{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:09:46Z","timestamp":1786118986686,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11322,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      To evaluate the diagnostic and prognostic significance of the\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      -terminal propeptide of collagen Type III (Col 1-3) in chronic liver disease, the peptide level was measured in the serum of 4 patients with primary biliary cirrhosis, 5 with chronic persistent hepatitis, 12 with chronic active hepatitis, and 1 with autoimmune hepatitis, for a period of 2 to 10 years and compared with liver function and histology. In primary biliary cirrhosis, Col 1-3 peptide levels were always elevated, regardless of medical therapy; however, after liver transplantation in one patient, the Col 1-3 peptide level decreased. In chronic persistent hepatitis, the peptide level fluctuated around the upper limit of normal. Among patients with chronic active hepatitis, the Col 1-3 peptide level normalized in 2 patients during remission, but was elevated in 7 patients who developed cirrhosis. Only in a patient with autoimmune hepatitis was the Col 1-3 peptide level normal, although the patient developed cirrhosis during prednisone therapy. When prednisone was withdrawn, the Col 1-3 peptide level increased. The data suggest that the serum Col 1-3 peptide may estimate the course of liver fibrosis in chronic liver disease and has prognostic value, particularly in chronic active hepatitis. Persistent elevation suggests ongoing fibrosis and development of cirrhosis; normalization suggests remission.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.1840040506","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T09:06:35Z","timestamp":1219395995000},"page":"835-838","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":70,"title":["Long-Term Follow-Up of Serum N-Terminal Propeptide of Collagen Type III Levels in Patients with Chronic Liver Disease\u2020"],"prefix":"10.1097","volume":"4","author":[{"given":"Kurt","family":"Weigand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Zaugg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Frei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040506-BIB1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2362.1979.tb00912.x","article-title":"Radioimmunoassay for type III procollagen peptide and its application to human liver disease","volume":"9","author":"Rohde","year":"1979","journal-title":"Eur J Clin Invest"},{"key":"10.1002\/hep.1840040506-BIB2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/hep.1840040505","article-title":"The JV-terminal propeptide of collagen type III in serum reflects activity and degree of fibrosis in patients with chronic liver disease","volume":"4","author":"Frei","year":"1984","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840040506-BIB3","first-page":"118","article-title":"Determination of the hepatic elimination capacity (Lm) of galactose by single injection","volume":"92","author":"Tygstrup","year":"1966","journal-title":"Scand J Clin Invest"},{"key":"10.1002\/hep.1840040506-BIB4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM198201073060101","article-title":"Recurrence of primary biliary cirrhosis after liver transplantation","volume":"306","author":"Neuberger","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040506-BIB5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0016-5085(83)90308-6","article-title":"Aminoterminal propeptide of type III procollagen in serum in alcoholic liver disease","volume":"85","author":"Niemel\u00e4","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040506-BIB6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0016-5085(79)80170-5","article-title":"Collagen types in normal and cirrhotic liver","volume":"76","author":"Rojkind","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040506-BIB7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1073\/pnas.73.2.539","article-title":"Increase in type I and type III collagens in human alcoholic liver cirrhosis","volume":"73","author":"Rojkind","year":"1976","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/01515467-198409000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:14:24Z","timestamp":1786036464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01515467-198409000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040506","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}