{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:05:18Z","timestamp":1786118718464,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10957,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Spleen cells obtained from C57BL\/6 (B6) mice with an experimental autoimmune hepatitis were transferred to normal C57BL\/6 recipient mice. Most prominent liver damages occurred in the recipient mice injected with sensitized nylon wool column\u2013adherent spleen cells from the donor mice. Production of such liver damage was blocked by treatment of the sensitized adherent spleen cells with anti\u2013Thy 1,2 monoclonal antibody and complement before injection. Based on these\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      results, a microcytotoxicity assay was performed using isolated C57BL\/6 hepatocytes as target cells and sensitized spleen cells obtained from hepatitis donor mice as effector cells. The fraction of sensitized nylon wool\u2013adherent spleen cells demonstrated a high cytotoxic activity against isolated syngeneic hepatocytes, although the other fractions and spleen cells of control animals showed no such effect. The cytotoxic activity of sensitized\u2013adherent spleen cells against target hepatocytes was significantly reduced after treatment with anti\u2013Thy 1,2 antibody and complement, but it increased after depletion of B cells and Fc receptor\u2013bearing T\u2013cells. Although these sensitized nylon wool\u2013adherent spleen cells showed high cytotoxic activities against syngeneic hepatocytes, their cytotoxicity against allogeneic hepatocytes was lower. They exerted no cytotoxic activity against syngeneic renal glomerular cells and EL\u20134 thymoma cells. These results suggest that sensitized T\u2013cells in the nylon wool column\u2013adherent fraction play the role of cytotoxic killer cells against target liver cells\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.1840050511","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T14:13:55Z","timestamp":1172931235000},"page":"770-777","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Cell\u2013Mediated Cytotoxicity of Sensitized Spleen Cells Against Target Liver Cells\u2014 In Vivo And In Vitro Study With A Mouse Model of Experimental Autoimmune Hepatitis"],"prefix":"10.1097","volume":"5","author":[{"given":"Teruo","family":"Mori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Iesato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Wakashin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Wakashin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050511-BIB1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/gut.17.9.714","volume":"17","author":"Cochrane","year":"1976","journal-title":"Gut"},{"key":"10.1002\/hep.1840050511-BIB2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(76)91472-0","volume":"28","author":"Cochrane","year":"1976","journal-title":"Lancet"},{"key":"10.1002\/hep.1840050511-BIB3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0016-5085(19)32139-0","volume":"73","author":"Kawanishi","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050511-BIB4","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/252721a0","volume":"252","author":"Thomson","year":"1974","journal-title":"Nature"},{"key":"10.1002\/hep.1840050511-BIB5","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1172\/JCI108021","volume":"55","author":"Wand","year":"1975","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840050511-BIB6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0008-8749(78)90249-6","volume":"36","author":"Kakumu","year":"1978","journal-title":"Cell Immunol"},{"key":"10.1002\/hep.1840050511-BIB7","first-page":"85","volume":"57","author":"Mori","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840050511-BIB8","first-page":"82","volume":"10","author":"Meyer zum B\u00fcschenfelde","year":"1972","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840050511-BIB9","first-page":"381","volume":"27","author":"McFarlane","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840050511-BIB10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/eji.1830031011","volume":"3","author":"Julius","year":"1973","journal-title":"Eur. 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