{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:15:16Z","timestamp":1775686516656,"version":"3.50.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11141,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>We examined \u03b2<jats:sub>2<\/jats:sub>\u2013microglobulin (B2MG) excretion, an index of tubular function, in patients with hepatorenal syndrome, in whom tubular function is generally regarded as normal. Urine B2MG was significantly higher in these patients than in control patients with normal serum creatinine concentration. Patients with high urine B2MG concentration had markedly higher serum bilirubin than did patients with normal values (31 \u00b1 3 vs. 10 \u00b1 8 mg%, p &lt; 0.001), whereas prothrombin activity, serum albumin and serum B2MG concentration were similar. A \u201cthreshold\u201d serum bilirubin concentration of about 23 mg% differentiated patients with normal and high urine B2MG values. Renal morphology at autopsy was unremarkable in both groups. Tubular dysfunction, manifested by increased urinary excretion of B2MG, occurs in patients with hepatorenal syndrome and deep jaundice. This measurement cannot, therefore, be used to make a diagnosis of acute tubular injury, as due to aminoglycosides, in such patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840050229","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:59:21Z","timestamp":1172944761000},"page":"321-326","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Tubular Dysfunction in the Deeply Jaundiced Patient With Hepatorenal Syndrome"],"prefix":"10.1097","volume":"5","author":[{"given":"William G.","family":"Rector","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary C.","family":"Kanel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Rakela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Telfer B.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050229-BIB1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0016-5085(19)33116-6","volume":"65","author":"Conn","year":"1973","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050229-BIB2","first-page":"129","volume-title":"Diseases of the liver and biliary system","author":"Sherlock","year":"1981","unstructured":"Diseases of the liver and biliary system. Oxford: Blackwell Scientific Publications, 1981: 129."},{"key":"10.1002\/hep.1840050229-BIB3","first-page":"1644","volume-title":"Textbook of medicine","author":"Jeffries","year":"1979","unstructured":"Mechanisms of hepatic disease. In: , eds. Textbook of medicine. Philadelphia: W. B. Saunders, 1979: 1644."},{"key":"10.1002\/hep.1840050229-BIB4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7326\/0003-4819-89-1-47","volume":"89","author":"Miller","year":"1978","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840050229-BIB5","first-page":"307","volume-title":"The liver and its diseases","author":"Reynolds","year":"1974","unstructured":"The hepatorenal syndrome. In: , eds. The liver and its diseases. New York: Intercontinental Medical Book Corp., 1974: 307\u2013313."},{"key":"10.1002\/hep.1840050229-BIB6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jcp.31.2.101","volume":"31","author":"Wilkinson","year":"1978","journal-title":"J Clin Pathol"},{"key":"10.1002\/hep.1840050229-BIB7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/gut.22.7.585","volume":"22","author":"Ring","year":"1981","journal-title":"Gut"},{"key":"10.1002\/hep.1840050229-BIB8","first-page":"87","volume-title":"The kidney in liver disease","author":"Popper","year":"1983","unstructured":"Hepatorenal syndrome. In: ed. The kidney in liver disease. New York: Elsevier, 1983: 87\u2013106."},{"key":"10.1002\/hep.1840050229-BIB9","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1172\/JCI106083","volume":"48","author":"Peterson","year":"1969","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840050229-BIB10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000182026","volume":"27","author":"Hall","year":"1981","journal-title":"Nephron"},{"key":"10.1002\/hep.1840050229-BIB11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0016-5085(82)90129-9","volume":"82","author":"Cabrera","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050229-BIB12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/00365517209081057","volume":"29","author":"Evrin","year":"1972","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1002\/hep.1840050229-BIB13","first-page":"781","volume-title":"Pathology of the kidney","author":"Heptinstall","year":"1974","unstructured":"Acute renal failure. In: ed. Pathology of the kidney. Boston: Little, Brown and Co., 1974: 781\u2013820."},{"key":"10.1002\/hep.1840050229-BIB14","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hep.1840040212","volume":"4","author":"Kanel","year":"1984","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840050229-BIB15","volume-title":"Statistics in medicine","author":"Colton","year":"1974","unstructured":"Statistics in medicine. 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