{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:00:06Z","timestamp":1761217206463,"version":"3.30.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11506,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>In alcohol-induced liver injury, hyperprolinemia has been proposed as a marker of fibrogenesis probably secondary to hyperlactacidemia. However, some studies of plasma proline in alcoholics with cirrhosis have reported normal rather than increased levels. In order to evaluate the frequency of hyperprolinemia in alcoholic liver disease and its relationship to blood lactate, we measured plasma proline levels in 145 subjects including 91 alcoholics with a spectrum of liver disease as well as 22 nonalcoholics with liver injury unrelated to alcohol. We also studied baboons fed alcohol as 50% of total calories for 1 to 4 years. Among alcoholics only 21\/91 had elevated proline values. Elevations were most frequent among patients with severe hepatic decompensation (3\/8), in patients with alcoholic hepatitis on liver biopsy (5\/17), and in those with acute alcohol-related withdrawal, with alcohol still present in the blood (4\/9). Patients with liver disease unrelated to alcohol but severe in nature also has elevations in proline (3\/3). Only 4\/28 patients with cirrhosis due to alcohol had elevated values, and none of the baboons fed alcohol had hyperprolinemia whether withdrawn from alcohol or not. Hyperlactacidemia was associated with hyperprolinemia, but so were depressed serum albumin values and prolongations of the prothrombin time, suggesting a general association with severe liver disease. These results reveal that hyperprolinemia occurs infrequently in patients with alcohol-induced cirrhosis and therefore does not appear to be a sensitive marker of hepatic fibrosis in these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840040220","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:43:59Z","timestamp":1219412639000},"page":"295-299","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":20,"title":["Frequency of Hyperprolinemia in Alcoholic Liver Cirrhosis: Relationship to Blood Lactate"],"prefix":"10.1097","volume":"4","author":[{"given":"Spencer","family":"Shaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa M.","family":"Worner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Lieber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040220-BIB1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0016-5085(75)80243-5","article-title":"Serum free proline in patients with chronic liver disease","volume":"68","author":"Mata","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040220-BIB2","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/0016-5085(81)90074-3","article-title":"Relationship between blood lactic acid and serum proline in alcoholic liver cirrhosis","volume":"80","author":"Kershenobich","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040220-BIB3","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1172\/JCI106443","article-title":"The relationship between the free pool of proline and collagen content in human liver cirrhosis","volume":"49","author":"Kershenobich","year":"1970","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840040220-BIB4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/00365528009181486","article-title":"Influence of extracellular proline on collagen synthesis in rat liver slices","volume":"15","author":"Tyopponen","year":"1980","journal-title":"Scand J Gastroenterol"},{"key":"10.1002\/hep.1840040220-BIB5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0016-5085(77)80261-8","article-title":"Plasma amino acid patterns in hepatic encephalopathy of differing etiology","volume":"72","author":"Rosen","year":"1977","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040220-BIB6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00000658-197911000-00004","article-title":"Proline metabolism in sepsis, cirrhosis and general surgery. The peripheral energy deficit","volume":"190","author":"Cerra","year":"1979","journal-title":"Ann Surg"},{"key":"10.1002\/hep.1840040220-BIB7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0002-9343(72)90038-1","article-title":"Amino acid metabolism in lactic acidosis","volume":"54","author":"Marliss","year":"1972","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840040220-BIB8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF02232835","article-title":"Plasma and urinary amino acids in Laennec's cirrhosis","volume":"14","author":"Zinneman","year":"1969","journal-title":"Am J Dig Dis"},{"key":"10.1002\/hep.1840040220-BIB9","first-page":"386","article-title":"Hyperglucagonemia in Laennec's cirrhosis","volume":"292","author":"Sherwin","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040220-BIB10","first-page":"417","article-title":"Plasma amino acids in patients with liver failure","volume":"50","author":"Iber","year":"1957","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840040220-BIB11","first-page":"191","article-title":"Konzentrationen von Aminosauren im Blut verschiedener Gefassabschnitte von Patienten mit Lebercirrhose wahrend und nach Anlegen einer porto-cavalen Anastomose","volume":"13","author":"Breuer","year":"1975","journal-title":"Z Klin Chem Biochem"},{"key":"10.1002\/hep.1840040220-BIB12","first-page":"554","article-title":"Serum amino acid concentrations in alcoholic hepatitis","volume":"70","author":"Ning","year":"1967","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840040220-BIB13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0954-6820.1968.tb10454.x","article-title":"Plasma amino acids in prepsychotic alcoholics","volume":"183","author":"Frederiksen","year":"1968","journal-title":"Acta Med Scand"},{"key":"10.1002\/hep.1840040220-BIB14","first-page":"1232","article-title":"Animal models of ethanol dependence and liver injury in rats and baboons","volume":"35","author":"Lieber","year":"1976","journal-title":"Fed Proc"},{"key":"10.1002\/hep.1840040220-BIB15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0016-5085(78)90243-3","article-title":"Plasma amino acid abnormalities in the alcoholic; respective role of alcohol, nutrition and liver injury","volume":"74","author":"Shaw","year":"1978","journal-title":"Gastroenterology"},{"volume-title":"The Model 121M Microcolumn Amino Acid Analyzer Instruction Manual","year":"1976","key":"10.1002\/hep.1840040220-BIB16","unstructured":"The Model 121M Microcolumn Amino Acid Analyzer Instruction Manual. Palo Alto, Calif.: Spinco Division, Beckman Instruments, Inc., July, 1976."},{"volume-title":"The quantitative determination of pyruvic acid and lactic acid","year":"1976","author":"Sigma Technical Bulletin No. 726 UV\/826 UV","key":"10.1002\/hep.1840040220-BIB17"},{"key":"10.1002\/hep.1840040220-BIB18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1056\/NEJM197502202920802","article-title":"High blood acetal-dehyde levels after ethanol administration: difference between alcoholic and non-alcoholic subjects","volume":"292","author":"Korsten","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040220-BIB19","first-page":"695","article-title":"Histogenesis of alcoholic fibrosis and cirrhosis in the baboon","volume":"98","author":"Popper","year":"1980","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840040220-BIB20","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0016-5085(82)80006-1","article-title":"Perivenular fibrosis in alcoholic liver injury: ultrastructure and histologic progression","volume":"83","author":"Nakano","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040220-BIB21","first-page":"6","article-title":"A high hepatic concentration of free proline does not induce collagen synthesis in rat liver","volume":"30","author":"Forsander","year":"1983","journal-title":"Hepato-Gastroenterol"},{"key":"10.1002\/hep.1840040220-BIB22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1126\/science.176.4036.795","article-title":"Hepatic collagen metabolism: effect of alcohol consumption in rats and baboons","volume":"176","author":"Feinman","year":"1972","journal-title":"Science"},{"key":"10.1002\/hep.1840040220-BIB23","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1172\/JCI104643","article-title":"Interrelations of uric acid and ethanol metabolism in man","volume":"41","author":"Lieber","year":"1962","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840040220-BIB24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0026-0495(73)90068-1","article-title":"A study of plasma free amino acid levels. 1. Study of factors affecting validity of amino acid analysis","volume":"22","author":"Armstrong","year":"1973","journal-title":"Metabolism"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040220","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198403000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:08:46Z","timestamp":1733051326000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198403000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040220","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}