{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:46:59Z","timestamp":1774676819960,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10957,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>An IgM\u2013specific anti\u2013[anti\u2013HBs] antibody was detected by radioimmunoassay using anti\u2013IgM\u2013coated beads and <jats:sup>125<\/jats:sup>I\u2013labeled anti\u2013HBs. This antiidiotype was found only in the sera of hepatitis B virus\u2013infected patients, both acute and chronic. However, not all HBsAg\u2013positive patients exhibited this reaction, and activity was correlated with the presence of HBeAg. Approximately 93% of sera that contained antiidiotype activity also contained HBeAg. Conversely, 70% of the sera positive for HBeAg reacted in the IgM assay. No correlation was observed between the presence of antiidiotype and rheumatoid factor or elevated SGPT levels.<\/jats:p>\n            <jats:p>Two approaches were used to determine whether the reactive moiety was an IgM anti\u2013[anti\u2013HBs] as postulated or an IgM anti\u2013HBs\/HBsAg complex. It was shown that chicken anti\u2013HBs sera, which does not share the common idiotype of human and other mammalian anti\u2013HBs, did not block a positive reaction in this radioimmunoassay even though it specifically bound HBsAg. It was also demonstrated that treatment with polyethylene gylcol, which will precipitate IgM anti\u2013HBs\/HBsAg activity, did not precipitate the reactive moiety in 6 of 7 sera tested, lending further evidence to the existence of an IgM antiidiotype in these patients.<\/jats:p>\n            <jats:p>It is suggested that this antiidiotype directed against anti\u2013HBs may be involved in a defective feedback mechanism resulting in the suppression of production of anti\u2013HBs and maintenance of the carrier state.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840050509","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:13:55Z","timestamp":1172949235000},"page":"758-762","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Detection of An Igm Antiidiotype Directed Against Anti\u2013Hbs in Hepatitis B Patients"],"prefix":"10.1097","volume":"5","author":[{"given":"Catherine L.","family":"Troisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blaine F.","family":"Hollinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050509-BIB1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1126\/science.165.3890.304","volume":"165","author":"Shulman","year":"1969","journal-title":"Science"},{"key":"10.1002\/hep.1840050509-BIB2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/infdis\/120.3.383","volume":"120","author":"Purcell","year":"1969","journal-title":"J Infect 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Response to hepatitis B vaccine in a young adult population. In: , eds. Viral hepatitis, 1981 International Symposium Philadelphia: Franklin Institute Press, 1981: 451\u2013466."},{"key":"10.1002\/hep.1840050509-BIB21","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/eji.1830130310","volume":"13","author":"Kennedy","year":"1983","journal-title":"Eur J Immunol"},{"key":"10.1002\/hep.1840050509-BIB22","first-page":"899","volume-title":"Manual of clinical microbiology","author":"Hollinger","year":"1980","unstructured":". Hepatitis viruses. In: ed. Manual of clinical microbiology, 3rd ed. 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