{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:38:37Z","timestamp":1760204317421,"version":"3.30.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11261,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,11]]},"abstract":"\n \n Antibodies reacting in immunofluorescence with the basal cell layer of rat forestomach (BCLA) have been detected in 36 of 121 (30%) hepatitis B virus (HBV)-mediated chronic liver disease (CLD), in 1 of 30 (3%) HBV-negative CLD, in 3 of 36 (8%) alcoholic liver disease (with no correlation with serum HBV markers), in 1 of 25 (4%) primary biliary cirrhosis, in none of 19 HBV-related HBsAg-negative CLD and 60 healthy blood donors. Of 352 hospitalized patients with miscellaneous diseases (including immunological conditions), the antibodies were found in four (1%).<\/jats:p>\n In the 36 BCLA positive cases from HBV-mediated CLD, evidence of chronic delta infection was found in 34. The overall prevalence of BCLA in 68 delta cases was 50% (58% in chronic active hepatitis, 46% in cirrhosis), and in 28 delta negative cases was 4% (p < 0.00002).<\/jats:p>\n BCLA of delta cases were mainly of the IgG class (38 of 41 sera), and high titers (up to 40,960) were found in the majority (66% >1:640).<\/jats:p>\n The high titer BCLA has to be considered a marker of chronic delta infection in HBV cases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840040601","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:39:01Z","timestamp":1219412341000},"page":"1103-1106","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Close Association Between Basal Cell Layer Antibodies and Hepatitis B Virus-Associated Chronic Delta Infection"],"prefix":"10.1097","volume":"4","author":[{"given":"Daniela","family":"Zauli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Fusconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Crespi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco B.","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Craxi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Pisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040601-BIB1","first-page":"183","article-title":"Incidence of circulating antibodies reactive with basal cells of skin in drug reactions","volume":"54","author":"Van Joost","year":"1974","journal-title":"Acta Dermatovener (Stockholm)"},{"key":"10.1002\/hep.1840040601-BIB2","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1001\/archderm.1977.01640100058008","article-title":"Clinical significance of basal cell layer antibodies","volume":"113","author":"Bystryn","year":"1977","journal-title":"Arch Dermatol"},{"key":"10.1002\/hep.1840040601-BIB3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0090-1229(83)90129-0","article-title":"Autoantibodies against the basal cell layer: an association with chronic hepatitis B","volume":"26","author":"Lenkei","year":"1983","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1002\/hep.1840040601-BIB4","first-page":"232","article-title":"Microsomal autoantibodies in chronic infection with the HBsAg associated delta agent","volume":"54","author":"Crivelli","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840040601-BIB5","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0140-6736(79)92561-3","article-title":"Incidence and significance of antibodies to delta antigen in hepatitis B virus infection","volume":"2","author":"Rizzetto","year":"1979","journal-title":"Lancet"},{"key":"10.1002\/hep.1840040601-BIB6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/gut.18.12.997","article-title":"Immunofluorescence detection of a new antigen\/antibody system (delta\/anti-delta) associated with hepatitis B virus in liver and serum of HBsAg carriers","volume":"18","author":"Rizzetto","year":"1977","journal-title":"Gut"},{"key":"10.1002\/hep.1840040601-BIB7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.1840030304","article-title":"Cytoskeleton antibodies in chronic active hepatitis, primary biliary cirrhosis and alcoholic liver disease","volume":"3","author":"Kurki","year":"1983","journal-title":"Hepatology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040601","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198411000-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:10:13Z","timestamp":1733051413000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198411000-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040601","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}