{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:54:32Z","timestamp":1791053672202,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11141,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,3]]},"abstract":"\n \n Blood alcohol levels (BAL) were maintained at high levels (overall mean \u00b1 S.D. achieved in 14 alcoholic rats was 216.0 \u00b1 120.1 mg%) in male Wistar rats for 15 to 85 days by continuous intragastric infusion of ethanol and nutritionally defined low fat liquid diet. The ethanol intake was progressively increased from 32% of total calories up to 41.4% in order to maintain high BAL. Pair\u2013fed animals received isocaloric glucose solution and the liquid diet. Despite the low level of dietary fat (4.9% of total calories), histopathological evaluation of the liver revealed severe and progressive fatty infiltration in the alcoholic rats. In addition, following 30 days of intoxication, one third of the animals showed focal necrosis with mononuclear cell infiltration in centrilobular areas of the livers. This was correlated with the markedly elevated levels of SGOT and SGPT in these animals. Pair\u2013fed controls showed no abnormality in the morphology of liver or blood chemistry. Chemical quantitation of liver triglycerides confirmed the histological observation, with triglyceride levels of 61.51 \u00b1 16.45 and 89.61 \u00b1 5.94 mg per gm at 30 and 85 days, respectively. Most importantly, the degree of steatosis was tightly and significantly correlated with the mean BAL achieved (r = 0.80, p < 0.001). These data represent the first confirmation of the hypothesis that continuously high BAL correlate with the severity of alcohol\u2013induced liver pathology.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840050212","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:59:21Z","timestamp":1172944761000},"page":"224-232","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":209,"title":["Severe and Progressive Steatosis and Focal Necrosis in Rat Liver Induced by Continuous Intragastric Infusion of Ethanol and Low Fat Diet"],"prefix":"10.1097","volume":"5","author":[{"given":"Hidekazu","family":"Tsukamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Benson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda G.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.","family":"Larkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Largman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050212-BIB1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1056\/NEJM197401172900303","volume":"290","author":"Rubin","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840050212-BIB2","first-page":"359","volume-title":"Animal models in alcohol research","author":"Salaspuro","year":"1980","unstructured":". Comparison of the detrimental effects of chronic alcohol intake in humans and animals. In: , eds. Animal models in alcohol research. New York: Academic Press, 1980: 359\u2013376."},{"key":"10.1002\/hep.1840050212-BIB3","first-page":"1232","volume":"35","author":"Lieber","year":"1976","journal-title":"Fed Proc"},{"key":"10.1002\/hep.1840050212-BIB4","first-page":"615","volume":"22","author":"Lieber","year":"1970","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840050212-BIB5","first-page":"445","volume-title":"Animal models in alcohol research","author":"Lindros","year":"1980","unstructured":", , et al. An improved animal model for production of alcohol liver damage using a nutritionally adequate liquid diet containing ethanol and 4-methylpyrazole. In: , eds. Animal models in alcohol research. New York: Academic Press, 1980: 445\u2013452."},{"key":"10.1002\/hep.1840050212-BIB6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0031-6989(74)80039-1","volume":"6","author":"Smith","year":"1974","journal-title":"Pharmac Res Commun"},{"key":"10.1002\/hep.1840050212-BIB7","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/0024-3205(80)90382-3","volume":"27","author":"Derr","year":"1980","journal-title":"Life Sci"},{"key":"10.1002\/hep.1840050212-BIB8","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.564551","volume":"199","author":"Erickson","year":"1978","journal-title":"Science"},{"key":"10.1002\/hep.1840050212-BIB9","author":"Tsukamoto","year":"1985","unstructured":", , et al. Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats. Alcoholism Clin Exp Res 1985 (in press)."},{"key":"10.1002\/hep.1840050212-BIB10","first-page":"r595","volume":"247","author":"Tsukamoto","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840050212-BIB11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/BF02533593","volume":"13","author":"Thompson","year":"1978","journal-title":"Lipids"},{"key":"10.1002\/hep.1840050212-BIB12","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/BF02533548","volume":"15","author":"Goheen","year":"1980","journal-title":"Lipids"},{"key":"10.1002\/hep.1840050212-BIB13","first-page":"289","volume":"76","author":"Lieber","year":"1963","journal-title":"Trans Assoc Am Physicians"},{"key":"10.1002\/hep.1840050212-BIB14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00426650","volume":"68","author":"Miller","year":"1980","journal-title":"Psychopharmacology"},{"key":"10.1002\/hep.1840050212-BIB15","first-page":"695","volume":"98","author":"Popper","year":"1980","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840050212-BIB16","first-page":"660","volume":"77","author":"Takada","year":"1982","journal-title":"Am J Gastroenterol"},{"key":"10.1002\/hep.1840050212-BIB17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/ajcn\/23.4.474","volume":"23","author":"Lieber","year":"1970","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/hep.1840050212-BIB18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF02534703","volume":"18","author":"Goheen","year":"1983","journal-title":"Lipids"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840050212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198503000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:03:27Z","timestamp":1733051007000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198503000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840050212","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}