{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:04:15Z","timestamp":1793703855722,"version":"4.5.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11384,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Primary biliary cirrhosis is infrequently diagnosed in men, so that the clinical, biochemical and histopathological spectrum of this disease in men has not been evaluated. Therefore, we studied 30 men who had a histological diagnosis of primary biliary cirrhosis and had positive tests for antimitochondrial antibodies. Five patients had no hepatobiliary symptoms, and two of these patients had neither biochemical nor histological evidence of cholestasis. These 30 male patients\u2019 findings were compared with the findings in 30 age-matched women who also had primary biliary cirrhosis and antimitochondrial antibodies. Six of these patients were asymptomatic. Clinical findings and symptomatic status, in addition to biochemical and histopathological features, were generally similar in both male and female patients. The possible significance of higher serum alkaline phosphatase activities and lower frequency of occurrence of piecemeal necrosis in men with primary biliary cirrhosis, as compared with women, requires further study.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840040418","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:24:44Z","timestamp":1219411484000},"page":"671-677","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":31,"title":["Does Primary Biliary Cirrhosis in Men Differ from Primary Biliary Cirrhosis in Women?\u2020 \u2021 \u00a7"],"prefix":"10.1097","volume":"4","author":[{"given":"Lawrence R.","family":"Rubel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Rabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Seeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Licht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda A.","family":"Cuccherini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040418-BIB1","first-page":"1278","article-title":"Primary biliary cirrhosis-a revised clinical spectrum","volume":"1","author":"James","year":"1981","journal-title":"Lancet"},{"key":"10.1002\/hep.1840040418-BIB2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1055\/s-2008-1040731","article-title":"The natural history of primary biliary cirrhosis","volume":"1","author":"Kapelman","year":"1981","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840040418-BIB3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/0003-4819-77-4-533","article-title":"Mitochondrial antibody in primary biliary cirrhosis and other diseases","volume":"77","author":"Klatskin","year":"1972","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840040418-BIB4","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM197309272891306","article-title":"The presentation and diagnosis of 100 patients with primary biliary cirrhosis","volume":"289","author":"Sherlock","year":"1973","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040418-BIB5","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/bmj.281.6243.772","article-title":"Primary biliary cirrhosis: an epidemiological study","volume":"281","author":"Triger","year":"1980","journal-title":"Br Med J"},{"key":"10.1002\/hep.1840040418-BIB6","first-page":"370","article-title":"Studies on the pathogenesis of hepatolenticular degeneration. 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Cytochemical methods for the localization of copper","volume":"87","author":"Lindquist","year":"1969","journal-title":"Arch Pathol"},{"key":"10.1002\/hep.1840040418-BIB7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/ajcp\/42.3.259","article-title":"The pathology of primary biliary cirrhosis with emphasis on histogenesis","volume":"42","author":"Baggenstoss","year":"1964","journal-title":"Am J Clin Pathol"},{"key":"10.1002\/hep.1840040418-BIB8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis","volume":"1","author":"Knodell","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840040418-BIB9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00000441-198201000-00007","article-title":"Fatal methyldopa-associated granulomatous hepatitis and myocarditis","volume":"283","author":"Bezahler","year":"1982","journal-title":"Am J Med Sci"},{"key":"10.1002\/hep.1840040418-BIB10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/hep.1840010311","article-title":"Phenylbutazone liver injury: a clinic\u03b11-pathological survey of 23 cases and review of the literature","volume":"1","author":"Benjamin","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840040418-BIB11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0016-5085(76)80248-X","article-title":"Quinidine hypersensitivity and liver involvement","volume":"70","author":"Geltner","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040418-BIB12","first-page":"61","article-title":"Drug-induced granulomatous hepatitis","volume":"44","author":"McMaster","year":"1981","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840040418-BIB13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0046-8177(80)80026-8","article-title":"Iatrogenic hepatic injury","volume":"11","author":"Rubin","year":"1980","journal-title":"Human Pathol"},{"key":"10.1002\/hep.1840040418-BIB14","first-page":"349","volume-title":"Hepatotoxicity","author":"Zimmerman","year":"1978"},{"key":"10.1002\/hep.1840040418-BIB15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1055\/s-2008-1040732","article-title":"Histopathology of primary biliary cirrhosis","volume":"1","author":"MacSween","year":"1981","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840040418-BIB16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/gut.22.2.136","article-title":"Is mitochondrial antibody diagnostic of primary biliary cirrhosis?","volume":"22","author":"Munoz","year":"1981","journal-title":"Gut"},{"key":"10.1002\/hep.1840040418-BIB17","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/gut.21.10.870","article-title":"Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology","volume":"21","author":"Chapman","year":"1980","journal-title":"Gut"},{"key":"10.1002\/hep.1840040418-BIB18","first-page":"365","article-title":"Autoimmune associations in primary biliary cirrhosis","volume":"57","author":"Culp","year":"1982","journal-title":"Mayo Clin Proc"},{"key":"10.1002\/hep.1840040418-BIB19","first-page":"194","article-title":"Chronic cholestasis following prolonged tolbutamide administration","volume":"84","author":"Gregory","year":"1967","journal-title":"Arch Pathol"},{"key":"10.1002\/hep.1840040418-BIB20","first-page":"283","article-title":"Hepatic injury associated with the phenothia-zines","volume":"93","author":"Ishak","year":"1972","journal-title":"Arch Pathol"},{"key":"10.1002\/hep.1840040418-BIB21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0002-9343(59)90188-3","article-title":"Liver cell necrosis in chlorpromazine jaundice (allergic cholangiolitis)","volume":"27","author":"Zelman","year":"1959","journal-title":"Am J Med"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040418","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198407000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:02:25Z","timestamp":1733050945000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198407000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040418","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1984,7]]}}}