{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:05:34Z","timestamp":1786118734836,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11141,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Serum \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2013microglobulin (\u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u03bc) was determined in 44 patients with primary biliary cirrhosis (PBC) and in 63 patients with other liver disorders. \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u03bc levels were elevated in PBC when compared with chronic persistent hepatitis, primary sclerosing cholangitis and noncirrhotic alcohol liver disease, but not in comparison with chronic active hepatitis and alcoholic liver cirrhosis. With the exception of chronic persistent hepatitis, all liver disorders had significantly increased serum concentrations of \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u03bc when compared with controls. A significant correlation between \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u03bc and erythrocyte sedimentation rate (p &lt; 0.001) and \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u03bc and serum IgG (p &lt; 0.05) was found in PBC. No significant difference in \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u03bc levels was noted when PBC patients with early and late histopathological changes were compared. D\u2013penicillamine treatment significantly (p &lt; 0.01) but transiently reduced \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u03bc levels in PBC; this may reflect the presumed immunosuppressive action of this drug.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.1840050222","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T12:59:21Z","timestamp":1172926761000},"page":"282-285","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Serum \u03b22\u2013Microglobulin Levels in Primary Biliary Cirrhosis"],"prefix":"10.1097","volume":"5","author":[{"given":"Anders","family":"Nyberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"L\u00f6\u00f6f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"H\u00e4llgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050222-BIB1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1136\/gut.18.6.472","volume":"18","author":"Sanchez-Tapias","year":"1977","journal-title":"Gut"},{"key":"10.1002\/hep.1840050222-BIB2","first-page":"269","volume-title":"Frontiers in liver disease","author":"Thomas","year":"1981","unstructured":". Immunologic aspects of the pathogenesis and treatment of primary biliary cirrhosis. In: , eds. Frontiers in liver disease. New York: Thieme Stratton, 1981: 269\u2013282."},{"key":"10.1002\/hep.1840050222-BIB3","first-page":"131","volume-title":"Recent advances in hepatology. London","author":"Anthony","year":"1983","unstructured":"Primary biliary cirrhosis: potential pathogenic mechanisms and the effects of therapies on the disease process. In: , eds. Recent advances in hepatology. 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