{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:21:22Z","timestamp":1762078882966,"version":"3.30.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11200,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:italic toggle=\"yes\">In vivo<\/jats:italic> insulin sensitivity and adipocyte insulin binding and action were assessed in 16 patients with histologically proven hepatic cirrhosis and 11 age\u2013, weight\u2013 and sex\u2013matched normal control subjects. The cirrhotic group displayed impaired oral glucose tolerance, despite an exaggerated serum immunoreactive insulin response, and <jats:italic toggle=\"yes\">in vivo<\/jats:italic> insulin resistance as assessed both by the euglycemic hyperinsulinemic clamp and the glucose\u2013insulin infusion techniques. Adipocytes of the cirrhotic patients bound significantly less insulin than those of the control subjects (2.21 \u00b1 0.12% vs. 2.64 \u00b1 0.13%; p &lt; 0.05). Although the adipocytes from the cirrhotic patients were less sensitive to insulin stimulation <jats:italic toggle=\"yes\">in vitro<\/jats:italic> (half\u2013maximal stimulation at 60.0 \u00b1 8.0 vs. 21.8 \u00b1 3.3 pM; p &lt; 0.001), they exhibited higher maximum rates of lipogenesis. Comparison of the responses of the alcoholic, primary biliary cirrhosis and cryptogenic subgroups suggested pronounced differences in the maximum rates of lipogenesis. There were significant negative correlations between specific binding to adipocytes and both fasting serum immunoreactive insulin and <jats:italic toggle=\"yes\">in vivo<\/jats:italic> insulin resistance as assessed by glucose\u2013insulin infusion. Monocyte insulin binding was normal in the cirrhotic group and did not correlate with <jats:italic toggle=\"yes\">in vivo<\/jats:italic> insulin resistance. It is concluded that both binding and postbinding defects in insulin target organ cells contribute to the marked <jats:italic toggle=\"yes\">in vivo<\/jats:italic> insulin resistance of hepatic cirrhosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840050115","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T18:03:13Z","timestamp":1172944993000},"page":"64-71","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":64,"title":["Insulin Action in Cirrhosis"],"prefix":"10.1097","volume":"5","author":[{"given":"R.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Heine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. F.W.","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. G.M.M.","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050115-BIB1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1001\/archinte.1970.00310100054004","volume":"126","author":"Collins","year":"1970","journal-title":"Arch Intern Med"},{"key":"10.1002\/hep.1840050115-BIB2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1055\/s-2007-1018914","volume":"14","author":"Johnston","year":"1982","journal-title":"Horm Metabolic Res"},{"key":"10.1002\/hep.1840050115-BIB3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0026-0495(82)90103-2","volume":"31","author":"Riggio","year":"1982","journal-title":"Metabolism"},{"key":"10.1002\/hep.1840050115-BIB4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/cs0590191","volume":"59","author":"Leatherdale","year":"1980","journal-title":"Clin Sci"},{"key":"10.1002\/hep.1840050115-BIB5","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/BF00253183","volume":"19","author":"Jorgensen","year":"1980","journal-title":"Diabetologia"},{"key":"10.1002\/hep.1840050115-BIB6","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/0026-0495(81)90074-3","volume":"30","author":"Abumrad","year":"1981","journal-title":"Metabolism"},{"key":"10.1002\/hep.1840050115-BIB7","first-page":"e214","volume":"327","author":"DeFronzo","year":"1979","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840050115-BIB8","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/0026-0495(78)90091-4","volume":"27","author":"Harano","year":"1978","journal-title":"Metabolism"},{"key":"10.1002\/hep.1840050115-BIB9","first-page":"51","volume":"21","author":"Boyum","year":"1968","journal-title":"Scand J Clin Invest"},{"key":"10.1002\/hep.1840050115-BIB10","first-page":"301","volume-title":"Methods in receptor research part I","author":"DeMeyts","year":"1976","unstructured":"Insulin and growth hormone receptors in human cultured lymphocytes and peripheral blood monocytes. In: ed. Methods in receptor research part I. New York: Marcel Dekker, 1976: 301\u2013383."