{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:12:51Z","timestamp":1778638371076,"version":"3.51.4"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11261,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,11]]},"abstract":"\n \n The nicotinic acid test was performed in 5 patients with Dubin-Johnson syndrome, 5 with Rotor syndrome and 13 with Gilbert\u2019s syndrome. The increment in serum bilirubin concentration and bilirubin retention 5 hr later differed; the proportion of conjugated bilirubin in the increment of total bilirubin in Dubin-Johnson and Rotor syndromes was greater than in Gilbert\u2019s syndrome. These observations suggest that the nicotinic acid test reflects, in part, impaired biliary excretion of conjugated bilirubin. The results did not differentiate the two conjugated hyperbilirubinemias. The nicotinic acid test was also performed before and after corticosteroid treatment in four patients with Dubin-Johnson or Rotor syndrome. Although serum total and unconjugated bilirubin concentrations were reduced by corticosteroids, no significant change occurred in the parameters of the nicotinic acid test, suggesting that corticosteroids may enhance uptake of bilirubin without significantly altering biliary excretion of conjugated bilirubin.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840040618","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:39:01Z","timestamp":1219412341000},"page":"1206-1208","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["The Nicotinic Acid Test in Constitutional Conjugated Hyperbilirubinemias and Effects of Corticosteroid"],"prefix":"10.1097","volume":"4","author":[{"given":"Hideki","family":"Ohkubo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040618-BIB1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00005792-197211000-00002","article-title":"Constitutional hepatic dysfunction (CHD): a review with special reference to a characteristic increase and prolongation of the hyperbilirubinemic response to nicotinic acid","volume":"51","author":"Fromke","year":"1972","journal-title":"Medicine"},{"key":"10.1002\/hep.1840040618-BIB2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/BF01314468","article-title":"Studies on nicotinic acid interaction with bilirubin metabolism","volume":"24","author":"Ohkubo","year":"1979","journal-title":"Dig Dis Sci"},{"key":"10.1002\/hep.1840040618-BIB3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1136\/gut.22.8.663","article-title":"Nicotinic acid test in the diagnosis of Gilbert's syndrome: correlation with bilirubin clearance","volume":"22","author":"Rollinghoff","year":"1981","journal-title":"Gut"},{"key":"10.1002\/hep.1840040618-BIB4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00005792-195902000-00002","article-title":"Constitutional hepatic dysfunction (Gilbert's syndrome): its natural history and related syndrome","volume":"38","author":"Foulk","year":"1959","journal-title":"Medicine (Baltimore)"},{"key":"10.1002\/hep.1840040618-BIB5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005792-195409000-00001","article-title":"Chronic idiopathic jaundice with unidentified pigment in liver cells: new clinicopathologic entity with report of 12 cases","volume":"33","author":"Dubin","year":"1954","journal-title":"Medicine (Baltimore)"},{"key":"10.1002\/hep.1840040618-BIB6","first-page":"549","article-title":"Dubin-Johnson syndrome is Israel. I. Clinical, Laboratory, and genetic asspects of 101 cases","volume":"39","author":"Shani","year":"1970","journal-title":"Q J Med"},{"key":"10.1002\/hep.1840040618-BIB7","first-page":"57","article-title":"Familial non-hemolytic jaundice with direct van den Bergh reaction","volume":"5","author":"Rotor","year":"1948","journal-title":"Acta Med Philipina"},{"key":"10.1002\/hep.1840040618-BIB8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0002-9343(76)90426-5","article-title":"Rotor's syndrome, a distinct inheritable pathophysiologic entity","volume":"60","author":"Wolkoff","year":"1976","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840040618-BIB9","first-page":"1","article-title":"Bilirubin determination in serum and urine","volume":"5","author":"Mich\u00e4elsson","year":"1961","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1002\/hep.1840040618-BIB10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/hep.1840010213","article-title":"Effects of corticosteroids on bilirubin metabolism in patients with Gilbert's syndrome","volume":"2","author":"Ohkubo","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840040618-BIB11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0016-5085(81)90662-4","article-title":"Ursodeoxycholic acid oral tolerance test in patients with constitutional hyperbilirubinemias and effects of phenobarbital","volume":"81","author":"Ohkubo","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840040618-BIB12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000197719","article-title":"Biliary excretion of conjugated sulfobromophthalein (BSP) in constitutional conjugated hyperbilirubinemias","volume":"13","author":"Abe","year":"1975","journal-title":"Digestion"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040618","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198411000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:08:41Z","timestamp":1733051321000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198411000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040618","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}