume-title":"Pathology of the kidney","author":"Heptinstall","year":"1974"},{"key":"10.1002\/hep.1840040212-BIB14","volume-title":"Statistics in medicine","author":"Colton","year":"1974"},{"key":"10.1002\/hep.1840040212-BIB15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0002-9343(70)80073-0","article-title":"Renal failure in the patient with cirrhosis: The role of active vasoconstriction","volume":"49","author":"Epstein","year":"1970","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840040212-BIB16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0140-6736(71)90435-1","article-title":"Renal and intrarenal blood-flow in cirrhosis of the liver","volume":"2","author":"Kew","year":"1971","journal-title":"Lancet"},{"key":"10.1002\/hep.1840040212-BIB17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jcp.31.2.101","article-title":"Spectrum of renal tubular damage in renal failure secondary to cirrhosis and fulminant hepatic failure","volume":"31","author":"Wilkinson","year":"1978","journal-title":"J Clin Pathol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198403000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:09:32Z","timestamp":1733051372000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198403000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040212","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}