{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:15:08Z","timestamp":1774012508847,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11200,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>A controlled randomized study was performed in 15 patients with biopsy\u2013proven alcoholic hepatitis to determine the effect of the administration of a parenteral amino acid\u2013glucose solution for 1 month on nutritional, clinical, biochemical and histological parameters. All patients were allowed <jats:italic toggle=\"yes\">ad libitum<\/jats:italic> consumption of a hospital diet. Five patients received the amino acid\u2013glucose solution, while 10 received the glucose solution without amino acids. There was more improvement in nitrogen balance in the treated group than the control group. However, amino acid therapy was no more beneficial than control therapy in improving creatinine\u2013height index, arm muscle area, arm fat area, and plasma levels of retinol binding proteins, prealbumin and pyridoxal\u20135\u2032\u2013phosphate. Clinical and biochemical markers of liver disease improved in both groups. This improvement in composite clinical index was more rapid in the treated than in the control group, but this early advantage was no longer apparent at the end of one month. Hepatocellular necrosis, inflammation and fat improved in the entire group. Amino acid treatment resulted in a greater resolution of fatty infiltration, but did not otherwise affect hepatic histology. Hepatocellular necrosis and inflammation in both the initial and final liver biopsies were highly correlated with nitrogen balance on admission. Initial clinical index correlated with the quantity of ethanol consumption prior to admission but not with liver injury on biopsy. However, by the end of the study, clinical index correlated with hepatocellular necrosis and inflammation. It is concluded that the clinical syndrome of alcoholic hepatitis is heavily influenced initially by metabolic consequences of alcohol consumption and that it is the resolution of this alcohol effect that is most influenced by parenteral amino acid supplementation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840050114","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T18:03:13Z","timestamp":1172944993000},"page":"57-63","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":78,"title":["Effect of Parenteral Amino Acid Supplementation in Alcoholic Hepatitis"],"prefix":"10.1097","volume":"5","author":[{"given":"Anna Mae","family":"Diehl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K.","family":"Boitnott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin H.","family":"Herlong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Van Duyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Mezey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050114-BIB1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1749-6632.1975.tb19146.x","volume":"252","author":"Lelbach","year":"1975","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840050114-BIB2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/ajcp\/63.3.318","volume":"63","author":"Peters","year":"1975","journal-title":"Am J Clin Pathol"},{"key":"10.1002\/hep.1840050114-BIB3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0016-5085(80)90869-0","volume":"78","author":"Falchuk","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050114-BIB4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/hep.1840030106","volume":"3","author":"Mezey","year":"1983","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840050114-BIB5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archinte.1975.00330080055008","volume":"135","author":"Patek","year":"1975","journal-title":"Arch Intern Med"},{"key":"10.1002\/hep.1840050114-BIB6","doi-asserted-by":"crossref","first-page":"814","DOI":"10.7326\/0003-4819-60-5-814","volume":"60","author":"Ereneglou","year":"1964","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840050114-BIB7","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(80)92338-7","volume":"2","author":"Nasrallah","year":"1980","journal-title":"Lancet"},{"key":"10.1002\/hep.1840050114-BIB8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","volume":"2","author":"Mancini","year":"1965","journal-title":"Immunochemistry"},{"key":"10.1002\/hep.1840050114-BIB9","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0016-5085(84)80110-9","volume":"86","author":"Diehl","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050114-BIB10","first-page":"153","volume-title":"Manual of nutritional therapeutics","author":"Alpers","year":"1983","unstructured":", , et al. 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Statistical methods, 6th ed. Ames, Iowa: Iowa State University Press, 1967."},{"key":"10.1002\/hep.1840050114-BIB18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/ajcn\/38.3.469","volume":"38","author":"Bunout","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/hep.1840050114-BIB19","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/ajcn\/38.6.849","volume":"38","author":"Mills","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/hep.1840050114-BIB20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/ajcn\/33.3.631","volume":"33","author":"Pitchumone","year":"1980","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/hep.1840050114-BIB21","first-page":"17","volume-title":"Alcohol and the Gastrointestinal Tract Paris","volume":"95","author":"Pequinot","year":"1980","unstructured":". Compared toxicity of ethanol on various organs. In: , eds. 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