{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:31:03Z","timestamp":1778567463388,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11445,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The present trial compared the effectiveness and complications of intravenous somatostatin and vasopressin in treatment of variceal bleeding. Sixty-one cirrhotic patients with endoscopically proven active variceal bleeding were included. Both drugs were given as continuous intravenous infusions for 48 hr. Thirty patients received somatostatin (250 #ig per hr after a bolus of 50 ng) and 31 vasopressin (0.4 units per min).<\/jats:p>\n            <jats:p>Initial control of bleeding was achieved in 26 (87%) patients receiving somatostatin and in 23 (74%) of those treated with vasopressin.<\/jats:p>\n            <jats:p>However, 10 patients [not significant statistically] in the somatostatin group and 5 in the vasopressin group rebled during treatment, after a mean of 15 and 20 hr, respectively. Therefore, complete control of bleeding during the 48 hr of therapy was achieved in 16 (53%) patients treated with somatostatin and in 18 (58%) of those receiving vasopressin. Mortality during hospitalization was similar in both groups (somatostatin 47%, vasopressin 45%).<\/jats:p>\n            <jats:p>Differences were observed in complications associated with each therapy. Vasopressin produced major complications in 8 patients (left ventricular failure in 4 and severe abdominal pain requiring drug withdrawal in 4), and minor complications in 14; somatostatin infusion produced minor complications in 3 patients (p &lt; 0.01). In addition, the serum sodium concentration was significantly reduced by vasopressin (from 134.3 \u00b1 1.6 to 128.3 \u00b1 1.4 mEq per liter, p &lt; 0.001) but not by somatostatin (134.6 \u00b1 1.1 vs. 133.2 \u00b1 1.1 mEq per liter).<\/jats:p>\n            <jats:p>This study shows that somatostatin is as effective as vasopressin in controlling variceal hemorrhage, but has a much lower rate of complications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840040315","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:28:13Z","timestamp":1219411693000},"page":"442-446","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":196,"title":["Comparison of Intravenous Somatostatin and Vasopressin Infusions in Treatment of Acute Variceal Hemorrhage\u2020"],"prefix":"10.1097","volume":"4","author":[{"given":"David","family":"Kravetz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Ter\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Bruix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Rimola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Rod\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040315-BIB1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0140-6736(60)91423-9","article-title":"The use of vasopressin (pitressin) in the control of bleeding from esophageal varices","volume":"2","author":"Shaldon","year":"1960","journal-title":"Lancet"},{"key":"10.1002\/hep.1840040315-BIB2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1056\/NEJM196201182660307","article-title":"Effect of intravenously administered posterior pituitary extract of hemorrhage from bleeding esophageal varices. A controlled evaluation","volume":"266","author":"Merigan","year":"1962","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040315-BIB3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0016-5085(75)80001-1","article-title":"Intraarterial vasopressin in the treatment of upper gastrointestinal hemorrhage: a prospective controlled clinical trial","volume":"68","author":"Conn","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040315-BIB4","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0016-5085(79)90020-9","article-title":"A controlled comparison of continuous intraarterial and intravenous infusions of vasopressin in hemorrhage from esophageal varices","volume":"77","author":"Chojkier","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040315-BIB5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00000658-197709000-00015","article-title":"Control of bleeding varices by vasopressin: A prospective randomized study","volume":"186","author":"Johnson","year":"1977","journal-title":"Ann Surg"},{"key":"10.1002\/hep.1840040315-BIB6","first-page":"539","article-title":"Traitment par la pitresine des h\u00e9morragies par rupture de varices oesophagiennes chez le cirrhotique. 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Comparison with vasopressin","volume":"80","author":"Bosch","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040315-BIB10","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/hep.1840020602","article-title":"Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension","volume":"2","author":"Groszmann","year":"1982","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840040315-BIB11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/01.CIR.24.4.797","article-title":"Effect of pitressin on the splanchnic circulation in man","volume":"24","author":"Shaldon","year":"1961","journal-title":"Circulation"},{"key":"10.1002\/hep.1840040315-BIB12","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00000658-197903000-00007","article-title":"Selective intra-arterial vaso-pressin-clinical efficacy and complications","volume":"189","author":"Sherman","year":"1979","journal-title":"Ann 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