},{"key":"10.1002\/hep.1840050115-BIB11","first-page":"636","volume":"20","author":"Pedersen","year":"1981","journal-title":"Diabetologia"},{"key":"10.1002\/hep.1840050115-BIB12","doi-asserted-by":"crossref","first-page":"7857","DOI":"10.1016\/S0021-9258(17)34450-2","volume":"253","author":"Gliemann","year":"1978","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840050115-BIB13","first-page":"e158","volume":"243","author":"Pedersen","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840050115-BIB14","first-page":"2575","volume":"235","author":"Dole","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840050115-BIB15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bj0880137","volume":"88","author":"Hales","year":"1968","journal-title":"Biochem J"},{"key":"10.1002\/hep.1840050115-BIB16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/BF01222104","volume":"11","author":"Heding","year":"1975","journal-title":"Diabetologia"},{"key":"10.1002\/hep.1840050115-BIB17","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/clinchem\/24.10.1724","volume":"24","author":"Lloyd","year":"1978","journal-title":"Clin Chem"},{"key":"10.1002\/hep.1840050115-BIB18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0140-6736(77)91652-X","volume":"1","author":"Johnston","year":"1977","journal-title":"Lancet"},{"key":"10.1002\/hep.1840050115-BIB19","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0140-6736(67)90334-0","volume":"2","author":"Megyesi","year":"1967","journal-title":"Lancet"},{"key":"10.1002\/hep.1840050115-BIB20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2337\/diab.27.1.S201","volume":"27","author":"Johnston","year":"1978","journal-title":"Diabetes"},{"year":"1980","author":"WHO","key":"10.1002\/hep.1840050115-BIB21","unstructured":"WHO. Expert Committee on Diabetes Mellitus\u2014Second Report, World Health Organization Technical Report Series 646, 1980."},{"key":"10.1002\/hep.1840050115-BIB22","first-page":"533","volume-title":"Gluconeogenesis: its regulation in mammalian species","author":"Owen","year":"1976","unstructured":", , et al. Gluconeogenesis in normal, cirrhotic and diabetic humans. In: , eds. Gluconeogenesis: its regulation in mammalian species. New York: John Wiley and Sons, 1976: p. 533."},{"key":"10.1002\/hep.1840050115-BIB23","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1210\/jcem-46-5-778","volume":"46","author":"Perez","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/hep.1840050115-BIB24","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0026-0495(82)90011-7","volume":"31","author":"Harewood","year":"1982","journal-title":"Metabolism"},{"key":"10.1002\/hep.1840050115-BIB25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1055\/s-2007-999204","volume":"12","author":"Greco","year":"1980","journal-title":"Horm Metabolic Res"},{"key":"10.1002\/hep.1840050115-BIB26","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0016-5085(82)80127-3","volume":"83","author":"Blei","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050115-BIB27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2957\/kanzo.22.173","volume":"22","author":"Kanatsuna","year":"1981","journal-title":"Acta Hepatol Jap"},{"key":"10.1002\/hep.1840050115-BIB28","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1172\/JCI108384","volume":"57","author":"Olefsky","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840050115-BIB29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/cs0670139","volume":"67","author":"Taylor","year":"1984","journal-title":"Clin Sci"},{"key":"10.1002\/hep.1840050115-BIB30","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2337\/diab.31.8.706","volume":"31","author":"Pedersen","year":"1982","journal-title":"Diabetes"},{"key":"10.1002\/hep.1840050115-BIB31","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/S0026-0495(78)80007-9","volume":"27","author":"Kahn","year":"1978","journal-title":"Metabolism"},{"key":"10.1002\/hep.1840050115-BIB32","first-page":"825","volume-title":"Hepatology","author":"Vierling","year":"1982","unstructured":"Primary biliary cirrhosis. In: , eds. Hepatology. Philadelphia: W. B. Saunders, 1982: 825\u2013862."}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840050115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198501000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:09:53Z","timestamp":1733051393000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198501000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840050115","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}