{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:32:07Z","timestamp":1768347127401,"version":"3.49.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11080,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Pathological lesions of the liver were studied in 14 cases of hairy cell leukemia, a rare hematologic neoplasm involving numerous organs. Tumor infiltration of hepatic parenchyma was observed in all cases. Tumor cells were easily recognized by their cytological features, namely their \u201chalo\u201d appearance consisting of a clear rim of abundant cytoplasm surrounding uniform round or slightly indented nuclei. Portal infiltration was observed in all cases, associated with sinusoidal infiltration in 12 cases. A peculiar change of the sinusoids, i.e., the angiomatous lesions, was noted in 9 of 14 patients. Angiomatous lesions consisted of intralobular cavities without zonal predominance which were lined by tumor cells which replaced the normal sinusoidal wall and were filled with red blood cells and tumor cells. This pattern of involvement is different from hepatic localization of other blood malignancies and is highly suggestive of hairy, cell leukemia. It might reflect the unique phenotype of the tumor cells, which express lymphocytic and monocytic features. The angiomatous lesion strongly mimics peliosis hepatis and could be, as well as in peliosis, the consequence of modification of the sinusoidal barrier. In hairy cell leukemia, sinusoidal wall abnormalities might be secondary to infiltration of the sinusoids by tumor cells.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840050326","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:24:01Z","timestamp":1172949841000},"page":"496-500","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":38,"title":["Histopathological Lesions of the Liver in Hairy Cell Leukemia: A Report of 14 Cases"],"prefix":"10.1097","volume":"5","author":[{"given":"Marie-Laurence","family":"Roquet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie-Serge","family":"Zafrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Farcet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvon","family":"Pinaudeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050326-BIB1","first-page":"609","volume":"13","author":"Flandrin","year":"1973","journal-title":"Nouv Rev Fr Hematol"},{"key":"10.1002\/hep.1840050326-BIB2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/1097-0142(197405)33:5<1399::AID-CNCR2820330526>3.0.CO;2-E","volume":"33","author":"Burke","year":"1974","journal-title":"Cancer"},{"key":"10.1002\/hep.1840050326-BIB3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0002-9343(74)90776-1","volume":"57","author":"Katayama","year":"1974","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840050326-BIB4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.7326\/0003-4819-89-5-677","volume":"89","author":"Golomb","year":"1978","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840050326-BIB5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1182\/blood.V53.3.412.412","volume":"53","author":"Bouroncle","year":"1979","journal-title":"Blood"},{"key":"10.1002\/hep.1840050326-BIB6","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.1073\/pnas.80.14.4522","volume":"80","author":"Korsmeyer","year":"1983","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840050326-BIB7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1182\/blood.V51.1.61.61","volume":"51","author":"Cawley","year":"1978","journal-title":"Blood"},{"key":"10.1002\/hep.1840050326-BIB8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/ajcp\/80.4.421","volume":"80","author":"Hsu","year":"1983","journal-title":"Am J Clin Pathol"},{"key":"10.1002\/hep.1840050326-BIB9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1182\/blood.V52.3.537.537","volume":"52","author":"Reyes","year":"1978","journal-title":"Blood"},{"key":"10.1002\/hep.1840050326-BIB10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/ajcp\/67.5.415","volume":"67","author":"Nanba","year":"1977","journal-title":"Am J Clin Pathol"},{"key":"10.1002\/hep.1840050326-BIB11","first-page":"926","volume-title":"Liver and biliary disease. Pathophysiology. Diagnosis. Management","author":"Wright","year":"1979","unstructured":"Involvement of the liver by lymphoreticular disease. In: , , et al., eds. Liver and biliary disease. Pathophysiology. Diagnosis. Management. London: W. B. Saunders Co., 1979: 926\u2013940."},{"key":"10.1002\/hep.1840050326-BIB12","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/1097-0142(19830415)51:8<1497::AID-CNCR2820510824>3.0.CO;2-0","volume":"51","author":"Yam","year":"1983","journal-title":"Cancer"},{"key":"10.1002\/hep.1840050326-BIB13","first-page":"191","volume-title":"Kupffer cells and other liver sinusoidal cells","author":"Delsol","year":"1977","unstructured":", , et al. Hairy cell leukemia. A disease of the mononuclear phagocytes? In: , eds. Kupffer cells and other liver sinusoidal cells. Amsterdam: Elsevier-North-Holland Biomedical Press, 1977: 191\u2013200."},{"key":"10.1002\/hep.1840050326-BIB14","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/ajcp\/70.6.876","volume":"70","author":"Burke","year":"1978","journal-title":"Am J Clin Pathol"},{"key":"10.1002\/hep.1840050326-BIB15","first-page":"683","volume-title":"Progress in liver diseases","author":"Kim","year":"1976","unstructured":", . Pathology of malignant lymphomas in the liver: application in staging. In: , eds. Progress in liver diseases, Vol V. 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