{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:07:59Z","timestamp":1758395279748,"version":"3.30.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11019,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The effect of acute metabolic or respiratory acid\u2013base disturbances on biliary bicarbonate secretion was examined in bile fistula rats. Animals were infused with ursodeoxycholate at a rate that stimulates bicarbonate secretion (1 \u03bcmole \u00b7 min<jats:sup>-1<\/jats:sup> \u00b7 100 gm<jats:sup>-1<\/jats:sup>), in control conditions and during acute acid\u2013base disturbances. Metabolic acidosis or alkalosis were induced by HCl or NaHCO<jats:sub>3<\/jats:sub> infusions, and respiratory acidosis or alkalosis were created respectively by adding CO<jats:sub>2<\/jats:sub> to the inspired gas or by hyperventilation in artificially ventilated animals. Biliary bicarbonate concentration was always higher than plasma bicarbonate concentration. During metabolic disturbances, changing the plasma bicarbonate concentration from 9.2 to 30.2 m<jats:italic toggle=\"yes\">M<\/jats:italic> stimulated biliary bicarbonate secretion by 113%. During respiratory disturbances, changing the plasma PCO<jats:sub>2<\/jats:sub> from 25.5 to 59.8 mm Hg also increased biliary bicarbonate secretion by 89%. Biliary bicarbonate output was thus independent of plasma pH. When all animals were considered, bile flow was positively correlated with biliary bicarbonate concentration (r = 0.71, p &lt; 0.001). Acetazolamide significantly decreased ursodeoxycholate\u2013induced bile flow and bicarbonate secretion by 20 and 22%, respectively. These results support the hypothesis that there is a relationship between ursodeoxycholate\u2013induced bicarbonate secretion and bile flow. They are also consistent with the view that ursodeoxycholate\u2013stimulated biliary bicarbonate secretion in the rat is strongly affected by plasma bicarbonate and PCO<jats:sub>2<\/jats:sub>, but not by plasma pH, and involves carbonic anhydrase.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840050412","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:21:40Z","timestamp":1172949700000},"page":"594-599","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Systemic Ph, Pco2 and Bicarbonate Concentration on Biliary Bicarbonate Secretion in the Rat"],"prefix":"10.1097","volume":"5","author":[{"given":"Mich\u00e8le","family":"Corbic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micheline","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghislaine","family":"De Cou\u00ebt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Erlinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050412-BIB1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.ph.39.030177.001543","volume":"39","author":"Forker","year":"1977","journal-title":"Ann Rev Physiol"},{"key":"10.1002\/hep.1840050412-BIB2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1152\/physrev.1980.60.2.303","volume":"60","author":"Boyer","year":"1980","journal-title":"Physiol Rev"},{"key":"10.1002\/hep.1840050412-BIB3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/hep.1840010413","volume":"1","author":"Erlinger","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840050412-BIB4","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0016-5085(83)80091-2","volume":"85","author":"Scharschmidt","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050412-BIB5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1172\/JCI110642","volume":"70","author":"Van Dyke","year":"1982","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840050412-BIB6","first-page":"g628","volume":"242","author":"Scharschmidt","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840050412-BIB7","first-page":"g116","volume":"244","author":"Anwer","year":"1983","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840050412-BIB8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3181\/00379727-176-41844","volume":"176","author":"Anwer","year":"1984","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1002\/hep.1840050412-BIB9","first-page":"284","volume":"225","author":"Anwer","year":"1984","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/hep.1840050412-BIB10","first-page":"e158","volume":"235","author":"Hardison","year":"1978","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840050412-BIB11","first-page":"190","volume":"206","author":"Barnhart","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/hep.1840050412-BIB12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0016-5085(80)90078-5","volume":"79","author":"Dumont","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050412-BIB13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1172\/JCI110658","volume":"70","author":"Sasaki","year":"1982","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840050412-BIB14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1748-1716.1980.tb06585.x","volume":"109","author":"F\u00e6der","year":"1980","journal-title":"Acta Physiol Scand"},{"key":"10.1002\/hep.1840050412-BIB15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2362.1983.tb00087.x","volume":"13","author":"Mathisen","year":"1983","journal-title":"Eur J Clin Invest"},{"key":"10.1002\/hep.1840050412-BIB16","first-page":"g230","volume":"245","author":"Charney","year":"1983","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840050412-BIB17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/ajplegacy.1970.219.3.809","volume":"219","author":"Berthelot","year":"1970","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840050412-BIB18","volume-title":"Statistical Methods","author":"Snedecor","year":"1967","unstructured":". 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